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The role of regulatory CD4+CD25+ T cell subset in host homeostasis during protozoan infection

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Resumo:Human diseases caused by protozoan parasites are renowned for their high rates of morbidity and mortality worldwide. Some examples include African trypanosomiasis or sleeping sickness, American trypanosomiasis or Chagas disease, leishmaniases, malaria and babesiosis. These infections tend to follow a chronic rather than an acute course with lifelong persistence of parasites. Regulatory T cells (Treg), in particular the CD4+CD25+ cell subset, appear to control the immune competence of host response triggered by the presence of parasites, promoting homeostasis and protecting the host from collateral tissue damage whilst allowing parasite persistence. To date, there is still considerable controversy on the characteristics and function of these cells when induced during diferente protozoan infections, evidencing the need of further research. Therefore, this review aims to provide a comprehensive overview about Treg cells development, phenotype determination and general functions. The above pathologies were used as selected examples to discuss the role of Treg cells during protozoan infections. Understanding of the mechanisms that contribute towards homeostasis and the survival of the host, and simultaneously allow the persistence of the pathogen, may yield important insights for new strategies of prophylaxis and therapy .
Autores principais:Ferrolho, Joana
Outros Autores:Domingues, Nuno; Domingos, A; Santos-Gomes, G
Assunto:Protozoan infections Regulatory T cells CD4+CD25+FoxP3+ cell subset Trypanosoma spp. Leishmania spp. Plasmodium spp. Babesia spp. Immunology Parasitology SDG 3 - Good Health and Well-being
Ano:2015
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Universidade Nova de Lisboa
Idioma:inglês
Origem:Repositório Institucional da UNL

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