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Phylogeography of dengue virus serotype 4, Brazil, 2010-2011.

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Resumo:Dengue virus serotype 4 (DENV-4) reemerged in Roraima State, Brazil, 28 years after it was last detected in the country in 1982. To study the origin and evolution of this reemergence, full-length sequences were obtained for 16 DENV-4 isolates from northern (Roraima, Amazonas, Pará States) and northeastern (Bahia State) Brazil during the 2010 and 2011 dengue virus seasons and for an isolate from the 1982 epidemic in Roraima. Spatiotemporal dynamics of DENV-4 introductions in Brazil were applied to envelope genes and full genomes by using Bayesian phylogeographic analyses. An introduction of genotype I into Brazil from Southeast Asia was confirmed, and full genome phylogeographic analyses revealed multiple introductions of DENV-4 genotype II in Brazil, providing evidence for >3 introductions of this genotype within the last decade: 2 from Venezuela to Roraima and 1 from Colombia to Amazonas. The phylogeographic analysis of full genome data has demonstrated the origins of DENV-4 throughout Brazil.
Autores principais:Nunes, M. R. T.
Outros Autores:Faria, Nuno Rodrigues; Vasconcelos, H.B.; Medeiros, D. B. A.; de Lima, C. P. S.; Carvalho, V. L.; da Silva, E. V. P.; Cardoso, J.F.; Sousa Jr., E. C.; Nunes, K.N.B.; Rodrigues, S. G.; Abecasis, Ana; Suchard, M. A.; Lemey, Philippe; Vasconcelos, P. F. C.
Assunto:Genetics Ecology, Evolution, Behavior and Systematics Virology Infectious Diseases SDG 3 - Good Health and Well-being
Ano:2012
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Universidade Nova de Lisboa
Idioma:inglês
Origem:Repositório Institucional da UNL

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