Publicação
Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention
| Resumo: | Background: Individuals with pre-diabetes are commonly overweight and benefit from dietary and physical activity strategies aimed at decreasing body weight and hyperglycemia. Early insulin resistance can be estimated via the triglyceride glucose index {TyG = Ln [TG (mg/dl) × fasting plasma glucose (FPG) (mg/dl)/2]} and the hypertriglyceridemic-high waist phenotype (TyG-waist), based on TyG x waist circumference (WC) measurements. Both indices may be useful for implementing personalized metabolic management. In this secondary analysis of a randomized controlled trial (RCT), we aimed to determine whether the differences in baseline TyG values and TyG-waist phenotype predicted individual responses to type-2 diabetes (T2D) prevention programs. Methods: The present post-hoc analyses were conducted within the Prevention of Diabetes through Lifestyle intervention and population studies in Europe and around the world (PREVIEW) study completers (n = 899), a multi-center RCT conducted in eight countries (NCT01777893). The study aimed to reduce the incidence of T2D in a population with pre-diabetes during a 3-year randomized intervention with two sequential phases. The first phase was a 2-month weight loss intervention to achieve ≥8% weight loss. The second phase was a 34-month weight loss maintenance intervention with two diets providing different amounts of protein and different glycemic indices, and two physical activity programs with different exercise intensities in a 2 x 2 factorial design. On investigation days, we assessed anthropometrics, glucose/lipid metabolism markers, and diet and exercise questionnaires under standardized procedures. Results: Diabetes-related markers improved during all four lifestyle interventions. Higher baseline TyG index (p < 0.001) was associated with greater reductions in body weight, fasting glucose, and triglyceride (TG), while a high TyG-waist phenotype predicted better TG responses, particularly in those randomized to physical activity (PA) of moderate intensity. Conclusions: Two novel indices of insulin resistance (TyG and TyG-waist) may allow for a more personalized approach to avoiding progression to T2D. Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT01777893 reference, identifier: NCT01777893. |
|---|---|
| Autores principais: | Navas-Carretero, Santiago |
| Outros Autores: | San-Cristobal, Rodrigo; Siig Vestentoft, Pia; Brand-Miller, Jennie C.; Jalo, Elli; Westerterp-Plantenga, Margriet; Simpson, Elizabeth J.; Handjieva-Darlenska, Teodora; Stratton, Gareth; Huttunen-Lenz, Maija; Lam, Tony; Muirhead, Roslyn; Poppitt, Sally; Pietiläinen, Kirsi H.; Adam, Tanja; Taylor, Moira A.; Handjiev, Svetoslav; McNarry, Melitta A.; Hansen, Sylvia; Brodie, Shannon; Silvestre, Marta P.; Macdonald, Ian A.; Boyadjieva, Nadka; Mackintosh, Kelly A.; Schlicht, Wolfgang; Liu, Amy; Larsen, Thomas M.; Fogelholm, Mikael; Raben, Anne; Martinez, J. Alfredo |
| Assunto: | carbohydrate metabolism diabetes hypertriglyceridemic-waist phenotype lipid markers obesity pre-diabetes precision nutrition triglycerides (PubChem CID: 5460048) Food Science Endocrinology, Diabetes and Metabolism Nutrition and Dietetics SDG 3 - Good Health and Well-being |
| Ano: | 2021 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| _version_ | 1868982734296186880 |
|---|---|
| author | Navas-Carretero, Santiago |
| author2 | San-Cristobal, Rodrigo Siig Vestentoft, Pia Brand-Miller, Jennie C. Jalo, Elli Westerterp-Plantenga, Margriet Simpson, Elizabeth J. Handjieva-Darlenska, Teodora Stratton, Gareth Huttunen-Lenz, Maija Lam, Tony Muirhead, Roslyn Poppitt, Sally Pietiläinen, Kirsi H. Adam, Tanja Taylor, Moira A. Handjiev, Svetoslav McNarry, Melitta A. Hansen, Sylvia Brodie, Shannon Silvestre, Marta P. Macdonald, Ian A. Boyadjieva, Nadka Mackintosh, Kelly A. Schlicht, Wolfgang Liu, Amy Larsen, Thomas M. Fogelholm, Mikael Raben, Anne Martinez, J. Alfredo |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Navas-Carretero, Santiago San-Cristobal, Rodrigo Siig Vestentoft, Pia Brand-Miller, Jennie C. Jalo, Elli Westerterp-Plantenga, Margriet Simpson, Elizabeth J. Handjieva-Darlenska, Teodora Stratton, Gareth Huttunen-Lenz, Maija Lam, Tony Muirhead, Roslyn Poppitt, Sally Pietiläinen, Kirsi H. Adam, Tanja Taylor, Moira A. Handjiev, Svetoslav McNarry, Melitta A. Hansen, Sylvia Brodie, Shannon Silvestre, Marta P. Macdonald, Ian A. Boyadjieva, Nadka Mackintosh, Kelly A. Schlicht, Wolfgang Liu, Amy Larsen, Thomas M. Fogelholm, Mikael Raben, Anne Martinez, J. Alfredo |
