Publicação
Precision detection of cyanide, fluoride, and hydroxide ions using a new tetraseleno-BODIPY fluorescent sensor
| Resumo: | A new chemosensor based on Seleno-BODIPY (4) was designed and synthesized for the rapid and sensitive detection of CN–, F−, and OH– ions in THF, exhibiting ultra-low detection limits of 26.26 nM, 43.05 nM, and 8.64 nM, respectively, through a turn-on fluorescent process. The seleno-funcionalization step was based on a novel methodology developed by our group, allowing direct functionalization of the BODIPY core. This procedure involves a quick reaction utilizing Ph2Se2 as a selenium source, BPO (benzoyl peroxide), and p-TSA (p-toluenesulfonic acid) in acetonitrile, enabling the production of the corresponding chalcogenated BODIPYs containing one to four selenium groups, demonstrating its versatility. The structure of BODIPY 4 was confirmed by HRMS, 1H, 13C, 77Se NMR, and IR spectra, and its photophysical properties were also evaluated. BODIPY 4 was applied to detect CN–, F−, and OH– ions in dual-mode detection (UV–Vis and fluorescence spectra), displaying a ratiometric response. The new probe exhibited a fast response time, visual color change from blue to fluorescent yellow, and high sensitivity and selectivity for these analytes over other selected anions. Mechanistic investigation through mass analysis revealed that the detection of these anions by BODIPY 4 occurs via an Aromatic Nucleophilic Substitution reaction with phenylselenide as the leaving group. |
|---|---|
| Autores principais: | Cugnasca, Beatriz S. |
| Outros Autores: | Duarte, Frederico; Petrarca de Albuquerque, João L.; Santos, Hugo M.; Luis Capelo-Martínez, José; Lodeiro, Carlos; Dos Santos, Alcindo A. |
| Assunto: | BODIPY Chemosensor Cyanide Fluorescence probe Fluoride Selenium General Chemistry General Chemical Engineering General Physics and Astronomy SDG 3 - Good Health and Well-being |
| Ano: | 2024 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| _version_ | 1868983161536380928 |
|---|---|
| author | Cugnasca, Beatriz S. |
| author2 | Duarte, Frederico Petrarca de Albuquerque, João L. Santos, Hugo M. Luis Capelo-Martínez, José Lodeiro, Carlos Dos Santos, Alcindo A. |
| author2_role | author author author author author author |
| author_facet | Cugnasca, Beatriz S. Duarte, Frederico Petrarca de Albuquerque, João L. Santos, Hugo M. Luis Capelo-Martínez, José Lodeiro, Carlos Dos Santos, Alcindo A. |
| author_role | author |
| contributor_name_str_mv | Faculdade de Ciências e Tecnologia (FCT) LAQV@REQUIMTE DQ - Departamento de Química Elsevier RUN |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Cugnasca, Beatriz S.\"},{\"Person.name\":\"Duarte, Frederico\"},{\"Person.name\":\"Petrarca de Albuquerque, João L.\"},{\"Person.name\":\"Santos, Hugo M.\"},{\"Person.name\":\"Luis Capelo-Martínez, José\"},{\"Person.name\":\"Lodeiro, Carlos\"},{\"Person.name\":\"Dos Santos, Alcindo A.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Faculdade de Ciências e Tecnologia (FCT) LAQV@REQUIMTE DQ - Departamento de Química Elsevier RUN |
| datacite.creators.creator.creatorName.fl_str_mv | Cugnasca, Beatriz S. Duarte, Frederico Petrarca de Albuquerque, João L. Santos, Hugo M. Luis Capelo-Martínez, José Lodeiro, Carlos Dos Santos, Alcindo A. |
| datacite.date.Accepted.fl_str_mv | 2024-12-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2025-02-06T21:16:49Z |
| datacite.date.embargoed.fl_str_mv | 2025-02-06T21:16:49Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | BODIPY Chemosensor Cyanide Fluorescence probe Fluoride Selenium General Chemistry General Chemical Engineering General Physics and Astronomy SDG 3 - Good Health and Well-being |
| datacite.titles.title.fl_str_mv | Precision detection of cyanide, fluoride, and hydroxide ions using a new tetraseleno-BODIPY fluorescent sensor |
