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Fluorescence in situ hybridization, comparative genomic hybridization, and other molecular biology techniques in the analysis of effusions

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Resumo:Over the last 20 yr, the introduction of immunocytochemistry as a diagnostic tool has dramatically revolutionized diagnostic pathology. With the introduction of molecular methods as part of the diagnostic armamentarium, the practicing pathologist is facing the new challenge of grasping novel concepts of the molecular cytogenetics era. Herein, we review the diagnostic contribution of ancillary molecular techniques, including fluorescent and chromogenic in situ hybridization, telomerase assays, loss of heterozygosity, comparative genomic hybridization (CGH), and microarray-based CGH, for the practicing cytopathologists and discuss how these techniques will help pathologists in decision-making.
Autores principais:Reis-Filho, Jorge S.
Outros Autores:de Landér Schmitt, Fernando Carlos
Assunto:Ascitic Fluid Cytogenetic Analysis Humans In Situ Hybridization, Fluorescence Neoplasm Metastasis Nucleic Acid Hybridization Pleural Effusion, Malignant Telomerase Loss of Heterozygosity Oligonucleotide Array Sequence Analysis in situ hybridization comparative genomic hybridization arrays comparative genomic hybridization effusion cytology mesotheliomas Ciências Médicas::Ciências da Saúde
Ano:2005
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso restrito
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho

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