Publicação
A homocisteinemia como factor de risco de doença cerebrovascular precoce
| Resumo: | PURPOSE: To determine whether hyperhomocysteinemia represents a risk factor of early thrombotic cerebrovascular disease. METHOD: In a group of patients under 55 years of age (n = 33, 19 males) which had suffered a stroke from 3 months to 1 year before the study, defined by clinical criteria and presence of cerebral infarction confirmed by tomography, without history or predisposition to embolic disease. The patients were matched with a group of normal controls of checkup program, in terms of age, and sex. Patients and controls with a history of alcoholism, clinical or laboratory signs of renal or hepatic insufficiency or with a history of recent ingestion of Group B vitamins were excluded since these conditions would influence homocysteinemia levels. We measured the plasmatic basal homocysteinemia of patients and controls (HC) and 6 hours later a methionine overload of 0.1 g/Kg body weight (LOAD HC). RESULTS: Patients; Controls; Signific.; Age 46.0 +/- 7.7; 45.9 +/- 7.8; NS; Basal HC. 10.1 +/- 3.4; 8.5 +/- 1.7; p < 0.05; Load HC 28.0 +/- 7.6; 22.7 +/- 5.5; p < 0.01. CONCLUSION: In this study hyperhomocysteinemia appears as a risk factor for thrombotic cerebrovascular disease before the age of 55;-The measurement of homocysteinemia after the methionine loading test was more discriminative than the basal measurement;-A larger number of patients and controls will be necessary to establish the relative importance of homocysteinemia among other vascular risk factors in cerebrovascular disease. |
|---|---|
| Autores principais: | Palma dos Reis, Roberto |
| Outros Autores: | Azinheira, J.; Reis, H. P.; Pereira, M.; Baptista, A.; Crespo, M.; Esperança Pina, José; Ferreira, N. C.; Luís, A. S. |
| Assunto: | General Medicine SDG 3 - Good Health and Well-being |
| Ano: | 1994 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | português |
| Origem: | Repositório Institucional da UNL |
| _version_ | 1868983856558768128 |
|---|---|
| author | Palma dos Reis, Roberto |
| author2 | Azinheira, J. Reis, H. P. Pereira, M. Baptista, A. Crespo, M. Esperança Pina, José Ferreira, N. C. Luís, A. S. |
| author2_role | author author author author author author author author |
| author_facet | Palma dos Reis, Roberto Azinheira, J. Reis, H. P. Pereira, M. Baptista, A. Crespo, M. Esperança Pina, José Ferreira, N. C. Luís, A. S. |
| author_role | author |
| contributor_name_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Biblioteca Nacional de Portugal, Centro de Estudos Históricos, CELOM RUN |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Palma dos Reis, Roberto\"},{\"Person.name\":\"Azinheira, J.\"},{\"Person.name\":\"Reis, H. P.\"},{\"Person.name\":\"Pereira, M.\"},{\"Person.name\":\"Baptista, A.\"},{\"Person.name\":\"Crespo, M.\"},{\"Person.name\":\"Esperança Pina, José\"},{\"Person.name\":\"Ferreira, N. C.\"},{\"Person.name\":\"Luís, A. S.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Biblioteca Nacional de Portugal, Centro de Estudos Históricos, CELOM RUN |
| datacite.creators.creator.creatorName.fl_str_mv | Palma dos Reis, Roberto Azinheira, J. Reis, H. P. Pereira, M. Baptista, A. Crespo, M. Esperança Pina, José Ferreira, N. C. Luís, A. S. |
| datacite.date.Accepted.fl_str_mv | 1994-05-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2023-01-16T22:11:27Z |
| datacite.date.embargoed.fl_str_mv | 2023-01-16T22:11:27Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | General Medicine SDG 3 - Good Health and Well-being |
| datacite.titles.title.fl_str_mv | A homocisteinemia como factor de risco de doença cerebrovascular precoce Homocysteinemia as a risk factor in early cerebrovascular disease |
| dc.contributor.none.fl_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Biblioteca Nacional de Portugal, Centro de Estudos Históricos, CELOM RUN |
| dc.creator.none.fl_str_mv | Palma dos Reis, Roberto Azinheira, J. Reis, H. P. Pereira, M. Baptista, A. Crespo, M. Esperança Pina, José Ferreira, N. C. Luís, A. S. |
| dc.date.Accepted.fl_str_mv | 1994-05-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2023-01-16T22:11:27Z |
| dc.date.embargoed.fl_str_mv | 2023-01-16T22:11:27Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10362/147661 |
| dc.language.none.fl_str_mv | por |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | General Medicine SDG 3 - Good Health and Well-being |
| dc.title.fl_str_mv | A homocisteinemia como factor de risco de doença cerebrovascular precoce Homocysteinemia as a risk factor in early cerebrovascular disease |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | PURPOSE: To determine whether hyperhomocysteinemia represents a risk factor of early thrombotic cerebrovascular disease. METHOD: In a group of patients under 55 years of age (n = 33, 19 males) which had suffered a stroke from 3 months to 1 year before the study, defined by clinical criteria and presence of cerebral infarction confirmed by tomography, without history or predisposition to embolic disease. The patients were matched with a group of normal controls of checkup program, in terms of age, and sex. Patients and controls with a history of alcoholism, clinical or laboratory signs of renal or hepatic insufficiency or with a history of recent ingestion of Group