Publication
Audiological biomarkers of tinnitus in an older Portuguese population
| Summary: | Tinnitus is a phantom sound perceived in the absence of external acoustic stimulation. It is described in a variety of ways (e.g., buzzing, ringing, and roaring) and can be a single sound or a combination of different sounds. Our study evaluated associations between audiological parameters and the presence or severity of tinnitus, to improve tinnitus diagnosis, treatment, and prognosis. Our sample included 122 older participants (63 women and 59 men), aged 55-75 years from the Portuguese population, with or without sensory presbycusis and with or without tinnitus. All participants underwent a clinical evaluation through a structured interview, Ear, Nose, and Throat observation, and audiological evaluation (standard and extended audiometry, psychoacoustic tinnitus evaluation, auditory brainstem responses, and distortion product otoacoustic emissions). The Tinnitus Handicap Inventory was used to measure tinnitus symptom severity. Our data confirmed that the odds of developing tinnitus were significantly higher in the presence of noise exposure and hearing loss. Also, participants who had abrupt tinnitus onset and moderate or severe hyperacusis featured higher odds of at least moderate tinnitus. However, it was in the ABR that we obtained the most exciting and promising results, namely, in wave I, which was the common denominator in all findings. The increase in wave I amplitude is a protective factor to the odds of having tinnitus. Concerning the severity of tinnitus, the logistic regression model showed that for each unit of increase in the mean ratio V/I of ABR, the likelihood of having at least moderate tinnitus was 10% higher. Advancing knowledge concerning potential tinnitus audiological biomarkers can be crucial for the adequate diagnosis and treatment of tinnitus. |
|---|---|
| Main Authors: | Haider, Haúla F |
| Other Authors: | Ribeiro, Diogo; Ribeiro, Sara F; Trigueiros, Nuno; Caria, Helena; Borrego, Luís; BORREGO, LUIS MIGUEL; Pinto, Iola; Papoila, Ana L; Papoila, A.L.; Hoare, Derek J; Paço, João |
| Subject: | audiological biomarkers auditory brainstem response distortion product otoacoustic emissions hearing loss pure tone average tinnitus |
| Year: | 2022 |
| Country: | Portugal |
| Document type: | article |
| Access type: | open access |
| Associated institution: | Universidade Nova de Lisboa |
| Language: | English |
| Origin: | Repositório Institucional da UNL |
| _version_ | 1868982450665816064 |
|---|---|
| author | Haider, Haúla F |
| author2 | Ribeiro, Diogo Ribeiro, Sara F Trigueiros, Nuno Caria, Helena Borrego, Luís BORREGO, LUIS MIGUEL Pinto, Iola Papoila, Ana L Papoila, A.L. Hoare, Derek J Paço, João |
| author2_role | author author author author author author author author author author author |
| author_facet | Haider, Haúla F Ribeiro, Diogo Ribeiro, Sara F Trigueiros, Nuno Caria, Helena Borrego, Luís BORREGO, LUIS MIGUEL Pinto, Iola Papoila, Ana L Papoila, A.L. Hoare, Derek J Paço, João |
| author_role | author |
| contributor_name_str_mv | Comprehensive Health Research Centre (CHRC) - pólo NMS NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) CMA - Centro de Matemática e Aplicações Faculdade de Ciências e Tecnologia (FCT) Frontiers Media RUN |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Haider, Haúla F\"},{\"Person.name\":\"Ribeiro, Diogo\"},{\"Person.name\":\"Ribeiro, Sara F\"},{\"Person.name\":\"Trigueiros, Nuno\"},{\"Person.name\":\"Caria, Helena\"},{\"Person.name\":\"Borrego, Luís\"},{\"Person.name\":\"BORREGO, LUIS MIGUEL\",\"Person.identifier.orcid\":\"0000-0003-4708-438X\"},{\"Person.name\":\"Pinto, Iola\"},{\"Person.name\":\"Papoila, Ana L\"},{\"Person.name\":\"Papoila, A.L.\",\"Person.identifier.orcid\":\"0000-0002-2918-8364\"},{\"Person.name\":\"Hoare, Derek J\"},{\"Person.name\":\"Paço, João\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Comprehensive Health Research Centre (CHRC) - pólo NMS NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) CMA - Centro de Matemática e Aplicações Faculdade de Ciências e Tecnologia (FCT) Frontiers Media RUN |
| datacite.creators.creator.creatorName.fl_str_mv | Haider, Haúla F Ribeiro, Diogo Ribeiro, Sara F Trigueiros, Nuno Caria, Helena Borrego, Luís BORREGO, LUIS MIGUEL Pinto, Iola Papoila, Ana L Papoila, A.L. Hoare, Derek J Paço, João |
| datacite.date.Accepted.fl_str_mv | 2022-08-24T00:00:00Z |
| datacite.date.available.fl_str_mv | 2022-09-22T22:37:16Z |
| datacite.date.embargoed.fl_str_mv | 2022-09-22T22:37:16Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | audiological biomarkers auditory brainstem response distortion product otoacoustic emissions hearing loss pure tone average tinnitus |
