Publicação
Dysmetabolism and Sleep Fragmentation in Obstructive Sleep Apnea Patients Run Independently of High Caffeine Consumption
| Resumo: | Daytime hypersomnolence, the prime feature of obstructive sleep apnea (OSA), frequently leads to high coffee consumption. Nevertheless, some clinicians ask for patients’ caffeine avoidance. Caffeinated drinks are sometimes associated with more severe OSA. However, these effects are not consensual. Here we investigated the effect of caffeine consumption on sleep architecture and apnea/hypopnea index in OSA. Also, the impact of caffeine on variables related with dysmetabolism, dyslipidemia, and sympathetic nervous system (SNS) dysfunction were investigated. A total of 65 patients diagnosed with OSA and 32 without OSA were included after given written informed consent. Polysomnographic studies were performed. Blood was collected to quantify caffeine and its metabolites in plasma and biochemical parameters. 24 h urine samples were collected for catecholamines measurement. Statistical analyses were performed by SPSS: (1) non-parametric Mann-Whitney test to compare variables between controls and OSA; (2) multivariate logistic regression testing the effect of caffeine on sets of variables in the 2 groups; and (3) Spearmans’ correlation between caffeine levels and comorbidities in patients with OSA. As expected OSA development is associated with dyslipidemia, dysmetabolism, SNS dysfunction, and sleep fragmentation. There was also a significant increase in plasma caffeine levels in the OSA group. However, the higher consumption of caffeine by OSA patients do not alter any of these associations. These results showed that there is no apparent rationale for caffeine avoidance in chronic consumers with OSA. |
|---|---|
| Autores principais: | Conde, Sílvia V. |
| Outros Autores: | V Conde, Silvia; Martins, Fátima O.; Dias, Sara S.; Pinto, Paula; Bárbara, Cristina; Monteiro, Emília C.; Monteiro, E.C. |
| Assunto: | apnea/hipopnea index caffeine dysmetabolism obstructive sleep apnea sleep architecture catecholamines Food Science Nutrition and Dietetics |
| Ano: | 2022 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| _version_ | 1868415257363349504 |
|---|---|
| author | Conde, Sílvia V. |
| author2 | V Conde, Silvia Martins, Fátima O. Dias, Sara S. Pinto, Paula Bárbara, Cristina Monteiro, Emília C. Monteiro, E.C. |
| author2_role | author author author author author author author |
| author_facet | Conde, Sílvia V. V Conde, Silvia Martins, Fátima O. Dias, Sara S. Pinto, Paula Bárbara, Cristina Monteiro, Emília C. Monteiro, E.C. |
| author_role | author |
| contributor_name_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) MDPI AG RUN |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Conde, Sílvia V.\"},{\"Person.name\":\"V Conde, Silvia\",\"Person.identifier.orcid\":\"0000-0002-5920-5700\"},{\"Person.name\":\"Martins, Fátima O.\"},{\"Person.name\":\"Dias, Sara S.\"},{\"Person.name\":\"Pinto, Paula\"},{\"Person.name\":\"Bárbara, Cristina\"},{\"Person.name\":\"Monteiro, Emília C.\"},{\"Person.name\":\"Monteiro, E.C.\",\"Person.identifier.orcid\":\"0000-0002-0570-0765\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) MDPI AG RUN |
| datacite.creators.creator.creatorName.fl_str_mv | Conde, Sílvia V. V Conde, Silvia Martins, Fátima O. Dias, Sara S. Pinto, Paula Bárbara, Cristina Monteiro, Emília C. Monteiro, E.C. |
| datacite.date.Accepted.fl_str_mv | 2022-04-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2022-04-08T22:36:03Z |
| datacite.date.embargoed.fl_str_mv | 2022-04-08T22:36:03Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | apnea/hipopnea index caffeine dysmetabolism obstructive sleep apnea sleep architecture catecholamines Food Science Nutrition and Dietetics |
| datacite.titles.title.fl_str_mv | Dysmetabolism and Sleep Fragmentation in Obstructive Sleep Apnea Patients Run Independently of High Caffeine Consumption |
| dc.contributor.none.fl_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) MDPI AG RUN |
| dc.creator.none.fl_str_mv | Conde, Sílvia V. V Conde, Silvia Martins, Fátima O. Dias, Sara S. Pinto, Paula Bárbara, Cristina Monteiro, Emília C. Monteiro, E.C. |
