Publicação
Cell secretome: basic insights and therapeutic opportunities for CNS disorders
| Resumo: | Transplantation of stem cells, in particular mesenchymal stem cells (MSCs), stands as a promising therapy for trauma, stroke or neurodegenerative conditions such as spinal cord or traumatic brain injuries (SCI or TBI), ischemic stroke (IS), or Parkinson’s disease (PD). Over the last few years, cell transplantation-based approaches have started to focus on the use of cell byproducts, with a strong emphasis on cell secretome. Having this in mind, the present review discusses the current state of the art of secretome-based therapy applications in different central nervous system (CNS) pathologies. For this purpose, the following topics are discussed: (1) What are the main cell secretome sources, composition, and associated collection techniques; (2) Possible differences of the therapeutic potential of the protein and vesicular fraction of the secretome; and (3) Impact of the cell secretome on CNS-related problems such as SCI, TBI, IS, and PD. With this, we aim to clarify some of the main questions that currently exist in the field of secretome-based therapies and consequently gain new knowledge that may help in the clinical application of secretome in CNS disorders. |
|---|---|
| Autores principais: | Pinho, Andreia G. |
| Outros Autores: | Cibrão, Jorge R.; Silva, Nuno A.; Monteiro, Susana; Salgado, A. J. |
| Assunto: | central nervous system ischemic stroke mesenchymal stem cells Parkinson’s disease regeneration spinal cord injury secretome traumatic brain injury |
| Ano: | 2020 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1866875970206564352 |
|---|---|
| author | Pinho, Andreia G. |
| author2 | Cibrão, Jorge R. Silva, Nuno A. Monteiro, Susana Salgado, A. J. |
| author2_role | author author author author |
| author_facet | Pinho, Andreia G. Cibrão, Jorge R. Silva, Nuno A. Monteiro, Susana Salgado, A. J. |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Pinho, Andreia G.\"},{\"Person.name\":\"Cibrão, Jorge R.\"},{\"Person.name\":\"Silva, Nuno A.\"},{\"Person.name\":\"Monteiro, Susana\"},{\"Person.name\":\"Salgado, A. J.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Pinho, Andreia G. Cibrão, Jorge R. Silva, Nuno A. Monteiro, Susana Salgado, A. J. |
| datacite.date.Accepted.fl_str_mv | 2020-02-20T00:00:00Z |
| datacite.date.available.fl_str_mv | 2020-03-17T10:55:08Z |
| datacite.date.embargoed.fl_str_mv | 2020-03-17T10:55:08Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | central nervous system ischemic stroke mesenchymal stem cells Parkinson’s disease regeneration spinal cord injury secretome traumatic brain injury |
| datacite.titles.title.fl_str_mv | Cell secretome: basic insights and therapeutic opportunities for CNS disorders |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Pinho, Andreia G. Cibrão, Jorge R. Silva, Nuno A. Monteiro, Susana Salgado, A. J. |
| dc.date.Accepted.fl_str_mv | 2020-02-20T00:00:00Z |
| dc.date.available.fl_str_mv | 2020-03-17T10:55:08Z |
| dc.date.embargoed.fl_str_mv | 2020-03-17T10:55:08Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/64444 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Multidisciplinary Digital Publishing Institute |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.rights.rights.copyright.fl_str_mv | openAccess |
| dc.subject.none.fl_str_mv | central nervous system ischemic stroke mesenchymal stem cells Parkinson’s disease regeneration spinal cord injury secretome traumatic brain injury |
| dc.title.fl_str_mv | Cell secretome: basic insights and therapeutic opportunities for CNS disorders |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Transplantation of stem cells, in particular mesenchymal stem cells (MSCs), stands as a promising therapy for trauma, stroke or neurodegenerative conditions such as spinal cord or traumatic brain injuries (SCI or TBI), ischemic stroke (IS), or Parkinson’s disease (PD). Over the last few years, cell transplantation-based approaches have started to focus on the use of cell byproducts, with a strong emphasis on cell secretome. Having this in mind, the present review discusses the current state of the art of secretome-based therapy applications in different central nervous system (CNS) pathologies. For this purpose, the following topics are discussed: (1) What are the main cell secretome sources, composition, and associated collection techniques; (2) Possible differences of the therapeutic potential of the protein and vesicular fraction of the secretome; and (3) Impact of the cell secretome on CNS-related problems such as SCI, TBI, IS, and PD. With this, we aim to clarify some of the main questions that currently exist in the field of secretome-based therapies and consequently gain new knowledge that may help in the clinical application of secretome in CNS disorders. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/df0b443d-bfd3-48f2-b45e-2042c9838069/download |
