Publicação
Magnetic micellar nanovehicles: prospects of multifunctional hybrid systems for precision theranostics
| Resumo: | Hybrid nanoarchitectures such as magnetic polymeric micelles (MPMs) are among the most promising nanotechnology-enabled materials for biomedical applications combining the benefits of polymeric micelles and magnetic nanoparticles within a single bioinstructive system. MPMs are formed by the self-assembly of polymer amphiphiles above the critical micelle concentration, generating a colloidal structure with a hydrophobic core and a hydrophilic shell incorporating magnetic particles (MNPs) in one of the segments. MPMs have been investigated most prominently as contrast agents for magnetic resonance imaging (MRI), as heat generators in hyperthermia treatments, and as magnetic-susceptible nanocarriers for the delivery and release of therapeutic agents. The versatility of MPMs constitutes a powerful route to ultrasensitive, precise, and multifunctional diagnostic and therapeutic vehicles for the treatment of a wide range of pathologies. Although MPMs have been significantly explored for MRI and cancer therapy, MPMs are multipurpose functional units, widening their applicability into less expected fields of research such as bioengineering and regenerative medicine. Herein, we aim to review published reports of the last five years about MPMs concerning their structure and fabrication methods as well as their current and foreseen expectations for advanced biomedical applications. |
|---|---|
| Autores principais: | Miranda, Margarida Silva |
| Outros Autores: | Almeida, Ana Filipa Martins; Gomes, Manuela E.; Rodrigues, Márcia T. |
| Assunto: | Hybrid nanosystems Magnetic polymeric micelles Polymeric micelles Magnetic nanoparticles Imaging Drug delivery Target delivery Nanotherapeutics Hyperthermia Magnetically assisted technologies |
| Ano: | 2022 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1864251793247043584 |
|---|---|
| author | Miranda, Margarida Silva |
| author2 | Almeida, Ana Filipa Martins Gomes, Manuela E. Rodrigues, Márcia T. |
| author2_role | author author author |
| author_facet | Miranda, Margarida Silva Almeida, Ana Filipa Martins Gomes, Manuela E. Rodrigues, Márcia T. |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Miranda, Margarida Silva\"},{\"Person.name\":\"Almeida, Ana Filipa Martins\"},{\"Person.name\":\"Gomes, Manuela E.\"},{\"Person.name\":\"Rodrigues, Márcia T.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Miranda, Margarida Silva Almeida, Ana Filipa Martins Gomes, Manuela E. Rodrigues, Márcia T. |
| datacite.date.Accepted.fl_str_mv | 2022-10-04T00:00:00Z |
| datacite.date.available.fl_str_mv | 2022-11-24T16:04:38Z |
| datacite.date.embargoed.fl_str_mv | 2022-11-24T16:04:38Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Hybrid nanosystems Magnetic polymeric micelles Polymeric micelles Magnetic nanoparticles Imaging Drug delivery Target delivery Nanotherapeutics Hyperthermia Magnetically assisted technologies |
| datacite.titles.title.fl_str_mv | Magnetic micellar nanovehicles: prospects of multifunctional hybrid systems for precision theranostics |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Miranda, Margarida Silva Almeida, Ana Filipa Martins Gomes, Manuela E. Rodrigues, Márcia T. |
| dc.date.Accepted.fl_str_mv | 2022-10-04T00:00:00Z |
| dc.date.available.fl_str_mv | 2022-11-24T16:04:38Z |
| dc.date.embargoed.fl_str_mv | 2022-11-24T16:04:38Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/80814 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Multidisciplinary Digital Publishing Institute (MDPI) |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.rights.rights.copyright.fl_str_mv | openAccess |
| dc.subject.none.fl_str_mv | Hybrid nanosystems Magnetic polymeric micelles Polymeric micelles Magnetic nanoparticles Imaging Drug delivery Target delivery Nanotherapeutics Hyperthermia Magnetically assisted technologies |
| dc.title.fl_str_mv | Magnetic micellar nanovehicles: prospects of multifunctional hybrid systems for precision theranostics |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Hybrid nanoarchitectures such as magnetic polymeric micelles (MPMs) are among the most promising nanotechnology-enabled materials for biomedical applications combining the benefits of polymeric micelles and magnetic nanoparticles within a single bioinstructive system. MPMs are formed by the self-assembly of polymer amphiphiles above the critical micelle concentration, generating a colloidal structure with a hydrophobic core and a hydrophilic shell incorporating magnetic particles (MNPs) in one of the segments. MPMs have been investigated most prominently as contrast agents for magnetic resonance imaging (MRI), as heat generators in hyperthermia treatments, and as magnetic-susceptible nanocarriers for the delivery and release of therapeutic agents. The versatility of MPMs constitutes a powerful route to ultrasensitive, precise, and multifunctional diagnostic and therapeutic vehicles for the treatment of a wide range of pathologies. Although MPMs have been significantly explored for MRI and cancer therapy, MPMs are multipurpose functional units, widening their applicability into less expected fields of research such as bioengineering and regenerative medicine. Herein, we aim to review published reports of the last five years about MPMs concerning their structure and fabrication methods as well as their current and foreseen expectations for advanced biomedical applications. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/98883154-7e7a-4922-abf8-4a7af7b10259/download |
