Publicação
Hyperparathyroidism, Serum Phosphorus and Dietary Intake in Hemodialysis Patients
| Resumo: | The management of hyperparathyroidism (intact parathyroid hormone (iPTH) serum levels > 585 pg/mL), frequently focuses on the appropriate control of mineral and bone markers, with the decrease in serum and dietary phosphorus as two of the targets. We aimed to investigate the association between iPTH, serum phosphorus levels and dietary intake. This was a cross-sectional, multicenter, observational study with 561 patients on hemodialysis treatment. Clinical parameters, body composition and dietary intake were assessed. For the analysis, patients were divided into three groups: (a) iPTH < 130, (b) iPTH between 130 and 585 and (c) iPTH > 585 pg/mL. The association between PTH, serum phosphorus and dietary intake was analyzed using linear regression models. In the whole sample, 23.2% of patients presented an iPTH > 585 pg/mL. Patients with higher iPTH levels were those with longer HD vintage and lower ages, higher serum phosphorus, serum calcium, Ca/P product, albumin and caffeine intake, and a lower dietary intake of phosphorus, fiber, riboflavin and folate. Higher serum phosphorus predicted higher iPTH levels, even in the adjusted model. However, lower dietary phosphorus and fiber intake were predictors of higher iPTH levels, including in the adjusted model. Our results bring new data to the relationship between dietary intake and iPTH values. Despite higher serum phosphorus being observed in patients with HPTH, an opposite association was noted regarding dietary phosphate and fiber. |
|---|---|
| Autores principais: | Garagarza, Cristina |
| Outros Autores: | Valente, Ana; Queirós, Cátia; Neto, Inês Pastor; Sebastião, Joana; Gomes, Melanie; Ferreira, Aníbal |
| Assunto: | dialysis food intake nutritional status parathyroid hormone Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry |
| Ano: | 2024 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| _version_ | 1865920611221504000 |
|---|---|
| author | Garagarza, Cristina |
| author2 | Valente, Ana Queirós, Cátia Neto, Inês Pastor Sebastião, Joana Gomes, Melanie Ferreira, Aníbal |
| author2_role | author author author author author author |
| author_facet | Garagarza, Cristina Garagarza, Cristina Valente, Ana Queirós, Cátia Neto, Inês Pastor Sebastião, Joana Gomes, Melanie Ferreira, Aníbal Valente, Ana Queirós, Cátia Neto, Inês Pastor Sebastião, Joana Gomes, Melanie Ferreira, Aníbal |
| author_role | author |
| contributor_name_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) MDPI - Multidisciplinary Digital Publishing Institute RUN |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Garagarza, Cristina\"},{\"Person.name\":\"Valente, Ana\"},{\"Person.name\":\"Queirós, Cátia\"},{\"Person.name\":\"Neto, Inês Pastor\"},{\"Person.name\":\"Sebastião, Joana\"},{\"Person.name\":\"Gomes, Melanie\"},{\"Person.name\":\"Ferreira, Aníbal\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) MDPI - Multidisciplinary Digital Publishing Institute RUN |
| datacite.creators.creator.creatorName.fl_str_mv | Garagarza, Cristina Valente, Ana Queirós, Cátia Neto, Inês Pastor Sebastião, Joana Gomes, Melanie Ferreira, Aníbal |
| datacite.date.Accepted.fl_str_mv | 2024-02-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2024-03-06T23:52:51Z |
| datacite.date.embargoed.fl_str_mv | 2024-03-06T23:52:51Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | dialysis food intake nutritional status parathyroid hormone Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry |
| datacite.titles.title.fl_str_mv | Hyperparathyroidism, Serum Phosphorus and Dietary Intake in Hemodialysis Patients Is There a Novel Relationship? |
| dc.contributor.none.fl_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) MDPI - Multidisciplinary Digital Publishing Institute RUN |
| dc.creator.none.fl_str_mv | Garagarza, Cristina Valente, Ana Queirós, Cátia Neto, Inês Pastor Sebastião, Joana Gomes, Melanie Ferreira, Aníbal |
| dc.date.Accepted.fl_str_mv | 2024-02-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2024-03-06T23:52:51Z |
| dc.date.embargoed.fl_str_mv | 2024-03-06T23:52:51Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10362/164572 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | dialysis food intake nutritional status parathyroid hormone Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry |
| dc.title.fl_str_mv | Hyperparathyroidism, Serum Phosphorus and Dietary Intake in Hemodialysis Patients Is There a Novel Relationship? |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The management of hyperparathyroidism (intact parathyroid hormone (iPTH) serum levels > 585 pg/mL), frequently focuses on the appropriate control of mineral and bone markers, with the decrease in serum and dietary phosphorus as two of the targets. We aimed to investigate the association between iPTH, serum phosphorus levels and dietary intake. This was a cross-sectional, multicenter, observational study with 561 patients on hemodialysis treatment. Clinical parameters, body composition and dietary intake were assessed. For the analysis, patients were divided into three groups: (a) iPTH < 130, (b) iPTH between 130 and 585 and (c) iPTH > 585 pg/mL. The association between PTH, serum phosphorus and dietary intake was analyzed using linear regression models. In the whole sample, 23.2% of patients presented an iPTH > 585 pg/mL. Patients with higher iPTH levels were those with longer HD vintage and lower ages, higher serum phosphorus, serum calcium, Ca/P product, albumin and caffeine intake, and a lower dietary intake of phosphorus, fiber, riboflavin and folate. Higher serum phosphorus predicted higher iPTH levels, even in the adjusted model. However, lower dietary phosphorus and fiber intake were predictors of higher iPTH levels, including in the adjusted model. Our results bring new data to the relationship between dietary intake and iPTH values. Despite higher serum phosphorus being observed in patients with HPTH, an opposite association was noted regarding dietary phosphate and fiber. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://run.unl.pt/bitstreams/9c7a5d59-c5a2-41bb-9a72-cae0b513c6a1/download |
