Publicação
Low cost microfluidic device for partial cell separation: micromilling approach
| Resumo: | Several studies have already demonstrated that it is possible to perform blood flow studies in microfluidic systems fabricated by using low-cost techniques. However, most of these techniques do not produce microchannels smaller than 100 microns and as a result they have several limitations related to blood cell separation. Recently, manufacturers have been able to produce milling tools smaller than 100 microns, which consequently have promoted the ability of micromilling machines to fabricate microfluidic devices able to perform separation of red blood cells (RBCs) from plasma. In this work, we show the ability of a micromilling machine to manufacture microchannels with dimensions down to 30 microns. Additionally, we show for the first time the ability of the proposed microfluidic device to enhance the cell-free layer close to the walls, leading to perform partial separation of RBCs from plasma. |
|---|---|
| Autores principais: | Lopes, Raquel |
| Outros Autores: | Rodrigues, Raquel O.; Pinho, Diana; Garcia, Valdemar; Schütte, Helmut; Lima, Rui Alberto Madeira Macedo; Gassmann, Stefan |
| Assunto: | Micromilling Microfluidic device Nonlithographic technique Red blood cells Cell-free layer |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | comunicação em conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1866877634204401664 |
|---|---|
| author | Lopes, Raquel |
| author2 | Rodrigues, Raquel O. Pinho, Diana Garcia, Valdemar Schütte, Helmut Lima, Rui Alberto Madeira Macedo Gassmann, Stefan |
| author2_role | author author author author author author |
| author_facet | Lopes, Raquel Rodrigues, Raquel O. Pinho, Diana Garcia, Valdemar Schütte, Helmut Lima, Rui Alberto Madeira Macedo Gassmann, Stefan |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Lopes, Raquel\"},{\"Person.name\":\"Rodrigues, Raquel O.\"},{\"Person.name\":\"Pinho, Diana\"},{\"Person.name\":\"Garcia, Valdemar\"},{\"Person.name\":\"Schütte, Helmut\"},{\"Person.name\":\"Lima, Rui Alberto Madeira Macedo\"},{\"Person.name\":\"Gassmann, Stefan\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Lopes, Raquel Rodrigues, Raquel O. Pinho, Diana Garcia, Valdemar Schütte, Helmut Lima, Rui Alberto Madeira Macedo Gassmann, Stefan |
| datacite.date.Accepted.fl_str_mv | 2015-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2018-02-28T09:42:15Z |
| datacite.date.embargoed.fl_str_mv | 2018-02-28T09:42:15Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Micromilling Microfluidic device Nonlithographic technique Red blood cells Cell-free layer |
| datacite.titles.title.fl_str_mv | Low cost microfluidic device for partial cell separation: micromilling approach |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Lopes, Raquel Rodrigues, Raquel O. Pinho, Diana Garcia, Valdemar Schütte, Helmut Lima, Rui Alberto Madeira Macedo Gassmann, Stefan |
| dc.date.Accepted.fl_str_mv | 2015-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2018-02-28T09:42:15Z |
| dc.date.embargoed.fl_str_mv | 2018-02-28T09:42:15Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/51178 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | IEEE |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Micromilling Microfluidic device Nonlithographic technique Red blood cells Cell-free layer |
| dc.title.fl_str_mv | Low cost microfluidic device for partial cell separation: micromilling approach |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_5794 |
| description | Several studies have already demonstrated that it is possible to perform blood flow studies in microfluidic systems fabricated by using low-cost techniques. However, most of these techniques do not produce microchannels smaller than 100 microns and as a result they have several limitations related to blood cell separation. Recently, manufacturers have been able to produce milling tools smaller than 100 microns, which consequently have promoted the ability of micromilling machines to fabricate microfluidic devices able to perform separation of red blood cells (RBCs) from plasma. In this work, we show the ability of a micromilling machine to manufacture microchannels with dimensions down to 30 microns. Additionally, we show for the first time the ability of the proposed microfluidic device to enhance the cell-free layer close to the walls, leading to perform partial separation of RBCs from plasma. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | conferencePaper |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/d963ddf3-11ae-4381-962a-146378a3a6ea/download |
| id | rum_ee89bc2ebd8b111a08b5a4aa89a628ab |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/51178 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/51178 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Lopes, Raquel Rodrigues, Raquel O. Pinho, Diana Garcia, Valdemar Schütte, Helmut Lima, Rui Alberto Madeira Macedo Gassmann, Stefan |
| publishDate | 2015 |
| publisher.none.fl_str_mv | IEEE |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engIEEEporSeveral studies have already demonstrated that it is possible to perform blood flow studies in microfluidic systems fabricated by using low-cost techniques. However, most of these techniques do not produce microchannels smaller than 100 microns and as a result they have several limitations related to blood cell separation. Recently, manufacturers have been able to produce milling tools smaller than 100 microns, which consequently have promoted the ability of micromilling machines to fabricate microfluidic devices able to perform separation of red blood cells (RBCs) from plasma. In this work, we show the ability of a micromilling machine to manufacture microchannels with dimensions down to 30 microns. Additionally, we show for the first time the ability of the proposed microfluidic device to enhance the cell-free layer close to the walls, leading to perform partial separation of RBCs from plasma.application/pdfporLow cost microfluidic device for partial cell separation: micromilling approachLopes, RaquelRodrigues, Raquel O.Pinho, DianaGarcia, ValdemarSchütte, HelmutLima, Rui Alberto Madeira MacedoGassmann, StefanHostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptDOIIsPartOf10.1109/ICIT.2015.71255942018-02-28T09:42:15Z20152015-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/51178http://purl.org/coar/access_right/c_abf2open accessMicromillingMicrofluidic deviceNonlithographic techniqueRed blood cellsCell-free layer1280606 bytesother research producthttp://purl.org/coar/resource_type/c_5794conference paperhttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/d963ddf3-11ae-4381-962a-146378a3a6ea/download |
| spellingShingle | Low cost microfluidic device for partial cell separation: micromilling approach Lopes, Raquel Micromilling Microfluidic device Nonlithographic technique Red blood cells Cell-free layer |
| status | SINGLETON |
| subject.fl_str_mv | Micromilling Microfluidic device Nonlithographic technique Red blood cells Cell-free layer |
| title | Low cost microfluidic device for partial cell separation: micromilling approach |
| title_full | Low cost microfluidic device for partial cell separation: micromilling approach |
| title_fullStr | Low cost microfluidic device for partial cell separation: micromilling approach |
| title_full_unstemmed | Low cost microfluidic device for partial cell separation: micromilling approach |
| title_short | Low cost microfluidic device for partial cell separation: micromilling approach |
| title_sort | Low cost microfluidic device for partial cell separation: micromilling approach |
| topic | Micromilling Microfluidic device Nonlithographic technique Red blood cells Cell-free layer |
| topic_facet | Micromilling Microfluidic device Nonlithographic technique Red blood cells Cell-free layer |
| url | https://hdl.handle.net/1822/51178 |
| visible | 1 |