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Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactones

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Resumo:In this work, core/shell magnetic nanoparticles of manganese ferrite/gold were prepared and characterized. In order to develop applications in combined cancer therapy, the prepared nanoparticles were covered with a lipid bilayer (forming magnetoliposomes), these systems being able to transport drugs. TEM and DLS measurements indicated that these systems exhibit sizes around 120 nm. Two new potential antitumor tricyclic lactones were successfully encapsulated in these nanocarriers. The heating capabilities of the developed nanosystems were evaluated upon excitation with a light source. These multifunctional nanosystems have shown promising results for application combined cancer therapy (chemo/phototherapy).
Autores principais:Rio, Irina S. R.
Outros Autores:Rodrigues, Juliana M.; Rodrigues, Ana Rita Oliveira; Coutinho, Paulo J. G.; Castanheira, Elisabete M. S.; Queiroz, Maria João R. P.
Assunto:Magnetic/plasmonic nanoparticles Magnetoliposomes Drug delivery Antitumor drugs Cancer therapy
Ano:2019
País:Portugal
Tipo de documento:outro
Tipo de acesso:acesso aberto
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho

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