Publicação
Será a síndrome metabólica um marcador de prognóstico em doentes com elevado risco cardiovascular? Um estudo de coorte a longo‐prazo
| Resumo: | Introduction: Obese patients are at higher cardiovascular risk in primary prevention. In secondary prevention, an obesity paradox has been reported. We analyzed a cohort of individuals from a previous cross‐sectional study on the impact of metabolic syndrome (MS) on coronary artery disease (CAD), aiming to assess the occurrence of cardiovascular events in a long follow‐up. Methods: We analyzed 296 individuals in a mean follow‐up of 6.9±2.2 years. Subjects were divided into four groups according to the presence of MS or CAD (defined as ≥70% coronary stenosis). Results: The study population had a mean age of 65±9 years at the beginning of the study; 59.5% were male, 55.7% had MS and 41.6% had CAD. During follow‐up 10.1% of the population suffered all‐cause death, 3.7% cardiovascular death, 14.2% cardiovascular readmission and 22.0% the composite outcome (mortality, acute coronary syndrome, coronary revascularization, stroke/transient ischemic attack or heart failure admission). There were no significant differences in any type of mortality. Patients with CAD had more readmissions and composite outcomes (log‐rank p<0.001 and p=0.001, respectively), but there was no difference according to the presence of MS. Only CAD was an independent predictor of cardiovascular admission (HR 3.21, 95% CI 1.66‐6.21) and composite outcomes (HR 2.41, 95% CI 1.44‐4.02). Conclusions: In patients with high cardiovascular risk or established CAD, the presence of MS is not associated with cerebral or cardiac events in long‐term follow‐up. |
|---|---|
| Autores principais: | Timóteo, Ana Teresa |
| Outros Autores: | Mota Carmo, Miguel; Mota Carmo, M; Soares, Cristina; Cruz Ferreira, Rui |
| Assunto: | Cardiovascular events Coronary artery disease Metabolic syndrome Prognosis Cardiology and Cardiovascular Medicine SDG 3 - Good Health and Well-being |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | português |
| Origem: | Repositório Institucional da UNL |
| _version_ | 1868982786610692096 |
|---|---|
| author | Timóteo, Ana Teresa |
| author2 | Mota Carmo, Miguel Mota Carmo, M Soares, Cristina Cruz Ferreira, Rui |
| author2_role | author author author author |
| author_facet | Timóteo, Ana Teresa Mota Carmo, Miguel Mota Carmo, M Soares, Cristina Cruz Ferreira, Rui |
| author_role | author |
| contributor_name_str_mv | Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Sociedade Portuguesa de Cardiologia | Elsevier RUN |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Timóteo, Ana Teresa\"},{\"Person.name\":\"Mota Carmo, Miguel\"},{\"Person.name\":\"Mota Carmo, M\",\"Person.identifier.orcid\":\"0000-0001-6865-4332\"},{\"Person.name\":\"Soares, Cristina\"},{\"Person.name\":\"Cruz Ferreira, Rui\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Sociedade Portuguesa de Cardiologia | Elsevier RUN |
| datacite.creators.creator.creatorName.fl_str_mv | Timóteo, Ana Teresa Mota Carmo, Miguel Mota Carmo, M Soares, Cristina Cruz Ferreira, Rui |
| datacite.date.Accepted.fl_str_mv | 2019-05-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2023-01-26T22:11:28Z |
| datacite.date.embargoed.fl_str_mv | 2023-01-26T22:11:28Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Cardiovascular events Coronary artery disease Metabolic syndrome Prognosis Cardiology and Cardiovascular Medicine SDG 3 - Good Health and Well-being |
| datacite.titles.title.fl_str_mv | Será a síndrome metabólica um marcador de prognóstico em doentes com elevado risco cardiovascular? Um estudo de coorte a longo‐prazo Is metabolic syndrome a prognostic marker in patients at high cardiovascular risk? A long‐term cohort study |
| dc.contributor.none.fl_str_mv | Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Sociedade Portuguesa de Cardiologia | Elsevier RUN |
| dc.creator.none.fl_str_mv | Timóteo, Ana Teresa Mota Carmo, Miguel Mota Carmo, M Soares, Cristina Cruz Ferreira, Rui |
