Publicação
How Biological Activity in Sea Cucumbers Changes as a Function of Species and Tissue
| Resumo: | Biological activity and bioactive compound content in sea cucumbers was assessed, considering Parastichopus regalis, Holothuria mammata, Holothuria forskali, and Holothuria arguinensis as species and intestine, muscle band, respiratory tree, body wall, and gonads as tissues. P. regalis had the lowest content in phenolic compounds and antioxidant activity in contrast to Holothuria species. In the respiratory tree, the highest phenolic concentration was recorded in H. arguinensis, 76.4 ± 1.2 mg GAE/100 g dw vs. 21.0–49.0 mg GAE/100 g dw in the other species. H. arguinensis had the highest DPPH and FRAP results in the gonads, 13.6 ± 0.7 mg AAE/100 g dw vs. 2.6–3.5 mg AAE/100 g dw and 27.1 ± 0.3 μmol Fe2+/g dw vs. 8.0–15.9 μmol Fe2+/g dw, respectively. Overall, P. regalis biomass presented the highest anti-inflammatory activity levels and H. arguinensis the lowest anti-inflammatory levels. The respiratory tree was the most anti-inflammatory (measured by the inhibition of cyclooxygenase-2, COX-2) tissue in H. mammata and H. forskali (also the muscle band in this case), 76.3 ± 6.3% and 59.5 ± 3.6% COX-2 inhibition in 1 mg/mL aqueous extracts, respectively. The results demonstrated a variable bioactive potential and advantage in targeting antioxidant properties in the muscle band and anti-inflammatory activity in the respiratory tree, which may constitute a starting point for a biorefinery approach envisaging multiple applications. |
|---|---|
| Autores principais: | Sales, Sabrina |
| Outros Autores: | Lourenço, Helena M.; Bandarra, Narcisa M.; Afonso, Cláudia; Matos, Joana; Botelho, Maria João; Pessoa, Maria Fernanda; Félix, Pedro M.; Veronez, Arthur; Cardoso, Carlos |
| Assunto: | anti-inflammatory antioxidant aqueous extracts bioactive content holothurians Food Science Microbiology Health(social science) Health Professions (miscellaneous) Plant Science |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| _version_ | 1868415463342473216 |
|---|---|
| author | Sales, Sabrina |
| author2 | Lourenço, Helena M. Bandarra, Narcisa M. Afonso, Cláudia Matos, Joana Botelho, Maria João Pessoa, Maria Fernanda Félix, Pedro M. Veronez, Arthur Cardoso, Carlos |
| author2_role | author author author author author author author author author |
| author_facet | Sales, Sabrina Lourenço, Helena M. Bandarra, Narcisa M. Afonso, Cláudia Matos, Joana Botelho, Maria João Pessoa, Maria Fernanda Félix, Pedro M. Veronez, Arthur Cardoso, Carlos |
| author_role | author |
| contributor_name_str_mv | GeoBioTec - Geobiociências, Geoengenharias e Geotecnologias MDPI - Multidisciplinary Digital Publishing Institute RUN |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Sales, Sabrina\"},{\"Person.name\":\"Lourenço, Helena M.\"},{\"Person.name\":\"Bandarra, Narcisa M.\"},{\"Person.name\":\"Afonso, Cláudia\"},{\"Person.name\":\"Matos, Joana\"},{\"Person.name\":\"Botelho, Maria João\"},{\"Person.name\":\"Pessoa, Maria Fernanda\"},{\"Person.name\":\"Félix, Pedro M.\"},{\"Person.name\":\"Veronez, Arthur\"},{\"Person.name\":\"Cardoso, Carlos\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | GeoBioTec - Geobiociências, Geoengenharias e Geotecnologias MDPI - Multidisciplinary Digital Publishing Institute RUN |
| datacite.creators.creator.creatorName.fl_str_mv | Sales, Sabrina Lourenço, Helena M. Bandarra, Narcisa M. Afonso, Cláudia Matos, Joana Botelho, Maria João Pessoa, Maria Fernanda Félix, Pedro M. Veronez, Arthur Cardoso, Carlos |
| datacite.date.Accepted.fl_str_mv | 2023-12-21T00:00:00Z |
| datacite.date.available.fl_str_mv | 2024-03-28T23:58:41Z |
| datacite.date.embargoed.fl_str_mv | 2024-03-28T23:58:41Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | anti-inflammatory antioxidant aqueous extracts bioactive content holothurians Food Science Microbiology Health(social science) Health Professions (miscellaneous) Plant Science |
