Publicação
Controlled delivery achieved with bi-layer matrix devices produced by co-injection moulding
| Resumo: | The aim of this study was to design new soy protein-based bi-layered co-injection moulded matrix systems aimed to achieve controlled drug delivery. The devices consisted of a drug-free outer layer (skin) and a drug-containing core. The systems overcame the inherent disadvantage of non-linear release associated with diffusion-controlled single-layer matrix devices by providing additional releasing area with time to compensate for the decreasing release rate. As expected, the bi-layer devices presented a significant decrease in drug release rate when compared with a correspondent single layer matrix system. The skin thickness and the degree of crosslinking of the core appeared to be very important tools to tailor the release patterns. Furthermore, due to the amphoteric nature of the soy protein, the developed devices evidenced a pH-dependent behaviour. The mechanisms of drug release were also elucidated at two different pH values: i) pH 5.0, near the isoelectric point of soy (low matrix solubility); and ii) pH 7.4, physiological pH (high matrix solubility). Consequently, changing the release medium from pH 5.0 to pH 7.4 after two hours, led to an abrupt increase in drug release and the devices presented a typical controlled drug delivery profile: slow release/fast release. These evidences may provide for the development of individual systems with different release onsets that in combination may exhibit drug releases at predetermined times in a pre-programmed way. Another possibility is the production of three-layer devices presenting bimodal release profiles (fast release/slow release/fast release) by similar technologies. |
|---|---|
| Autores principais: | Vaz, Cláudia M. |
| Outros Autores: | Doeveren, P. F. N. M. van; Dias, Gustavo R.; Reis, R. L.; Cunha, A. M. |
| Assunto: | Bi-layer devices (Co-)injection moulding Drug delivery systems Soy protein Theophylline |
| Ano: | 2004 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1866877960118599680 |
|---|---|
| author | Vaz, Cláudia M. |
| author2 | Doeveren, P. F. N. M. van Dias, Gustavo R. Reis, R. L. Cunha, A. M. |
| author2_role | author author author author |
| author_facet | Vaz, Cláudia M. Doeveren, P. F. N. M. van Dias, Gustavo R. Reis, R. L. Cunha, A. M. |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Vaz, Cláudia M.\"},{\"Person.name\":\"Doeveren, P. F. N. M. van\"},{\"Person.name\":\"Dias, Gustavo R.\"},{\"Person.name\":\"Reis, R. L.\"},{\"Person.name\":\"Cunha, A. M.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Vaz, Cláudia M. Doeveren, P. F. N. M. van Dias, Gustavo R. Reis, R. L. Cunha, A. M. |
| datacite.date.Accepted.fl_str_mv | 2004-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2006-01-18T18:15:21Z |
| datacite.date.embargoed.fl_str_mv | 2006-01-18T18:15:21Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Bi-layer devices (Co-)injection moulding Drug delivery systems Soy protein Theophylline |
| datacite.titles.title.fl_str_mv | Controlled delivery achieved with bi-layer matrix devices produced by co-injection moulding |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Vaz, Cláudia M. Doeveren, P. F. N. M. van Dias, Gustavo R. Reis, R. L. Cunha, A. M. |
| dc.date.Accepted.fl_str_mv | 2004-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2006-01-18T18:15:21Z |
| dc.date.embargoed.fl_str_mv | 2006-01-18T18:15:21Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/4031 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Wiley |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Bi-layer devices (Co-)injection moulding Drug delivery systems Soy protein Theophylline |
| dc.title.fl_str_mv | Controlled delivery achieved with bi-layer matrix devices produced by co-injection moulding |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The aim of this study was to design new soy protein-based bi-layered co-injection moulded matrix systems aimed to achieve controlled drug delivery. The devices consisted of a drug-free outer layer (skin) and a drug-containing core. The systems overcame the inherent disadvantage of non-linear release associated with diffusion-controlled single-layer matrix devices by providing additional releasing area with time to compensate for the decreasing release rate. As expected, the bi-layer devices presented a significant decrease in drug release rate when compared with a correspondent single layer matrix system. The skin thickness and the degree of crosslinking of the core appeared to be very important tools to tailor the release patterns. Furthermore, due to the amphoteric nature of the soy protein, the developed devices evidenced a pH-dependent behaviour. The mechanisms of drug release were also