| dc.date.Accepted.fl_str_mv | 2019-05-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2023-01-26T22:11:28Z |
| dc.date.embargoed.fl_str_mv | 2023-01-26T22:11:28Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10362/148216 |
| dc.language.none.fl_str_mv | por |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Cardiovascular events Coronary artery disease Metabolic syndrome Prognosis Cardiology and Cardiovascular Medicine SDG 3 - Good Health and Well-being |
| dc.title.fl_str_mv | Será a síndrome metabólica um marcador de prognóstico em doentes com elevado risco cardiovascular? Um estudo de coorte a longo‐prazo Is metabolic syndrome a prognostic marker in patients at high cardiovascular risk? A long‐term cohort study |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Introduction: Obese patients are at higher cardiovascular risk in primary prevention. In secondary prevention, an obesity paradox has been reported. We analyzed a cohort of individuals from a previous cross‐sectional study on the impact of metabolic syndrome (MS) on coronary artery disease (CAD), aiming to assess the occurrence of cardiovascular events in a long follow‐up. Methods: We analyzed 296 individuals in a mean follow‐up of 6.9±2.2 years. Subjects were divided into four groups according to the presence of MS or CAD (defined as ≥70% coronary stenosis). Results: The study population had a mean age of 65±9 years at the beginning of the study; 59.5% were male, 55.7% had MS and 41.6% had CAD. During follow‐up 10.1% of the population suffered all‐cause death, 3.7% cardiovascular death, 14.2% cardiovascular readmission and 22.0% the composite outcome (mortality, acute coronary syndrome, coronary revascularization, stroke/transient ischemic attack or heart failure admission). There were no significant differences in any type of mortality. Patients with CAD had more readmissions and composite outcomes (log‐rank p<0.001 and p=0.001, respectively), but there was no difference according to the presence of MS. Only CAD was an independent predictor of cardiovascular admission (HR 3.21, 95% CI 1.66‐6.21) and composite outcomes (HR 2.41, 95% CI 1.44‐4.02). Conclusions: In patients with high cardiovascular risk or established CAD, the presence of MS is not associated with cerebral or cardiac events in long‐term follow‐up. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://run.unl.pt/bitstreams/14b09ef9-59c0-43c4-9339-a1f7c38585a2/download |
| id | run_0918c5fb2c19fefbda72a962b4c3e06d |
| identifier.url.fl_str_mv | http://hdl.handle.net/10362/148216 |
| inst_facet_str | urn:organizationAcronym:unl{{{_:::_}}}Universidade Nova de Lisboa |
| instacron_str | unl |
| institution | Universidade Nova de Lisboa |
| instname_str | Universidade Nova de Lisboa |
| language | por |
| network_acronym_str | run |
| network_name_str | Repositório Institucional da UNL |
| oai_identifier_str | oai:run.unl.pt:10362/148216 |
| organization_str_mv | urn:organizationAcronym:unl |
| person_str_mv | Timóteo, Ana Teresa Mota Carmo, Miguel Mota Carmo, M Mota Carmo, M http://orcid.org/0000-0001-6865-4332 0000-0001-6865-4332 Soares, Cristina Cruz Ferreira, Rui |
| publishDate | 2019 |
| repo_facet_str | urn:repositoryAcronym:run{{{_:::_}}}Repositório Institucional da UNL |
| reponame_str | Repositório Institucional da UNL |
| repository_id_str | urn:repositoryAcronym:run |
| service_str_mv | urn:repositoryAcronym:run |
| spelling | porenIntroduction: Obese patients are at higher cardiovascular risk in primary prevention. In secondary prevention, an obesity paradox has been reported. We analyzed a cohort of individuals from a previous cross‐sectional study on the impact of metabolic syndrome (MS) on coronary artery disease (CAD), aiming to assess the occurrence of cardiovascular events in a long follow‐up. Methods: We analyzed 296 individuals in a mean follow‐up of 6.9±2.2 years. Subjects were divided into four groups according to the presence of MS or CAD (defined as ≥70% coronary stenosis). Results: The study population had a mean age of 65±9 years at the beginning of the study; 