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Unravelling the molecular determinants underlying pH effects on BLG using molecular simulation

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Detalhes bibliográficos
Resumo:"The most abundant protein in bovine milk whey is b-lactoglobulin (BLG), and is known to cause an allergic reaction in susceptible individuals. Although its allergenicity is not fully understood, it has been suggested that it may be related to its dimeric form, as BLG exhibits a pH-dependent monomer-dimer equilibrium. Furthermore, BLG can bind to various ligands through a pH-regulated mechanism, indicating not only a possible biological role as a transporter but also the potential to be exploited as a carrier of bioactive compounds. Although this protein has been widely studied using various experimental techniques, it is still lacking a molecular characterization and a deeper understanding.(...)"
Autores principais:Da Rocha, Lucie
Assunto:computational approach constant-pH molecular method dimerization
Ano:2024
País:Portugal
Tipo de documento:tese de doutoramento
Tipo de acesso:acesso aberto
Instituição associada:Universidade Nova de Lisboa
Idioma:inglês
Origem:Repositório Institucional da UNL

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