| dc.date.Accepted.fl_str_mv | 2022-04-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2022-04-08T22:36:03Z |
| dc.date.embargoed.fl_str_mv | 2022-04-08T22:36:03Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10362/136120 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | apnea/hipopnea index caffeine dysmetabolism obstructive sleep apnea sleep architecture catecholamines Food Science Nutrition and Dietetics |
| dc.title.fl_str_mv | Dysmetabolism and Sleep Fragmentation in Obstructive Sleep Apnea Patients Run Independently of High Caffeine Consumption |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Daytime hypersomnolence, the prime feature of obstructive sleep apnea (OSA), frequently leads to high coffee consumption. Nevertheless, some clinicians ask for patients’ caffeine avoidance. Caffeinated drinks are sometimes associated with more severe OSA. However, these effects are not consensual. Here we investigated the effect of caffeine consumption on sleep architecture and apnea/hypopnea index in OSA. Also, the impact of caffeine on variables related with dysmetabolism, dyslipidemia, and sympathetic nervous system (SNS) dysfunction were investigated. A total of 65 patients diagnosed with OSA and 32 without OSA were included after given written informed consent. Polysomnographic studies were performed. Blood was collected to quantify caffeine and its metabolites in plasma and biochemical parameters. 24 h urine samples were collected for catecholamines measurement. Statistical analyses were performed by SPSS: (1) non-parametric Mann-Whitney test to compare variables between controls and OSA; (2) multivariate logistic regression testing the effect of caffeine on sets of variables in the 2 groups; and (3) Spearmans’ correlation between caffeine levels and comorbidities in patients with OSA. As expected OSA development is associated with dyslipidemia, dysmetabolism, SNS dysfunction, and sleep fragmentation. There was also a significant increase in plasma caffeine levels in the OSA group. However, the higher consumption of caffeine by OSA patients do not alter any of these associations. These results showed that there is no apparent rationale for caffeine avoidance in chronic consumers with OSA. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://run.unl.pt/bitstreams/f71f1c2a-050e-4614-97d6-90d605ad3a80/download |
| id | run_33cda68071e980cf995f61ba5fe72870 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10362/136120 |
| instacron_str | unl |
| institution | Universidade Nova de Lisboa |
| instname_str | Universidade Nova de Lisboa |
| language | eng |
| network_acronym_str | run |
| network_name_str | Repositório Institucional da UNL |
| oai_identifier_str | oai:run.unl.pt:10362/136120 |
| organization_str_mv | urn:organizationAcronym:unl |
| person_str_mv | Conde, Sílvia V. V Conde, Silvia V Conde, Silvia https://www.ciencia-id.pt/561E-CF29-600A 561E-CF29-600A http://orcid.org/0000-0002-5920-5700 0000-0002-5920-5700 Martins, Fátima O. Dias, Sara S. Pinto, Paula Bárbara, Cristina Monteiro, Emília C. Monteiro, E.C. Monteiro, E.C. https://www.ciencia-id.pt/5918-54A6-FAA0 5918-54A6-FAA0 http://orcid.org/0000-0002-0570-0765 0000-0002-0570-0765 |
| publishDate | 2022 |
| reponame_str | Repositório Institucional da UNL |
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| service_str_mv | urn:repositoryAcronym:run |
| spelling | engenDaytime hypersomnolence, the prime feature of obstructive sleep apnea (OSA), frequently leads to high coffee consumption. Nevertheless, some clinicians ask for patients’ caffeine avoidance. Caffeinated drinks are sometimes associated with more severe OSA. However, these effects are not consensual. Here we investigated the effect of caffeine consumption on sleep architecture and apnea/hypopnea index in OSA. Also, the impact of caffeine on variables related with dysmetabolism, dyslipidemia, and sympathetic nervous system (SNS) dysfunction were investigated. A total of 65 patients diagnosed with OSA and 32 without OSA were included after given written informed consent. Polysomnographic studies were performed. Blood was collected to quantify caffeine and its metabolites in plasma and biochemical parameters. 