| author_role | author |
| contributor_name_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Frontiers Media RUN |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Navas-Carretero, Santiago\"},{\"Person.name\":\"San-Cristobal, Rodrigo\"},{\"Person.name\":\"Siig Vestentoft, Pia\"},{\"Person.name\":\"Brand-Miller, Jennie C.\"},{\"Person.name\":\"Jalo, Elli\"},{\"Person.name\":\"Westerterp-Plantenga, Margriet\"},{\"Person.name\":\"Simpson, Elizabeth J.\"},{\"Person.name\":\"Handjieva-Darlenska, Teodora\"},{\"Person.name\":\"Stratton, Gareth\"},{\"Person.name\":\"Huttunen-Lenz, Maija\"},{\"Person.name\":\"Lam, Tony\"},{\"Person.name\":\"Muirhead, Roslyn\"},{\"Person.name\":\"Poppitt, Sally\"},{\"Person.name\":\"Pietiläinen, Kirsi H.\"},{\"Person.name\":\"Adam, Tanja\"},{\"Person.name\":\"Taylor, Moira A.\"},{\"Person.name\":\"Handjiev, Svetoslav\"},{\"Person.name\":\"McNarry, Melitta A.\"},{\"Person.name\":\"Hansen, Sylvia\"},{\"Person.name\":\"Brodie, Shannon\"},{\"Person.name\":\"Silvestre, Marta P.\"},{\"Person.name\":\"Macdonald, Ian A.\"},{\"Person.name\":\"Boyadjieva, Nadka\"},{\"Person.name\":\"Mackintosh, Kelly A.\"},{\"Person.name\":\"Schlicht, Wolfgang\"},{\"Person.name\":\"Liu, Amy\"},{\"Person.name\":\"Larsen, Thomas M.\"},{\"Person.name\":\"Fogelholm, Mikael\"},{\"Person.name\":\"Raben, Anne\"},{\"Person.name\":\"Martinez, J. Alfredo\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Frontiers Media RUN |
| datacite.creators.creator.creatorName.fl_str_mv | Navas-Carretero, Santiago San-Cristobal, Rodrigo Siig Vestentoft, Pia Brand-Miller, Jennie C. Jalo, Elli Westerterp-Plantenga, Margriet Simpson, Elizabeth J. Handjieva-Darlenska, Teodora Stratton, Gareth Huttunen-Lenz, Maija Lam, Tony Muirhead, Roslyn Poppitt, Sally Pietiläinen, Kirsi H. Adam, Tanja Taylor, Moira A. Handjiev, Svetoslav McNarry, Melitta A. Hansen, Sylvia Brodie, Shannon Silvestre, Marta P. Macdonald, Ian A. Boyadjieva, Nadka Mackintosh, Kelly A. Schlicht, Wolfgang Liu, Amy Larsen, Thomas M. Fogelholm, Mikael Raben, Anne Martinez, J. Alfredo |
| datacite.date.Accepted.fl_str_mv | 2021-11-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2021-12-10T23:38:26Z |
| datacite.date.embargoed.fl_str_mv | 2021-12-10T23:38:26Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | carbohydrate metabolism diabetes hypertriglyceridemic-waist phenotype lipid markers obesity pre-diabetes precision nutrition triglycerides (PubChem CID: 5460048) Food Science Endocrinology, Diabetes and Metabolism Nutrition and Dietetics SDG 3 - Good Health and Well-being |
| datacite.titles.title.fl_str_mv | Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention A Controlled Post-hoc Trial |
| dc.contributor.none.fl_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Frontiers Media RUN |
| dc.creator.none.fl_str_mv | Navas-Carretero, Santiago San-Cristobal, Rodrigo Siig Vestentoft, Pia Brand-Miller, Jennie C. Jalo, Elli Westerterp-Plantenga, Margriet Simpson, Elizabeth J. Handjieva-Darlenska, Teodora Stratton, Gareth Huttunen-Lenz, Maija Lam, Tony Muirhead, Roslyn Poppitt, Sally Pietiläinen, Kirsi H. Adam, Tanja Taylor, Moira A. Handjiev, Svetoslav McNarry, Melitta A. Hansen, Sylvia Brodie, Shannon Silvestre, Marta P. Macdonald, Ian A. Boyadjieva, Nadka Mackintosh, Kelly A. Schlicht, Wolfgang Liu, Amy Larsen, Thomas M. Fogelholm, Mikael Raben, Anne Martinez, J. Alfredo |
| dc.date.Accepted.fl_str_mv | 2021-11-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2021-12-10T23:38:26Z |
| dc.date.embargoed.fl_str_mv | 2021-12-10T23:38:26Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10362/129004 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | carbohydrate metabolism diabetes hypertriglyceridemic-waist phenotype lipid markers obesity pre-diabetes precision nutrition triglycerides (PubChem CID: 5460048) Food Science Endocrinology, Diabetes and Metabolism Nutrition and Dietetics SDG 3 - Good Health and Well-being |