| id | run_42cce9964447bf8fb3f8fe9f0d18dccb |
| identifier.url.fl_str_mv | http://hdl.handle.net/10362/164572 |
| instacron_str | unl |
| institution | Universidade Nova de Lisboa |
| instname_str | Universidade Nova de Lisboa |
| language | eng |
| network_acronym_str | run |
| network_name_str | Repositório Institucional da UNL |
| oai_identifier_str | oai:run.unl.pt:10362/164572 |
| organization_str_mv | urn:organizationAcronym:unl |
| person_str_mv | Garagarza, Cristina Valente, Ana Queirós, Cátia Neto, Inês Pastor Sebastião, Joana Gomes, Melanie Ferreira, Aníbal |
| publishDate | 2024 |
| reponame_str | Repositório Institucional da UNL |
| repository_id_str | urn:repositoryAcronym:run |
| service_str_mv | urn:repositoryAcronym:run |
| spelling | engenThe management of hyperparathyroidism (intact parathyroid hormone (iPTH) serum levels > 585 pg/mL), frequently focuses on the appropriate control of mineral and bone markers, with the decrease in serum and dietary phosphorus as two of the targets. We aimed to investigate the association between iPTH, serum phosphorus levels and dietary intake. This was a cross-sectional, multicenter, observational study with 561 patients on hemodialysis treatment. Clinical parameters, body composition and dietary intake were assessed. For the analysis, patients were divided into three groups: (a) iPTH < 130, (b) iPTH between 130 and 585 and (c) iPTH > 585 pg/mL. The association between PTH, serum phosphorus and dietary intake was analyzed using linear regression models. In the whole sample, 23.2% of patients presented an iPTH > 585 pg/mL. Patients with higher iPTH levels were those with longer HD vintage and lower ages, higher serum phosphorus, serum calcium, Ca/P product, albumin and caffeine intake, and a lower dietary intake of phosphorus, fiber, riboflavin and folate. Higher serum phosphorus predicted higher iPTH levels, even in the adjusted model. However, lower dietary phosphorus and fiber intake were predictors of higher iPTH levels, including in the adjusted model. Our results bring new data to the relationship between dietary intake and iPTH values. Despite higher serum phosphorus being observed in patients with HPTH, an opposite association was noted regarding dietary phosphate and fiber.application/pdfenHyperparathyroidism, Serum Phosphorus and Dietary Intake in Hemodialysis PatientsSubtitleenIs There a Novel Relationship?Garagarza, CristinaValente, AnaQueirós, CátiaNeto, Inês PastorSebastião, JoanaGomes, MelanieFerreira, AníbalNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)MDPI - Multidisciplinary Digital Publishing InstituteHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.ptISSNIsPartOf1661-6596URNIsPartOfPURE: 84546488URNIsPartOfPURE UUID: 1b35e70e-410e-470f-a3ae-095c84939e3aURNIsPartOfScopus: 85185866299URNIsPartOfPubMed: 38396685DOIIsPartOf10.3390/ijms250420062024-03-06T23:52:51Z2024-022024-02-01T00:00:00ZHandlehttp://hdl.handle.net/10362/164572http://purl.org/coar/access_right/c_abf2open accessdialysisfood intakenutritional statusparathyroid hormoneCatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic Chemistry293528 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/9c7a5d59-c5a2-41bb-9a72-cae0b513c6a1/download |
| spellingShingle | Hyperparathyroidism, Serum Phosphorus and Dietary Intake in Hemodialysis Patients Hyperparathyroidism, Serum Phosphorus and Dietary Intake in Hemodialysis Patients Garagarza, Cristina dialysis food intake nutritional status parathyroid hormone Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry Garagarza, Cristina dialysis food intake nutritional status parathyroid hormone Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry |
| status | NEW |
| subject.fl_str_mv | dialysis food intake nutritional status parathyroid hormone Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry |
| title | Hyperparathyroidism, Serum Phosphorus and Dietary Intake in Hemodialysis Patients |
| title_full | Hyperparathyroidism, Serum Phosphorus and Dietary Intake in Hemodialysis Patients |
| title_fullStr | Hyperparathyroidism, Serum Phosphorus and Dietary Intake in Hemodialysis Patients Hyperparathyroidism, Serum Phosphorus and Dietary Intake in Hemodialysis Patients |
| title_full_unstemmed | Hyperparathyroidism, Serum Phosphorus and Dietary Intake in Hemodialysis Patients Hyperparathyroidism, Serum Phosphorus and Dietary Intake in Hemodialysis Patients |
| title_short | Hyperparathyroidism, Serum Phosphorus and Dietary Intake in Hemodialysis Patients |
| title_sort | Hyperparathyroidism, Serum Phosphorus and Dietary Intake in Hemodialysis Patients |
| topic | dialysis food intake nutritional status parathyroid hormone Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry |
| topic_facet | dialysis food intake nutritional status parathyroid hormone Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry |
| url | http://hdl.handle.net/10362/164572 |
| visible | 1 |