| datacite.titles.title.fl_str_mv | Audiological biomarkers of tinnitus in an older Portuguese population |
| dc.contributor.none.fl_str_mv | Comprehensive Health Research Centre (CHRC) - pólo NMS NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) CMA - Centro de Matemática e Aplicações Faculdade de Ciências e Tecnologia (FCT) Frontiers Media RUN |
| dc.creator.none.fl_str_mv | Haider, Haúla F Ribeiro, Diogo Ribeiro, Sara F Trigueiros, Nuno Caria, Helena Borrego, Luís BORREGO, LUIS MIGUEL Pinto, Iola Papoila, Ana L Papoila, A.L. Hoare, Derek J Paço, João |
| dc.date.Accepted.fl_str_mv | 2022-08-24T00:00:00Z |
| dc.date.available.fl_str_mv | 2022-09-22T22:37:16Z |
| dc.date.embargoed.fl_str_mv | 2022-09-22T22:37:16Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10362/143966 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | audiological biomarkers auditory brainstem response distortion product otoacoustic emissions hearing loss pure tone average tinnitus |
| dc.title.fl_str_mv | Audiological biomarkers of tinnitus in an older Portuguese population |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Tinnitus is a phantom sound perceived in the absence of external acoustic stimulation. It is described in a variety of ways (e.g., buzzing, ringing, and roaring) and can be a single sound or a combination of different sounds. Our study evaluated associations between audiological parameters and the presence or severity of tinnitus, to improve tinnitus diagnosis, treatment, and prognosis. Our sample included 122 older participants (63 women and 59 men), aged 55-75 years from the Portuguese population, with or without sensory presbycusis and with or without tinnitus. All participants underwent a clinical evaluation through a structured interview, Ear, Nose, and Throat observation, and audiological evaluation (standard and extended audiometry, psychoacoustic tinnitus evaluation, auditory brainstem responses, and distortion product otoacoustic emissions). The Tinnitus Handicap Inventory was used to measure tinnitus symptom severity. Our data confirmed that the odds of developing tinnitus were significantly higher in the presence of noise exposure and hearing loss. Also, participants who had abrupt tinnitus onset and moderate or severe hyperacusis featured higher odds of at least moderate tinnitus. However, it was in the ABR that we obtained the most exciting and promising results, namely, in wave I, which was the common denominator in all findings. The increase in wave I amplitude is a protective factor to the odds of having tinnitus. Concerning the severity of tinnitus, the logistic regression model showed that for each unit of increase in the mean ratio V/I of ABR, the likelihood of having at least moderate tinnitus was 10% higher. Advancing knowledge concerning potential tinnitus audiological biomarkers can be crucial for the adequate diagnosis and treatment of tinnitus. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://run.unl.pt/bitstreams/b08cee8c-00ba-4149-9704-36935a18abb5/download |
| id | run_509fcc9b6759d2b2bb3501903e79e68d |
| identifier.url.fl_str_mv | http://hdl.handle.net/10362/143966 |
| inst_facet_str | urn:organizationAcronym:unl{{{_:::_}}}Universidade Nova de Lisboa |
| instacron_str | unl |
| institution | Universidade Nova de Lisboa |
| instname_str | Universidade Nova de Lisboa |
| language | eng |
| network_acronym_str | run |
| network_name_str | Repositório Institucional da UNL |
| oai_identifier_str | oai:run.unl.pt:10362/143966 |
| organization_str_mv | urn:organizationAcronym:unl |
| person_str_mv | Haider, Haúla F Ribeiro, Diogo Ribeiro, Sara F Trigueiros, Nuno Caria, Helena Borrego, Luís BORREGO, LUIS MIGUEL BORREGO, LUIS MIGUEL https://www.ciencia-id.pt/4119-915F-EF0F 4119-915F-EF0F http://orcid.org/0000-0003-4708-438X 0000-0003-4708-438X Pinto, Iola Papoila, Ana L Papoila, A.L. Papoila, A.L. https://www.ciencia-id.pt/251C-0273-1068 251C-0273-1068 http://orcid.org/0000-0002-2918-8364 0000-0002-2918-8364 Hoare, Derek J Paço, João |
| publishDate | 2022 |
| repo_facet_str | urn:repositoryAcronym:run{{{_:::_}}}Repositório Institucional da UNL |
| reponame_str | Repositório Institucional da UNL |
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| service_str_mv | urn:repositoryAcronym:run |