| id | rum_ecf482d9759a71d615fda00a578a33f1 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/64444 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/64444 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Pinho, Andreia G. Cibrão, Jorge R. Silva, Nuno A. Monteiro, Susana Salgado, A. J. |
| publishDate | 2020 |
| publisher.none.fl_str_mv | Multidisciplinary Digital Publishing Institute |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engMultidisciplinary Digital Publishing InstituteporTransplantation of stem cells, in particular mesenchymal stem cells (MSCs), stands as a promising therapy for trauma, stroke or neurodegenerative conditions such as spinal cord or traumatic brain injuries (SCI or TBI), ischemic stroke (IS), or Parkinson’s disease (PD). Over the last few years, cell transplantation-based approaches have started to focus on the use of cell byproducts, with a strong emphasis on cell secretome. Having this in mind, the present review discusses the current state of the art of secretome-based therapy applications in different central nervous system (CNS) pathologies. For this purpose, the following topics are discussed: (1) What are the main cell secretome sources, composition, and associated collection techniques; (2) Possible differences of the therapeutic potential of the protein and vesicular fraction of the secretome; and (3) Impact of the cell secretome on CNS-related problems such as SCI, TBI, IS, and PD. With this, we aim to clarify some of the main questions that currently exist in the field of secretome-based therapies and consequently gain new knowledge that may help in the clinical application of secretome in CNS disorders.application/pdfporCell secretome: basic insights and therapeutic opportunities for CNS disordersPinho, Andreia G.Cibrão, Jorge R.Silva, Nuno A.Monteiro, SusanaSalgado, A. J.HostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptDOIIsPartOf10.3390/ph130200312020-03-17T10:55:08Z2020-02-202020-03-02T12:39:54Z2020-02-20T00:00:00ZHandlehttps://hdl.handle.net/1822/64444http://purl.org/coar/access_right/c_abf2open accesscentral nervous systemischemic strokemesenchymal stem cellsParkinson’s diseaseregenerationspinal cord injurysecretometraumatic brain injury719508 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2020-02-20http://creativecommons.org/licenses/by/4.0/openAccesshttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/df0b443d-bfd3-48f2-b45e-2042c9838069/download |
| spellingShingle | Cell secretome: basic insights and therapeutic opportunities for CNS disorders Pinho, Andreia G. central nervous system ischemic stroke mesenchymal stem cells Parkinson’s disease regeneration spinal cord injury secretome traumatic brain injury |
| status | SINGLETON |
| subject.fl_str_mv | central nervous system ischemic stroke mesenchymal stem cells Parkinson’s disease regeneration spinal cord injury secretome traumatic brain injury |
| title | Cell secretome: basic insights and therapeutic opportunities for CNS disorders |
| title_full | Cell secretome: basic insights and therapeutic opportunities for CNS disorders |
| title_fullStr | Cell secretome: basic insights and therapeutic opportunities for CNS disorders |
| title_full_unstemmed | Cell secretome: basic insights and therapeutic opportunities for CNS disorders |
| title_short | Cell secretome: basic insights and therapeutic opportunities for CNS disorders |
| title_sort | Cell secretome: basic insights and therapeutic opportunities for CNS disorders |
| topic | central nervous system ischemic stroke mesenchymal stem cells Parkinson’s disease regeneration spinal cord injury secretome traumatic brain injury |
| topic_facet | central nervous system ischemic stroke mesenchymal stem cells Parkinson’s disease regeneration spinal cord injury secretome traumatic brain injury |
| url | https://hdl.handle.net/1822/64444 |
| visible | 1 |