| datacite.titles.title.fl_str_mv | How Biological Activity in Sea Cucumbers Changes as a Function of Species and Tissue |
| dc.contributor.none.fl_str_mv | GeoBioTec - Geobiociências, Geoengenharias e Geotecnologias MDPI - Multidisciplinary Digital Publishing Institute RUN |
| dc.creator.none.fl_str_mv | Sales, Sabrina Lourenço, Helena M. Bandarra, Narcisa M. Afonso, Cláudia Matos, Joana Botelho, Maria João Pessoa, Maria Fernanda Félix, Pedro M. Veronez, Arthur Cardoso, Carlos |
| dc.date.Accepted.fl_str_mv | 2023-12-21T00:00:00Z |
| dc.date.available.fl_str_mv | 2024-03-28T23:58:41Z |
| dc.date.embargoed.fl_str_mv | 2024-03-28T23:58:41Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10362/165594 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | anti-inflammatory antioxidant aqueous extracts bioactive content holothurians Food Science Microbiology Health(social science) Health Professions (miscellaneous) Plant Science |
| dc.title.fl_str_mv | How Biological Activity in Sea Cucumbers Changes as a Function of Species and Tissue |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Biological activity and bioactive compound content in sea cucumbers was assessed, considering Parastichopus regalis, Holothuria mammata, Holothuria forskali, and Holothuria arguinensis as species and intestine, muscle band, respiratory tree, body wall, and gonads as tissues. P. regalis had the lowest content in phenolic compounds and antioxidant activity in contrast to Holothuria species. In the respiratory tree, the highest phenolic concentration was recorded in H. arguinensis, 76.4 ± 1.2 mg GAE/100 g dw vs. 21.0–49.0 mg GAE/100 g dw in the other species. H. arguinensis had the highest DPPH and FRAP results in the gonads, 13.6 ± 0.7 mg AAE/100 g dw vs. 2.6–3.5 mg AAE/100 g dw and 27.1 ± 0.3 μmol Fe2+/g dw vs. 8.0–15.9 μmol Fe2+/g dw, respectively. Overall, P. regalis biomass presented the highest anti-inflammatory activity levels and H. arguinensis the lowest anti-inflammatory levels. The respiratory tree was the most anti-inflammatory (measured by the inhibition of cyclooxygenase-2, COX-2) tissue in H. mammata and H. forskali (also the muscle band in this case), 76.3 ± 6.3% and 59.5 ± 3.6% COX-2 inhibition in 1 mg/mL aqueous extracts, respectively. The results demonstrated a variable bioactive potential and advantage in targeting antioxidant properties in the muscle band and anti-inflammatory activity in the respiratory tree, which may constitute a starting point for a biorefinery approach envisaging multiple applications. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://run.unl.pt/bitstreams/04ee8f60-ce4a-4364-8a84-cf19600d24db/download |
| id | run_3ded0f622770aa3be00cdcbbca38ebfb |
| identifier.url.fl_str_mv | http://hdl.handle.net/10362/165594 |
| instacron_str | unl |
| institution | Universidade Nova de Lisboa |
| instname_str | Universidade Nova de Lisboa |
| language | eng |
| network_acronym_str | run |
| network_name_str | Repositório Institucional da UNL |
| oai_identifier_str | oai:run.unl.pt:10362/165594 |
| organization_str_mv | urn:organizationAcronym:unl |
| person_str_mv | Sales, Sabrina Lourenço, Helena M. Bandarra, Narcisa M. Afonso, Cláudia Matos, Joana Botelho, Maria João Pessoa, Maria Fernanda Félix, Pedro M. Veronez, Arthur Cardoso, Carlos |
| publishDate | 2023 |
| reponame_str | Repositório Institucional da UNL |
| repository_id_str | urn:repositoryAcronym:run |
| service_str_mv | urn:repositoryAcronym:run |