59.5% were male, 55.7% had MS and 41.6% had CAD. During follow‐up 10.1% of the population suffered all‐cause death, 3.7% cardiovascular death, 14.2% cardiovascular readmission and 22.0% the composite outcome (mortality, acute coronary syndrome, coronary revascularization, stroke/transient ischemic attack or heart failure admission). There were no significant differences in any type of mortality. Patients with CAD had more readmissions and composite outcomes (log‐rank p<0.001 and p=0.001, respectively), but there was no difference according to the presence of MS. Only CAD was an independent predictor of cardiovascular admission (HR 3.21, 95% CI 1.66‐6.21) and composite outcomes (HR 2.41, 95% CI 1.44‐4.02). Conclusions: In patients with high cardiovascular risk or established CAD, the presence of MS is not associated with cerebral or cardiac events in long‐term follow‐up.application/pdfptSerá a síndrome metabólica um marcador de prognóstico em doentes com elevado risco cardiovascular? Um estudo de coorte a longo‐prazoAlternativeTitleenIs metabolic syndrome a prognostic marker in patients at high cardiovascular risk? A long‐term cohort studyTimóteo, Ana TeresaMota Carmo, MiguelPersonalMota Carmo, MDSpacehttp://dspace.org/items/fd4b0895-e30a-4ffe-8784-0ba1105d55f6DSpacehttp://dspace.org/items/fd4b0895-e30a-4ffe-8784-0ba1105d55f6Mota CarmoMiguelORCIDhttp://orcid.org0000-0001-6865-4332Scopus Author IDhttps://www.scopus.com7004005362Soares, CristinaCruz Ferreira, RuiCentro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Sociedade Portuguesa de Cardiologia | ElsevierHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.ptISSNIsPartOf0870-2551URNIsPartOfPURE: 13816630URNIsPartOfPURE UUID: 2b4da48d-2954-4514-a277-2ab79e81e66bURNIsPartOfScopus: 85067250578URNIsPartOfWOS: 000472608800004URNIsPartOfPubMed: 31221487DOIIsPartOf10.1016/j.repc.2018.06.0122023-01-26T22:11:28Z2019-052019-05-01T00:00:00ZHandlehttp://hdl.handle.net/10362/148216http://purl.org/coar/access_right/c_abf2open accessCardiovascular eventsCoronary artery diseaseMetabolic syndromePrognosisCardiology and Cardiovascular MedicineSDG 3 - Good Health and Well-being832211 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/14b09ef9-59c0-43c4-9339-a1f7c38585a2/download |
| spellingShingle | Será a síndrome metabólica um marcador de prognóstico em doentes com elevado risco cardiovascular? Um estudo de coorte a longo‐prazo Timóteo, Ana Teresa Cardiovascular events Coronary artery disease Metabolic syndrome Prognosis Cardiology and Cardiovascular Medicine SDG 3 - Good Health and Well-being |
| status | SINGLETON |
| subject.fl_str_mv | Cardiovascular events Coronary artery disease Metabolic syndrome Prognosis Cardiology and Cardiovascular Medicine SDG 3 - Good Health and Well-being |
| title | Será a síndrome metabólica um marcador de prognóstico em doentes com elevado risco cardiovascular? Um estudo de coorte a longo‐prazo |
| title_full | Será a síndrome metabólica um marcador de prognóstico em doentes com elevado risco cardiovascular? Um estudo de coorte a longo‐prazo |
| title_fullStr | Será a síndrome metabólica um marcador de prognóstico em doentes com elevado risco cardiovascular? Um estudo de coorte a longo‐prazo |
| title_full_unstemmed | Será a síndrome metabólica um marcador de prognóstico em doentes com elevado risco cardiovascular? Um estudo de coorte a longo‐prazo |
| title_short | Será a síndrome metabólica um marcador de prognóstico em doentes com elevado risco cardiovascular? Um estudo de coorte a longo‐prazo |
| title_sort | Será a síndrome metabólica um marcador de prognóstico em doentes com elevado risco cardiovascular? Um estudo de coorte a longo‐prazo |
| topic | Cardiovascular events Coronary artery disease Metabolic syndrome Prognosis Cardiology and Cardiovascular Medicine SDG 3 - Good Health and Well-being |
| topic_facet | Cardiovascular events Coronary artery disease Metabolic syndrome Prognosis Cardiology and Cardiovascular Medicine SDG 3 - Good Health and Well-being |
| url | http://hdl.handle.net/10362/148216 |
| visible | 1 |