Publicação
Right-sided brain lesions predominate among patients with lesional mania
| Resumo: | Despite claims that lesional mania is associated with right-hemisphere lesions, supporting evidence is scarce, and association with specific brain areas has not been demonstrated. Here, we aimed to test whether focal brain lesions in lesional mania are more often right- than left-sided, and if lesions converge on areas relevant to mood regulation. We thus performed a systematic literature search (PROSPERO registration CRD42016053675) on PubMed and Web-Of-Science, using terms that reflect diagnoses and structures of interest, as well as lesional mechanisms. Two researchers reviewed the articles separately according to PRISMA Guidelines, selecting reports of adult-onset hypomania, mania or mixed state following a focal brain lesion, for pooled-analyses of individual patient data. Eligible lesion images were manually traced onto the corresponding MNI space slices, and lesion topography analyzed using standard brain atlases. Using this approach, data from 211 lesional mania patients was extracted from 114 reports. Among 201 cases with focal lesions, more patients had lesions involving exclusively the right (60.7%) than exclusively the left (11.4%) hemisphere. In further analyses of 56 eligible lesion images, while findings should be considered cautiously given the potential for selection bias of published lesion images, right-sided predominance of lesions was confirmed across multiple brain regions, including the temporal lobe, fusiform gyrus and thalamus. These, and several frontal lobe areas, were also identified as preferential lesion sites in comparisons with control lesions. Such pooled-analyses, based on the most comprehensive dataset of lesional mania available to date, confirm a preferential association with right-hemisphere lesions, while suggesting that several brain areas/circuits, relevant to mood regulation, are most frequently affected. |
|---|---|
| Autores principais: | Barahona-Corrêa, J. Bernardo |
| Outros Autores: | Cotovio, Gonçalo; Costa, Rui M.; Ribeiro, Ricardo; Velosa, Ana; Silva, Vera Cruz e.; Sperber, Christoph; Karnath, Hans Otto; Senova, Suhan; Oliveira-Maia, Albino J.; Oliveira-Maia, AJ |
| Assunto: | Psychiatry and Mental health Cellular and Molecular Neuroscience Biological Psychiatry SDG 3 - Good Health and Well-being |
| Ano: | 2020 |
| País: | Portugal |
| Tipo de documento: | recensão |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| _version_ | 1868414274250997760 |
|---|---|
| author | Barahona-Corrêa, J. Bernardo |
| author2 | Cotovio, Gonçalo Costa, Rui M. Ribeiro, Ricardo Velosa, Ana Silva, Vera Cruz e. Sperber, Christoph Karnath, Hans Otto Senova, Suhan Oliveira-Maia, Albino J. Oliveira-Maia, AJ |
| author2_role | author author author author author author author author author author |
| author_facet | Barahona-Corrêa, J. Bernardo Cotovio, Gonçalo Costa, Rui M. Ribeiro, Ricardo Velosa, Ana Silva, Vera Cruz e. Sperber, Christoph Karnath, Hans Otto Senova, Suhan Oliveira-Maia, Albino J. Oliveira-Maia, AJ |
| author_role | author |
| contributor_name_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Springer Nature RUN |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Barahona-Corrêa, J. Bernardo\"},{\"Person.name\":\"Cotovio, Gonçalo\"},{\"Person.name\":\"Costa, Rui M.\"},{\"Person.name\":\"Ribeiro, Ricardo\"},{\"Person.name\":\"Velosa, Ana\"},{\"Person.name\":\"Silva, Vera Cruz e.\"},{\"Person.name\":\"Sperber, Christoph\"},{\"Person.name\":\"Karnath, Hans Otto\"},{\"Person.name\":\"Senova, Suhan\"},{\"Person.name\":\"Oliveira-Maia, Albino J.\"},{\"Person.name\":\"Oliveira-Maia, AJ\",\"Person.identifier.orcid\":\"0000-0001-5071-3007\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Springer Nature RUN |
| datacite.creators.creator.creatorName.fl_str_mv | Barahona-Corrêa, J. Bernardo Cotovio, Gonçalo Costa, Rui M. Ribeiro, Ricardo Velosa, Ana Silva, Vera Cruz e. Sperber, Christoph Karnath, Hans Otto Senova, Suhan Oliveira-Maia, Albino J. Oliveira-Maia, AJ |
| datacite.date.Accepted.fl_str_mv | 2020-05-12T00:00:00Z |
| datacite.date.available.fl_str_mv | 2020-06-03T00:55:28Z |
| datacite.date.embargoed.fl_str_mv | 2020-06-03T00:55:28Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Psychiatry and Mental health Cellular and Molecular Neuroscience Biological Psychiatry SDG 3 - Good Health and Well-being |
| datacite.titles.title.fl_str_mv | Right-sided brain lesions predominate among patients with lesional mania evidence from a systematic review and pooled lesion analysis |
| dc.contributor.none.fl_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Springer Nature RUN |
| dc.creator.none.fl_str_mv | Barahona-Corrêa, J. Bernardo Cotovio, Gonçalo Costa, Rui M. Ribeiro, Ricardo Velosa, Ana Silva, Vera Cruz e. Sperber, Christoph Karnath, Hans Otto Senova, Suhan Oliveira-Maia, Albino J. Oliveira-Maia, AJ |
| dc.date.Accepted.fl_str_mv | 2020-05-12T00:00:00Z |
| dc.date.available.fl_str_mv | 2020-06-03T00:55:28Z |
| dc.date.embargoed.fl_str_mv | 2020-06-03T00:55:28Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10362/98753 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Psychiatry and Mental health Cellular and Molecular Neuroscience Biological Psychiatry SDG 3 - Good Health and Well-being |
| dc.title.fl_str_mv | Right-sided brain lesions predominate among patients with lesional mania evidence from a systematic review and pooled lesion analysis |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_efa0 |
