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Impact of different strains of cannabis sativa L. on extract composition

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Resumo:Cannabis sativa L. has been used by humans for various purposes, including food, medicine, and religious rituals. Its key components are cannabinoids like cannabidiol (CBD), cannabinol (CBN), and Δ9-Tetrahydrocannabinol (Δ9-THC), the psychoactive compound. Despite controversy due to THC's addictive properties, cannabis has proven medicinal value for treating pain, chemotherapy-related symptoms, multiple sclerosis, and Acquired Immunodeficiency Syndrome (AIDS). It also shows potential for treating conditions like Post Traumatic Stress Disorder (PTSD), anorexia, Tourette’s syndrome, and sleep disorders. This dissertation aims to explore how cannabis genetics affect the composition of its extracts. It involved visual characterization of flowers, cannabinoid and terpene analysis through chromatography techniques, and statistical analyses like ANOVA, T-tests, and Principal Component Analysis (PCA). Additionally, the study examined how different agricultural methods influence the same cannabis strain. It was possible to conclude that every strain of cannabis flowers presents a different visual characterization and size distribution, since it’s a natural matrix. Additionally, the bud size does not seem to show a correlation to the cannabinoid content or extraction yield. Cannabis flowers present significant differences in their total Tetrahydrocannabinol (THC) content and strains grown indoors present higher concentrations. Cannabis oils presented a high content of cannabinoids and without significant differences, possible due to solvent saturation. Ethanol extraction at room temperature yields reached up to 31,96% (gflower/gextract) and Total THC yields were as high as 94,64%. The terpene analysis showed that cannabis flowers present 2-5% of terpenes and oils up to 12%. The same strain of cannabis, grown in different conditions, showed no significant differences, both in cannabinoid content as well as terpene profiles.
Autores principais:Sousa, Sofia Salavisa Avelar de
Assunto:Cannabis sativa L. medical cannabis cannabinoids terpenes HPLC Gas Chromatography
Ano:2024
País:Portugal
Tipo de documento:dissertação de mestrado
Tipo de acesso:acesso embargado
Instituição associada:Universidade Nova de Lisboa
Idioma:inglês
Origem:Repositório Institucional da UNL

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