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Magnetically activated electroactive microenvironments for skeletal muscle tissue regeneration

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Resumo:This work reports on magnetoelectric biomaterials suitable for effective proliferation and differentiation of myoblast in a biomimetic microenvironment providing the electromechanical stimuli associated with this tissue in the human body. Magnetoelectric films are obtained by solvent casting through the combination of a piezoelectric polymer, poly(vinylidene fluoride-trifluoro-ethylene), and magnetostrictive particles (CoFe2O4). The nonpoled and poled (with negative and positive surface charge) magnetoelectric composites are used to investigate their influence on C2C12 myoblast adhesion, proliferation, and differentiation. It is demonstrated that the proliferation and differentiation of the cells are enhanced by the application of mechanical and/or electrical stimulation, with higher values of maturation index under mechanoelectrical stimuli. These results show that magnetoelectric cell stimulation is a full potential approach for skeletal muscle tissue engineering applications
Autores principais:Ribeiro, Sylvie Oliveira
Outros Autores:Ribeiro, C.; Carvalho, E. O.; Tubio, C. R.; Castro, N.; Pereira, Nelson; Correia, V.; Gomes, Andreia C; Lanceros-Méndez, S.
Assunto:Magnetoelectric biomaterials Muscle tissue engineering Mechanoelectrical stimuli Myotubes bioreactors bioreactors myotubes Ciências Médicas::Biotecnologia Médica Engenharia e Tecnologia::Engenharia Médica
Ano:2020
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho

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