| dc.contributor.none.fl_str_mv | Faculdade de Ciências e Tecnologia (FCT) LAQV@REQUIMTE DQ - Departamento de Química Elsevier RUN |
| dc.creator.none.fl_str_mv | Cugnasca, Beatriz S. Duarte, Frederico Petrarca de Albuquerque, João L. Santos, Hugo M. Luis Capelo-Martínez, José Lodeiro, Carlos Dos Santos, Alcindo A. |
| dc.date.Accepted.fl_str_mv | 2024-12-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2025-02-06T21:16:49Z |
| dc.date.embargoed.fl_str_mv | 2025-02-06T21:16:49Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10362/178548 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | BODIPY Chemosensor Cyanide Fluorescence probe Fluoride Selenium General Chemistry General Chemical Engineering General Physics and Astronomy SDG 3 - Good Health and Well-being |
| dc.title.fl_str_mv | Precision detection of cyanide, fluoride, and hydroxide ions using a new tetraseleno-BODIPY fluorescent sensor |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | A new chemosensor based on Seleno-BODIPY (4) was designed and synthesized for the rapid and sensitive detection of CN–, F−, and OH– ions in THF, exhibiting ultra-low detection limits of 26.26 nM, 43.05 nM, and 8.64 nM, respectively, through a turn-on fluorescent process. The seleno-funcionalization step was based on a novel methodology developed by our group, allowing direct functionalization of the BODIPY core. This procedure involves a quick reaction utilizing Ph2Se2 as a selenium source, BPO (benzoyl peroxide), and p-TSA (p-toluenesulfonic acid) in acetonitrile, enabling the production of the corresponding chalcogenated BODIPYs containing one to four selenium groups, demonstrating its versatility. The structure of BODIPY 4 was confirmed by HRMS, 1H, 13C, 77Se NMR, and IR spectra, and its photophysical properties were also evaluated. BODIPY 4 was applied to detect CN–, F−, and OH– ions in dual-mode detection (UV–Vis and fluorescence spectra), displaying a ratiometric response. The new probe exhibited a fast response time, visual color change from blue to fluorescent yellow, and high sensitivity and selectivity for these analytes over other selected anions. Mechanistic investigation through mass analysis revealed that the detection of these anions by BODIPY 4 occurs via an Aromatic Nucleophilic Substitution reaction with phenylselenide as the leaving group. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://run.unl.pt/bitstreams/a9aeca9d-5c46-43d9-8e67-6b31541f97bd/download |
| id | run_3fc925afa0e7db92fe421aa8d8079e7e |
| identifier.url.fl_str_mv | http://hdl.handle.net/10362/178548 |
| inst_facet_str | urn:organizationAcronym:unl{{{_:::_}}}Universidade Nova de Lisboa |
| instacron_str | unl |
| institution | Universidade Nova de Lisboa |
| instname_str | Universidade Nova de Lisboa |
| language | eng |
| network_acronym_str | run |
| network_name_str | Repositório Institucional da UNL |
| oai_identifier_str | oai:run.unl.pt:10362/178548 |
| organization_str_mv | urn:organizationAcronym:unl |
| person_str_mv | Cugnasca, Beatriz S. Duarte, Frederico Petrarca de Albuquerque, João L. Santos, Hugo M. Luis Capelo-Martínez, José Lodeiro, Carlos Dos Santos, Alcindo A. |
| publishDate | 2024 |
| repo_facet_str | urn:repositoryAcronym:run{{{_:::_}}}Repositório Institucional da UNL |
| reponame_str | Repositório Institucional da UNL |
| repository_id_str | urn:repositoryAcronym:run |
| service_str_mv | urn:repositoryAcronym:run |