B vitamins were excluded since these conditions would influence homocysteinemia levels. We measured the plasmatic basal homocysteinemia of patients and controls (HC) and 6 hours later a methionine overload of 0.1 g/Kg body weight (LOAD HC). RESULTS: Patients; Controls; Signific.; Age 46.0 +/- 7.7; 45.9 +/- 7.8; NS; Basal HC. 10.1 +/- 3.4; 8.5 +/- 1.7; p < 0.05; Load HC 28.0 +/- 7.6; 22.7 +/- 5.5; p < 0.01. CONCLUSION: In this study hyperhomocysteinemia appears as a risk factor for thrombotic cerebrovascular disease before the age of 55;-The measurement of homocysteinemia after the methionine loading test was more discriminative than the basal measurement;-A larger number of patients and controls will be necessary to establish the relative importance of homocysteinemia among other vascular risk factors in cerebrovascular disease. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://run.unl.pt/bitstreams/5b4d45c2-3d96-4401-b59f-4c60456879ab/download |
| id | run_3aa2ea71be586c65d7a4dde48cfa69f7 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10362/147661 |
| inst_facet_str | urn:organizationAcronym:unl{{{_:::_}}}Universidade Nova de Lisboa |
| instacron_str | unl |
| institution | Universidade Nova de Lisboa |
| instname_str | Universidade Nova de Lisboa |
| language | por |
| network_acronym_str | run |
| network_name_str | Repositório Institucional da UNL |
| oai_identifier_str | oai:run.unl.pt:10362/147661 |
| organization_str_mv | urn:organizationAcronym:unl |
| person_str_mv | Palma dos Reis, Roberto Azinheira, J. Reis, H. P. Pereira, M. Baptista, A. Crespo, M. Esperança Pina, José Ferreira, N. C. Luís, A. S. |
| publishDate | 1994 |
| repo_facet_str | urn:repositoryAcronym:run{{{_:::_}}}Repositório Institucional da UNL |
| reponame_str | Repositório Institucional da UNL |
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| spelling | porenPURPOSE: To determine whether hyperhomocysteinemia represents a risk factor of early thrombotic cerebrovascular disease. METHOD: In a group of patients under 55 years of age (n = 33, 19 males) which had suffered a stroke from 3 months to 1 year before the study, defined by clinical criteria and presence of cerebral infarction confirmed by tomography, without history or predisposition to embolic disease. The patients were matched with a group of normal controls of checkup program, in terms of age, and sex. Patients and controls with a history of alcoholism, clinical or laboratory signs of renal or hepatic insufficiency or with a history of recent ingestion of Group B vitamins were excluded since these conditions would influence homocysteinemia levels. We measured the plasmatic basal homocysteinemia of patients and controls (HC) and 6 hours later a methionine overload of 0.1 g/Kg body weight (LOAD HC). RESULTS: Patients; Controls; Signific.; Age 46.0 +/- 7.7; 45.9 +/- 7.8; NS; Basal HC. 10.1 +/- 3.4; 8.5 +/- 1.7; p < 0.05; Load HC 28.0 +/- 7.6; 22.7 +/- 5.5; p < 0.01. CONCLUSION: In this study hyperhomocysteinemia appears as a risk factor for thrombotic cerebrovascular disease before the age of 55;-The measurement of homocysteinemia after the methionine loading test was more discriminative than the basal measurement;-A larger number of patients and controls will be necessary to establish the relative importance of homocysteinemia among other vascular risk factors in cerebrovascular disease.application/pdfptA homocisteinemia como factor de risco de doença cerebrovascular precoceAlternativeTitleenHomocysteinemia as a risk factor in early cerebrovascular diseasePalma dos Reis, RobertoAzinheira, J.Reis, H. P.Pereira, M.Baptista, A.Crespo, M.Esperança Pina, JoséFerreira, N. C.Luís, A. S.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Biblioteca Nacional de Portugal, Centro de Estudos Históricos, CELOMHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.ptISSNIsPartOf0870-399XURNIsPartOfPURE: 10537760URNIsPartOfPURE UUID: 03c56aa8-7bad-4a5b-a9d9-11e3f307c227URNIsPartOfScopus: 0028435344URNIsPartOfPubMed: 80739032023-01-16T22:11:27Z1994-05-011994-05-01T00:00:00ZHandlehttp://hdl.handle.net/10362/147661http://purl.org/coar/access_right/c_abf2open accessGeneral MedicineSDG 3 - Good Health and Well-being397894 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/5b4d45c2-3d96-4401-b59f-4c60456879ab/download |
| spellingShingle | A homocisteinemia como factor de risco de doença cerebrovascular precoce Palma dos Reis, Roberto General Medicine SDG 3 - Good Health and Well-being |
| status | SINGLETON |
| subject.fl_str_mv | General Medicine SDG 3 - Good Health and Well-being |
| title | A homocisteinemia como factor de risco de doença cerebrovascular precoce |
| title_full | A homocisteinemia como factor de risco de doença cerebrovascular precoce |
| title_fullStr | A homocisteinemia como factor de risco de doença cerebrovascular precoce |
| title_full_unstemmed | A homocisteinemia como factor de risco de doença cerebrovascular precoce |
| title_short | A homocisteinemia como factor de risco de doença cerebrovascular precoce |
| title_sort | A homocisteinemia como factor de risco de doença cerebrovascular precoce |
| topic | General Medicine SDG 3 - Good Health and Well-being |
| topic_facet | General Medicine SDG 3 - Good Health and Well-being |
| url | http://hdl.handle.net/10362/147661 |
| visible | 1 |