elucidated at two different pH values: i) pH 5.0, near the isoelectric point of soy (low matrix solubility); and ii) pH 7.4, physiological pH (high matrix solubility). Consequently, changing the release medium from pH 5.0 to pH 7.4 after two hours, led to an abrupt increase in drug release and the devices presented a typical controlled drug delivery profile: slow release/fast release. These evidences may provide for the development of individual systems with different release onsets that in combination may exhibit drug releases at predetermined times in a pre-programmed way. Another possibility is the production of three-layer devices presenting bimodal release profiles (fast release/slow release/fast release) by similar technologies. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/7f0a3964-3a7a-4223-abb7-81e2939c1c19/download |
| id | rum_fc36a5c5e4d7ab4e04c7d8bfba3f06b2 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/4031 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/4031 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Vaz, Cláudia M. Doeveren, P. F. N. M. van Dias, Gustavo R. Reis, R. L. Cunha, A. M. |
| publishDate | 2004 |
| publisher.none.fl_str_mv | Wiley |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engWileyengThe aim of this study was to design new soy protein-based bi-layered co-injection moulded matrix systems aimed to achieve controlled drug delivery. The devices consisted of a drug-free outer layer (skin) and a drug-containing core. The systems overcame the inherent disadvantage of non-linear release associated with diffusion-controlled single-layer matrix devices by providing additional releasing area with time to compensate for the decreasing release rate. As expected, the bi-layer devices presented a significant decrease in drug release rate when compared with a correspondent single layer matrix system. The skin thickness and the degree of crosslinking of the core appeared to be very important tools to tailor the release patterns. Furthermore, due to the amphoteric nature of the soy protein, the developed devices evidenced a pH-dependent behaviour. The mechanisms of drug release were also elucidated at two different pH values: i) pH 5.0, near the isoelectric point of soy (low matrix solubility); and ii) pH 7.4, physiological pH (high matrix solubility). Consequently, changing the release medium from pH 5.0 to pH 7.4 after two hours, led to an abrupt increase in drug release and the devices presented a typical controlled drug delivery profile: slow release/fast release. These evidences may provide for the development of individual systems with different release onsets that in combination may exhibit drug releases at predetermined times in a pre-programmed way. Another possibility is the production of three-layer devices presenting bimodal release profiles (fast release/slow release/fast release) by similar technologies.application/pdfengControlled delivery achieved with bi-layer matrix devices produced by co-injection mouldingVaz, Cláudia M.Doeveren, P. F. N. M. vanDias, Gustavo R.Reis, R. L.Cunha, A. M.HostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptISSNIsPartOf1616-5187DOIIsPartOf10.1002/mabi.2003000602006-01-18T18:15:21Z20042004-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/4031http://purl.org/coar/access_right/c_abf2open accessBi-layer devices(Co-)injection mouldingDrug delivery systemsSoy proteinTheophylline256328 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/7f0a3964-3a7a-4223-abb7-81e2939c1c19/download |
| spellingShingle | Controlled delivery achieved with bi-layer matrix devices produced by co-injection moulding Vaz, Cláudia M. Bi-layer devices (Co-)injection moulding Drug delivery systems Soy protein Theophylline |
| status | SINGLETON |
| subject.fl_str_mv | Bi-layer devices (Co-)injection moulding Drug delivery systems Soy protein Theophylline |
| title | Controlled delivery achieved with bi-layer matrix devices produced by co-injection moulding |
| title_full | Controlled delivery achieved with bi-layer matrix devices produced by co-injection moulding |
| title_fullStr | Controlled delivery achieved with bi-layer matrix devices produced by co-injection moulding |
| title_full_unstemmed | Controlled delivery achieved with bi-layer matrix devices produced by co-injection moulding |
| title_short | Controlled delivery achieved with bi-layer matrix devices produced by co-injection moulding |
| title_sort | Controlled delivery achieved with bi-layer matrix devices produced by co-injection moulding |
| topic | Bi-layer devices (Co-)injection moulding Drug delivery systems Soy protein Theophylline |
| topic_facet | Bi-layer devices (Co-)injection moulding Drug delivery systems Soy protein Theophylline |
| url | https://hdl.handle.net/1822/4031 |
| visible | 1 |