24 h urine samples were collected for catecholamines measurement. Statistical analyses were performed by SPSS: (1) non-parametric Mann-Whitney test to compare variables between controls and OSA; (2) multivariate logistic regression testing the effect of caffeine on sets of variables in the 2 groups; and (3) Spearmans’ correlation between caffeine levels and comorbidities in patients with OSA. As expected OSA development is associated with dyslipidemia, dysmetabolism, SNS dysfunction, and sleep fragmentation. There was also a significant increase in plasma caffeine levels in the OSA group. However, the higher consumption of caffeine by OSA patients do not alter any of these associations. These results showed that there is no apparent rationale for caffeine avoidance in chronic consumers with OSA.application/pdfenDysmetabolism and Sleep Fragmentation in Obstructive Sleep Apnea Patients Run Independently of High Caffeine ConsumptionConde, Sílvia V.PersonalV Conde, SilviaDSpacehttp://dspace.org/items/898e99d8-61a5-44bc-878a-5e1ac44ca37cDSpacehttp://dspace.org/items/898e99d8-61a5-44bc-878a-5e1ac44ca37cVilares CondeSilviaCiência IDhttps://www.ciencia-id.pt561E-CF29-600AORCIDhttp://orcid.org0000-0002-5920-5700Scopus Author IDhttps://www.scopus.com7004283202Scopus Author IDhttps://www.scopus.com7004283202Martins, Fátima O.Dias, Sara S.Pinto, PaulaBárbara, CristinaMonteiro, Emília C.PersonalMonteiro, E.C.DSpacehttp://dspace.org/items/631292a4-58bc-4ec4-97ee-1143e44df2c0DSpacehttp://dspace.org/items/631292a4-58bc-4ec4-97ee-1143e44df2c0MonteiroEmília CarreiraCiência IDhttps://www.ciencia-id.pt5918-54A6-FAA0ORCIDhttp://orcid.org0000-0002-0570-0765Scopus Author IDhttps://www.scopus.com7102113853NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)MDPI AGHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.ptISSNIsPartOf1422-8599URNIsPartOfPURE: 43040438URNIsPartOfPURE UUID: f7b25912-fb83-450f-92c1-b24d5352a457URNIsPartOfScopus: 85127047215URNIsPartOfORCID: /0000-0002-5920-5700/work/111177791URNIsPartOfPubMed: 35405995URNIsPartOfWOS: 000782228700001DOIIsPartOf10.3390/nu140713822022-04-08T22:36:03Z2022-04-012022-04-01T00:00:00ZHandlehttp://hdl.handle.net/10362/136120http://purl.org/coar/access_right/c_abf2open accessapnea/hipopnea indexcaffeinedysmetabolismobstructive sleep apneasleep architecture catecholaminesFood ScienceNutrition and Dietetics286781 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/f71f1c2a-050e-4614-97d6-90d605ad3a80/download |
| spellingShingle | Dysmetabolism and Sleep Fragmentation in Obstructive Sleep Apnea Patients Run Independently of High Caffeine Consumption Conde, Sílvia V. apnea/hipopnea index caffeine dysmetabolism obstructive sleep apnea sleep architecture catecholamines Food Science Nutrition and Dietetics |
| status | SINGLETON |
| subject.fl_str_mv | apnea/hipopnea index caffeine dysmetabolism obstructive sleep apnea sleep architecture catecholamines Food Science Nutrition and Dietetics |
| title | Dysmetabolism and Sleep Fragmentation in Obstructive Sleep Apnea Patients Run Independently of High Caffeine Consumption |
| title_full | Dysmetabolism and Sleep Fragmentation in Obstructive Sleep Apnea Patients Run Independently of High Caffeine Consumption |
| title_fullStr | Dysmetabolism and Sleep Fragmentation in Obstructive Sleep Apnea Patients Run Independently of High Caffeine Consumption |
| title_full_unstemmed | Dysmetabolism and Sleep Fragmentation in Obstructive Sleep Apnea Patients Run Independently of High Caffeine Consumption |
| title_short | Dysmetabolism and Sleep Fragmentation in Obstructive Sleep Apnea Patients Run Independently of High Caffeine Consumption |
| title_sort | Dysmetabolism and Sleep Fragmentation in Obstructive Sleep Apnea Patients Run Independently of High Caffeine Consumption |
| topic | apnea/hipopnea index caffeine dysmetabolism obstructive sleep apnea sleep architecture catecholamines Food Science Nutrition and Dietetics |
| topic_facet | apnea/hipopnea index caffeine dysmetabolism obstructive sleep apnea sleep architecture catecholamines Food Science Nutrition and Dietetics |
| url | http://hdl.handle.net/10362/136120 |
| visible | 1 |