| dc.title.fl_str_mv | Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention A Controlled Post-hoc Trial |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Background: Individuals with pre-diabetes are commonly overweight and benefit from dietary and physical activity strategies aimed at decreasing body weight and hyperglycemia. Early insulin resistance can be estimated via the triglyceride glucose index {TyG = Ln [TG (mg/dl) × fasting plasma glucose (FPG) (mg/dl)/2]} and the hypertriglyceridemic-high waist phenotype (TyG-waist), based on TyG x waist circumference (WC) measurements. Both indices may be useful for implementing personalized metabolic management. In this secondary analysis of a randomized controlled trial (RCT), we aimed to determine whether the differences in baseline TyG values and TyG-waist phenotype predicted individual responses to type-2 diabetes (T2D) prevention programs. Methods: The present post-hoc analyses were conducted within the Prevention of Diabetes through Lifestyle intervention and population studies in Europe and around the world (PREVIEW) study completers (n = 899), a multi-center RCT conducted in eight countries (NCT01777893). The study aimed to reduce the incidence of T2D in a population with pre-diabetes during a 3-year randomized intervention with two sequential phases. The first phase was a 2-month weight loss intervention to achieve ≥8% weight loss. The second phase was a 34-month weight loss maintenance intervention with two diets providing different amounts of protein and different glycemic indices, and two physical activity programs with different exercise intensities in a 2 x 2 factorial design. On investigation days, we assessed anthropometrics, glucose/lipid metabolism markers, and diet and exercise questionnaires under standardized procedures. Results: Diabetes-related markers improved during all four lifestyle interventions. Higher baseline TyG index (p < 0.001) was associated with greater reductions in body weight, fasting glucose, and triglyceride (TG), while a high TyG-waist phenotype predicted better TG responses, particularly in those randomized to physical activity (PA) of moderate intensity. Conclusions: Two novel indices of insulin resistance (TyG and TyG-waist) may allow for a more personalized approach to avoiding progression to T2D. Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT01777893 reference, identifier: NCT01777893. |
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| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://run.unl.pt/bitstreams/460b9955-cd2a-4164-8a5f-1487499e2def/download |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10362/129004 |
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| institution | Universidade Nova de Lisboa |
| instname_str | Universidade Nova de Lisboa |
| language | eng |
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| network_name_str | Repositório Institucional da UNL |
| oai_identifier_str | oai:run.unl.pt:10362/129004 |
| organization_str_mv | urn:organizationAcronym:unl |
| person_str_mv | Navas-Carretero, Santiago San-Cristobal, Rodrigo Siig Vestentoft, Pia Brand-Miller, Jennie C. Jalo, Elli Westerterp-Plantenga, Margriet Simpson, Elizabeth J. Handjieva-Darlenska, Teodora Stratton, Gareth Huttunen-Lenz, Maija Lam, Tony Muirhead, Roslyn Poppitt, Sally Pietiläinen, Kirsi H. Adam, Tanja Taylor, Moira A. Handjiev, Svetoslav McNarry, Melitta A. Hansen, Sylvia Brodie, Shannon Silvestre, Marta P. Macdonald, Ian A. Boyadjieva, Nadka Mackintosh, Kelly A. Schlicht, Wolfgang Liu, Amy Larsen, Thomas M. Fogelholm, Mikael Raben, Anne Martinez, J. Alfredo |
| publishDate | 2021 |
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| spelling | engenBackground: Individuals with pre-diabetes are commonly overweight and benefit from dietary and physical activity strategies aimed at decreasing body weight and hyperglycemia. Early insulin resistance can be estimated via the triglyceride glucose index {TyG = Ln [TG (mg/dl) × fasting plasma glucose (FPG) (mg/dl)/2]} and the hypertriglyceridemic-high waist phenotype (TyG-waist), based on TyG x waist circumference (WC) measurements. Both indices may be useful for implementing personalized metabolic management. In this secondary analysis of a randomized controlled trial (RCT), we aimed to determine whether the differences in baseline TyG values and TyG-waist phenotype predicted individual responses to type-2 diabetes (T2D) prevention programs. Methods: The present post-hoc analyses were conducted within the Prevention of Diabetes through Lifestyle intervention and population studies in Europe and around the world (PREVIEW) study completers (n = 899), a multi-center RCT conducted in eight countries (NCT01777893). The study aimed to reduce the incidence of T2D in a population with pre-diabetes during a 