| id | rum_f0fd7f5d2d2ca5be71ea3adb564d30a4 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/80814 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/80814 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Miranda, Margarida Silva Almeida, Ana Filipa Martins Gomes, Manuela E. Rodrigues, Márcia T. |
| publishDate | 2022 |
| publisher.none.fl_str_mv | Multidisciplinary Digital Publishing Institute (MDPI) |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engMultidisciplinary Digital Publishing Institute (MDPI)porHybrid nanoarchitectures such as magnetic polymeric micelles (MPMs) are among the most promising nanotechnology-enabled materials for biomedical applications combining the benefits of polymeric micelles and magnetic nanoparticles within a single bioinstructive system. MPMs are formed by the self-assembly of polymer amphiphiles above the critical micelle concentration, generating a colloidal structure with a hydrophobic core and a hydrophilic shell incorporating magnetic particles (MNPs) in one of the segments. MPMs have been investigated most prominently as contrast agents for magnetic resonance imaging (MRI), as heat generators in hyperthermia treatments, and as magnetic-susceptible nanocarriers for the delivery and release of therapeutic agents. The versatility of MPMs constitutes a powerful route to ultrasensitive, precise, and multifunctional diagnostic and therapeutic vehicles for the treatment of a wide range of pathologies. Although MPMs have been significantly explored for MRI and cancer therapy, MPMs are multipurpose functional units, widening their applicability into less expected fields of research such as bioengineering and regenerative medicine. Herein, we aim to review published reports of the last five years about MPMs concerning their structure and fabrication methods as well as their current and foreseen expectations for advanced biomedical applications.application/pdfporMagnetic micellar nanovehicles: prospects of multifunctional hybrid systems for precision theranosticsMiranda, Margarida SilvaAlmeida, Ana Filipa MartinsGomes, Manuela E.Rodrigues, Márcia T.HostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptISSNIsPartOf1661-6596DOIIsPartOf10.3390/ijms2319117932022-11-24T16:04:38Z2022-10-042022-10-13T12:58:29Z2022-10-04T00:00:00ZHandlehttps://hdl.handle.net/1822/80814http://purl.org/coar/access_right/c_abf2open accessHybrid nanosystemsMagnetic polymeric micellesPolymeric micellesMagnetic nanoparticlesImagingDrug deliveryTarget deliveryNanotherapeuticsHyperthermiaMagnetically assisted technologies9317167 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2022-10-04http://creativecommons.org/licenses/by/4.0/openAccesshttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/98883154-7e7a-4922-abf8-4a7af7b10259/download |
| spellingShingle | Magnetic micellar nanovehicles: prospects of multifunctional hybrid systems for precision theranostics Miranda, Margarida Silva Hybrid nanosystems Magnetic polymeric micelles Polymeric micelles Magnetic nanoparticles Imaging Drug delivery Target delivery Nanotherapeutics Hyperthermia Magnetically assisted technologies |
| subject.fl_str_mv | Hybrid nanosystems Magnetic polymeric micelles Polymeric micelles Magnetic nanoparticles Imaging Drug delivery Target delivery Nanotherapeutics Hyperthermia Magnetically assisted technologies |
| title | Magnetic micellar nanovehicles: prospects of multifunctional hybrid systems for precision theranostics |
| title_full | Magnetic micellar nanovehicles: prospects of multifunctional hybrid systems for precision theranostics |
| title_fullStr | Magnetic micellar nanovehicles: prospects of multifunctional hybrid systems for precision theranostics |
| title_full_unstemmed | Magnetic micellar nanovehicles: prospects of multifunctional hybrid systems for precision theranostics |
| title_short | Magnetic micellar nanovehicles: prospects of multifunctional hybrid systems for precision theranostics |
| title_sort | Magnetic micellar nanovehicles: prospects of multifunctional hybrid systems for precision theranostics |
| topic | Hybrid nanosystems Magnetic polymeric micelles Polymeric micelles Magnetic nanoparticles Imaging Drug delivery Target delivery Nanotherapeutics Hyperthermia Magnetically assisted technologies |
| topic_facet | Hybrid nanosystems Magnetic polymeric micelles Polymeric micelles Magnetic nanoparticles Imaging Drug delivery Target delivery Nanotherapeutics Hyperthermia Magnetically assisted technologies |
| url | https://hdl.handle.net/1822/80814 |
| visible | 1 |