| spelling | engenTinnitus is a phantom sound perceived in the absence of external acoustic stimulation. It is described in a variety of ways (e.g., buzzing, ringing, and roaring) and can be a single sound or a combination of different sounds. Our study evaluated associations between audiological parameters and the presence or severity of tinnitus, to improve tinnitus diagnosis, treatment, and prognosis. Our sample included 122 older participants (63 women and 59 men), aged 55-75 years from the Portuguese population, with or without sensory presbycusis and with or without tinnitus. All participants underwent a clinical evaluation through a structured interview, Ear, Nose, and Throat observation, and audiological evaluation (standard and extended audiometry, psychoacoustic tinnitus evaluation, auditory brainstem responses, and distortion product otoacoustic emissions). The Tinnitus Handicap Inventory was used to measure tinnitus symptom severity. Our data confirmed that the odds of developing tinnitus were significantly higher in the presence of noise exposure and hearing loss. Also, participants who had abrupt tinnitus onset and moderate or severe hyperacusis featured higher odds of at least moderate tinnitus. However, it was in the ABR that we obtained the most exciting and promising results, namely, in wave I, which was the common denominator in all findings. The increase in wave I amplitude is a protective factor to the odds of having tinnitus. Concerning the severity of tinnitus, the logistic regression model showed that for each unit of increase in the mean ratio V/I of ABR, the likelihood of having at least moderate tinnitus was 10% higher. Advancing knowledge concerning potential tinnitus audiological biomarkers can be crucial for the adequate diagnosis and treatment of tinnitus.application/pdfenAudiological biomarkers of tinnitus in an older Portuguese populationHaider, Haúla FRibeiro, DiogoRibeiro, Sara FTrigueiros, NunoCaria, HelenaBorrego, LuísPersonalBORREGO, LUIS MIGUELDSpacehttp://dspace.org/items/027a8b74-0ce7-4daa-9ef4-917b9ec6f95aDSpacehttp://dspace.org/items/027a8b74-0ce7-4daa-9ef4-917b9ec6f95aBORREGOLUIS MIGUELCiência IDhttps://www.ciencia-id.pt4119-915F-EF0FORCIDhttp://orcid.org0000-0003-4708-438XScopus Author IDhttps://www.scopus.com8346933500Pinto, IolaPapoila, Ana LPersonalPapoila, A.L.DSpacehttp://dspace.org/items/5ce1bd05-e7a4-4bd0-9527-f511c0889095DSpacehttp://dspace.org/items/5ce1bd05-e7a4-4bd0-9527-f511c0889095PapoilaAna LuisaCiência IDhttps://www.ciencia-id.pt251C-0273-1068ORCIDhttp://orcid.org0000-0002-2918-8364Researcher IDhttps://www.researcherid.comS-2515-2016Scopus Author IDhttps://www.scopus.com6507532321Hoare, Derek JPaço, JoãoComprehensive Health Research Centre (CHRC) - pólo NMSNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)CMA - Centro de Matemática e AplicaçõesFaculdade de Ciências e Tecnologia (FCT)Frontiers MediaHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.ptISSNIsPartOf1663-4365URNIsPartOfPURE: 46535406URNIsPartOfPURE UUID: 3f4e4f9c-c57e-45fa-a46a-f06093432089URNIsPartOfPubMed: 36092804URNIsPartOfPubMedCentral: PMC9449802URNIsPartOfORCID: /0000-0003-4708-438X/work/119521916URNIsPartOfScopus: 85138071674URNIsPartOfWOS: 000850811400001DOIIsPartOf10.3389/fnagi.2022.9331172022-09-22T22:37:16Z2022-08-242022-08-24T00:00:00ZHandlehttp://hdl.handle.net/10362/143966http://purl.org/coar/access_right/c_abf2open accessaudiological biomarkersauditory brainstem responsedistortion product otoacoustic emissionshearing losspure tone averagetinnitus1731519 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/b08cee8c-00ba-4149-9704-36935a18abb5/download |
| spellingShingle | Audiological biomarkers of tinnitus in an older Portuguese population Haider, Haúla F audiological biomarkers auditory brainstem response distortion product otoacoustic emissions hearing loss pure tone average tinnitus |
| status | SINGLETON |
| subject.fl_str_mv | audiological biomarkers auditory brainstem response distortion product otoacoustic emissions hearing loss pure tone average tinnitus |
| title | Audiological biomarkers of tinnitus in an older Portuguese population |
| title_full | Audiological biomarkers of tinnitus in an older Portuguese population |
| title_fullStr | Audiological biomarkers of tinnitus in an older Portuguese population |
| title_full_unstemmed | Audiological biomarkers of tinnitus in an older Portuguese population |
| title_short | Audiological biomarkers of tinnitus in an older Portuguese population |
| title_sort | Audiological biomarkers of tinnitus in an older Portuguese population |
| topic | audiological biomarkers auditory brainstem response distortion product otoacoustic emissions hearing loss pure tone average tinnitus |
| topic_facet | audiological biomarkers auditory brainstem response distortion product otoacoustic emissions hearing loss pure tone average tinnitus |
| url | http://hdl.handle.net/10362/143966 |
| visible | 1 |