3-year randomized intervention with two sequential phases. The first phase was a 2-month weight loss intervention to achieve ≥8% weight loss. The second phase was a 34-month weight loss maintenance intervention with two diets providing different amounts of protein and different glycemic indices, and two physical activity programs with different exercise intensities in a 2 x 2 factorial design. On investigation days, we assessed anthropometrics, glucose/lipid metabolism markers, and diet and exercise questionnaires under standardized procedures. Results: Diabetes-related markers improved during all four lifestyle interventions. Higher baseline TyG index (p < 0.001) was associated with greater reductions in body weight, fasting glucose, and triglyceride (TG), while a high TyG-waist phenotype predicted better TG responses, particularly in those randomized to physical activity (PA) of moderate intensity. Conclusions: Two novel indices of insulin resistance (TyG and TyG-waist) may allow for a more personalized approach to avoiding progression to T2D. Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT01777893 reference, identifier: NCT01777893.application/pdfenAppraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle InterventionSubtitleenA Controlled Post-hoc TrialNavas-Carretero, SantiagoSan-Cristobal, RodrigoSiig Vestentoft, PiaBrand-Miller, Jennie C.Jalo, ElliWesterterp-Plantenga, MargrietSimpson, Elizabeth J.Handjieva-Darlenska, TeodoraStratton, GarethHuttunen-Lenz, MaijaLam, TonyMuirhead, RoslynPoppitt, SallyPietiläinen, Kirsi H.Adam, TanjaTaylor, Moira A.Handjiev, SvetoslavMcNarry, Melitta A.Hansen, SylviaBrodie, ShannonSilvestre, Marta P.Macdonald, Ian A.Boyadjieva, NadkaMackintosh, Kelly A.Schlicht, WolfgangLiu, AmyLarsen, Thomas M.Fogelholm, MikaelRaben, AnneMartinez, J. AlfredoNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Frontiers MediaHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.ptISSNIsPartOf2296-861XURNIsPartOfPURE: 35038807URNIsPartOfPURE UUID: eb209c39-5383-41d2-9311-38a0153930caURNIsPartOfScopus: 85119271744URNIsPartOfORCID: /0000-0001-9327-2897/work/104582198DOIIsPartOf10.3389/fnut.2021.7336972021-12-10T23:38:26Z2021-11-012021-11-01T00:00:00ZHandlehttp://hdl.handle.net/10362/129004http://purl.org/coar/access_right/c_abf2open accesscarbohydrate metabolismdiabeteshypertriglyceridemic-waist phenotypelipid markersobesitypre-diabetesprecision nutritiontriglycerides (PubChem CID: 5460048)Food ScienceEndocrinology, Diabetes and MetabolismNutrition and DieteticsSDG 3 - Good Health and Well-being3616893 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/460b9955-cd2a-4164-8a5f-1487499e2def/download |
| spellingShingle | Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention Navas-Carretero, Santiago carbohydrate metabolism diabetes hypertriglyceridemic-waist phenotype lipid markers obesity pre-diabetes precision nutrition triglycerides (PubChem CID: 5460048) Food Science Endocrinology, Diabetes and Metabolism Nutrition and Dietetics SDG 3 - Good Health and Well-being |
| status | SINGLETON |
| subject.fl_str_mv | carbohydrate metabolism diabetes hypertriglyceridemic-waist phenotype lipid markers obesity pre-diabetes precision nutrition triglycerides (PubChem CID: 5460048) Food Science Endocrinology, Diabetes and Metabolism Nutrition and Dietetics SDG 3 - Good Health and Well-being |
| title | Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention |
| title_full | Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention |
| title_fullStr | Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention |
| title_full_unstemmed | Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention |
| title_short | Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention |
| title_sort | Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention |
| topic | carbohydrate metabolism diabetes hypertriglyceridemic-waist phenotype lipid markers obesity pre-diabetes precision nutrition triglycerides (PubChem CID: 5460048) Food Science Endocrinology, Diabetes and Metabolism Nutrition and Dietetics SDG 3 - Good Health and Well-being |
| topic_facet | carbohydrate metabolism diabetes hypertriglyceridemic-waist phenotype lipid markers obesity pre-diabetes precision nutrition triglycerides (PubChem CID: 5460048) Food Science Endocrinology, Diabetes and Metabolism Nutrition and Dietetics SDG 3 - Good Health and Well-being |
| url | http://hdl.handle.net/10362/129004 |
| visible | 1 |