| spelling | engenA new chemosensor based on Seleno-BODIPY (4) was designed and synthesized for the rapid and sensitive detection of CN–, F−, and OH– ions in THF, exhibiting ultra-low detection limits of 26.26 nM, 43.05 nM, and 8.64 nM, respectively, through a turn-on fluorescent process. The seleno-funcionalization step was based on a novel methodology developed by our group, allowing direct functionalization of the BODIPY core. This procedure involves a quick reaction utilizing Ph2Se2 as a selenium source, BPO (benzoyl peroxide), and p-TSA (p-toluenesulfonic acid) in acetonitrile, enabling the production of the corresponding chalcogenated BODIPYs containing one to four selenium groups, demonstrating its versatility. The structure of BODIPY 4 was confirmed by HRMS, 1H, 13C, 77Se NMR, and IR spectra, and its photophysical properties were also evaluated. BODIPY 4 was applied to detect CN–, F−, and OH– ions in dual-mode detection (UV–Vis and fluorescence spectra), displaying a ratiometric response. The new probe exhibited a fast response time, visual color change from blue to fluorescent yellow, and high sensitivity and selectivity for these analytes over other selected anions. Mechanistic investigation through mass analysis revealed that the detection of these anions by BODIPY 4 occurs via an Aromatic Nucleophilic Substitution reaction with phenylselenide as the leaving group.application/pdfenPrecision detection of cyanide, fluoride, and hydroxide ions using a new tetraseleno-BODIPY fluorescent sensorCugnasca, Beatriz S.Duarte, FredericoPetrarca de Albuquerque, João L.Santos, Hugo M.Luis Capelo-Martínez, JoséLodeiro, CarlosDos Santos, Alcindo A.Faculdade de Ciências e Tecnologia (FCT)LAQV@REQUIMTEDQ - Departamento de QuímicaElsevierHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.ptISSNIsPartOf1010-6030URNIsPartOfPURE: 98899382URNIsPartOfPURE UUID: 8b1005fa-37b4-42ef-af4f-332c6cee6931URNIsPartOfScopus: 85198091971URNIsPartOfWOS: 001269613700001URNIsPartOfORCID: /0000-0002-6032-8679/work/177535343URNIsPartOfORCID: /0000-0001-5582-5446/work/201987768DOIIsPartOf10.1016/j.jphotochem.2024.1158812025-02-06T21:16:49Z2024-12-012024-12-01T00:00:00ZHandlehttp://hdl.handle.net/10362/178548http://purl.org/coar/access_right/c_abf2open accessBODIPYChemosensorCyanideFluorescence probeFluorideSeleniumGeneral ChemistryGeneral Chemical EngineeringGeneral Physics and AstronomySDG 3 - Good Health and Well-being4530291 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/a9aeca9d-5c46-43d9-8e67-6b31541f97bd/download |
| spellingShingle | Precision detection of cyanide, fluoride, and hydroxide ions using a new tetraseleno-BODIPY fluorescent sensor Cugnasca, Beatriz S. BODIPY Chemosensor Cyanide Fluorescence probe Fluoride Selenium General Chemistry General Chemical Engineering General Physics and Astronomy SDG 3 - Good Health and Well-being |
| status | SINGLETON |
| subject.fl_str_mv | BODIPY Chemosensor Cyanide Fluorescence probe Fluoride Selenium General Chemistry General Chemical Engineering General Physics and Astronomy SDG 3 - Good Health and Well-being |
| title | Precision detection of cyanide, fluoride, and hydroxide ions using a new tetraseleno-BODIPY fluorescent sensor |
| title_full | Precision detection of cyanide, fluoride, and hydroxide ions using a new tetraseleno-BODIPY fluorescent sensor |
| title_fullStr | Precision detection of cyanide, fluoride, and hydroxide ions using a new tetraseleno-BODIPY fluorescent sensor |
| title_full_unstemmed | Precision detection of cyanide, fluoride, and hydroxide ions using a new tetraseleno-BODIPY fluorescent sensor |
| title_short | Precision detection of cyanide, fluoride, and hydroxide ions using a new tetraseleno-BODIPY fluorescent sensor |
| title_sort | Precision detection of cyanide, fluoride, and hydroxide ions using a new tetraseleno-BODIPY fluorescent sensor |
| topic | BODIPY Chemosensor Cyanide Fluorescence probe Fluoride Selenium General Chemistry General Chemical Engineering General Physics and Astronomy SDG 3 - Good Health and Well-being |
| topic_facet | BODIPY Chemosensor Cyanide Fluorescence probe Fluoride Selenium General Chemistry General Chemical Engineering General Physics and Astronomy SDG 3 - Good Health and Well-being |
| url | http://hdl.handle.net/10362/178548 |
| visible | 1 |