| spelling | engenBiological activity and bioactive compound content in sea cucumbers was assessed, considering Parastichopus regalis, Holothuria mammata, Holothuria forskali, and Holothuria arguinensis as species and intestine, muscle band, respiratory tree, body wall, and gonads as tissues. P. regalis had the lowest content in phenolic compounds and antioxidant activity in contrast to Holothuria species. In the respiratory tree, the highest phenolic concentration was recorded in H. arguinensis, 76.4 ± 1.2 mg GAE/100 g dw vs. 21.0–49.0 mg GAE/100 g dw in the other species. H. arguinensis had the highest DPPH and FRAP results in the gonads, 13.6 ± 0.7 mg AAE/100 g dw vs. 2.6–3.5 mg AAE/100 g dw and 27.1 ± 0.3 μmol Fe2+/g dw vs. 8.0–15.9 μmol Fe2+/g dw, respectively. Overall, P. regalis biomass presented the highest anti-inflammatory activity levels and H. arguinensis the lowest anti-inflammatory levels. The respiratory tree was the most anti-inflammatory (measured by the inhibition of cyclooxygenase-2, COX-2) tissue in H. mammata and H. forskali (also the muscle band in this case), 76.3 ± 6.3% and 59.5 ± 3.6% COX-2 inhibition in 1 mg/mL aqueous extracts, respectively. The results demonstrated a variable bioactive potential and advantage in targeting antioxidant properties in the muscle band and anti-inflammatory activity in the respiratory tree, which may constitute a starting point for a biorefinery approach envisaging multiple applications.application/pdfenHow Biological Activity in Sea Cucumbers Changes as a Function of Species and TissueSales, SabrinaLourenço, Helena M.Bandarra, Narcisa M.Afonso, CláudiaMatos, JoanaBotelho, Maria JoãoPessoa, Maria FernandaFélix, Pedro M.Veronez, ArthurCardoso, CarlosGeoBioTec - Geobiociências, Geoengenharias e GeotecnologiasMDPI - Multidisciplinary Digital Publishing InstituteHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.ptISSNIsPartOf2304-8158URNIsPartOfPURE: 86714367URNIsPartOfPURE UUID: 33707c83-147c-46b9-9d25-0f7e917ff41cURNIsPartOfScopus: 85181933337URNIsPartOfWOS: 001139329400001URNIsPartOfPubMed: 38201062URNIsPartOfPubMedCentral: PMC10778530URNIsPartOfORCID: /0000-0002-9352-9776/work/156523235DOIIsPartOf10.3390/foods130100352024-03-28T23:58:41Z2023-12-212023-12-21T00:00:00ZHandlehttp://hdl.handle.net/10362/165594http://purl.org/coar/access_right/c_abf2open accessanti-inflammatoryantioxidantaqueous extractsbioactive contentholothuriansFood ScienceMicrobiologyHealth(social science)Health Professions (miscellaneous)Plant Science609214 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/04ee8f60-ce4a-4364-8a84-cf19600d24db/download |
| spellingShingle | How Biological Activity in Sea Cucumbers Changes as a Function of Species and Tissue Sales, Sabrina anti-inflammatory antioxidant aqueous extracts bioactive content holothurians Food Science Microbiology Health(social science) Health Professions (miscellaneous) Plant Science |
| status | SINGLETON |
| subject.fl_str_mv | anti-inflammatory antioxidant aqueous extracts bioactive content holothurians Food Science Microbiology Health(social science) Health Professions (miscellaneous) Plant Science |
| title | How Biological Activity in Sea Cucumbers Changes as a Function of Species and Tissue |
| title_full | How Biological Activity in Sea Cucumbers Changes as a Function of Species and Tissue |
| title_fullStr | How Biological Activity in Sea Cucumbers Changes as a Function of Species and Tissue |
| title_full_unstemmed | How Biological Activity in Sea Cucumbers Changes as a Function of Species and Tissue |
| title_short | How Biological Activity in Sea Cucumbers Changes as a Function of Species and Tissue |
| title_sort | How Biological Activity in Sea Cucumbers Changes as a Function of Species and Tissue |
| topic | anti-inflammatory antioxidant aqueous extracts bioactive content holothurians Food Science Microbiology Health(social science) Health Professions (miscellaneous) Plant Science |
| topic_facet | anti-inflammatory antioxidant aqueous extracts bioactive content holothurians Food Science Microbiology Health(social science) Health Professions (miscellaneous) Plant Science |
| url | http://hdl.handle.net/10362/165594 |
| visible | 1 |