| description | Despite claims that lesional mania is associated with right-hemisphere lesions, supporting evidence is scarce, and association with specific brain areas has not been demonstrated. Here, we aimed to test whether focal brain lesions in lesional mania are more often right- than left-sided, and if lesions converge on areas relevant to mood regulation. We thus performed a systematic literature search (PROSPERO registration CRD42016053675) on PubMed and Web-Of-Science, using terms that reflect diagnoses and structures of interest, as well as lesional mechanisms. Two researchers reviewed the articles separately according to PRISMA Guidelines, selecting reports of adult-onset hypomania, mania or mixed state following a focal brain lesion, for pooled-analyses of individual patient data. Eligible lesion images were manually traced onto the corresponding MNI space slices, and lesion topography analyzed using standard brain atlases. Using this approach, data from 211 lesional mania patients was extracted from 114 reports. Among 201 cases with focal lesions, more patients had lesions involving exclusively the right (60.7%) than exclusively the left (11.4%) hemisphere. In further analyses of 56 eligible lesion images, while findings should be considered cautiously given the potential for selection bias of published lesion images, right-sided predominance of lesions was confirmed across multiple brain regions, including the temporal lobe, fusiform gyrus and thalamus. These, and several frontal lobe areas, were also identified as preferential lesion sites in comparisons with control lesions. Such pooled-analyses, based on the most comprehensive dataset of lesional mania available to date, confirm a preferential association with right-hemisphere lesions, while suggesting that several brain areas/circuits, relevant to mood regulation, are most frequently affected. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | review |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10362/98753 |
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| institution | Universidade Nova de Lisboa |
| instname_str | Universidade Nova de Lisboa |
| language | eng |
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| network_name_str | Repositório Institucional da UNL |
| oai_identifier_str | oai:run.unl.pt:10362/98753 |
| organization_str_mv | urn:organizationAcronym:unl |
| person_str_mv | Barahona-Corrêa, J. Bernardo Cotovio, Gonçalo Costa, Rui M. Ribeiro, Ricardo Velosa, Ana Silva, Vera Cruz e. Sperber, Christoph Karnath, Hans Otto Senova, Suhan Oliveira-Maia, Albino J. Oliveira-Maia, AJ Oliveira-Maia, AJ https://www.ciencia-id.pt/ED15-6691-FEC7 ED15-6691-FEC7 http://orcid.org/0000-0001-5071-3007 0000-0001-5071-3007 |
| publishDate | 2020 |
| reponame_str | Repositório Institucional da UNL |
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| spelling | engenDespite claims that lesional mania is associated with right-hemisphere lesions, supporting evidence is scarce, and association with specific brain areas has not been demonstrated. Here, we aimed to test whether focal brain lesions in lesional mania are more often right- than left-sided, and if lesions converge on areas relevant to mood regulation. We thus performed a systematic literature search (PROSPERO registration CRD42016053675) on PubMed and Web-Of-Science, using terms that reflect diagnoses and structures of interest, as well as lesional mechanisms. Two researchers reviewed the articles separately according to PRISMA Guidelines, selecting reports of adult-onset hypomania, mania or mixed state following a focal brain lesion, for pooled-analyses of individual patient data. Eligible lesion images were manually traced onto the corresponding MNI space slices, and lesion topography analyzed using standard brain atlases. Using this approach, data from 211 lesional mania patients was extracted from 114 reports. Among 201 cases with focal lesions, more patients had lesions involving exclusively the right (60.7%) than exclusively the left (11.4%) hemisphere. In further analyses of 56 eligible lesion images, while findings should be considered cautiously given the potential for selection bias of published lesion images, right-sided predominance of lesions was confirmed across multiple brain regions, including the temporal lobe, fusiform gyrus and thalamus. These, and several frontal lobe areas, were also identified as preferential lesion sites in comparisons with control lesions. Such pooled-analyses, based on the most comprehensive dataset of lesional mania available to date, confirm a preferential association with right-hemisphere lesions, while suggesting that several brain areas/circuits, relevant to mood regulation, are most frequently affected.application/pdfenRight-sided brain lesions predominate among patients with lesional maniaSubtitleenevidence from a systematic review and pooled lesion analysisBarahona-Corrêa, J. BernardoCotovio, GonçaloCosta, Rui M.Ribeiro, RicardoVelosa, AnaSilva, Vera Cruz e.Sperber, ChristophKarnath, Hans OttoSenova, SuhanOliveira-Maia, Albino J.PersonalOliveira-Maia, AJDSpacehttp://dspace.org/items/402bb6ca-e5db-422a-9d43-a807d4076d38DSpacehttp://dspace.org/items/402bb6ca-e5db-422a-9d43-a807d4076d38Oliveira-MaiaAlbino JorgeCiência IDhttps://www.ciencia-id.ptED15-6691-FEC7ORCIDhttp://orcid.org0000-0001-5071-3007Researcher IDhttps://www.researcherid.comB-7976-2009Scopus Author IDhttps://www.scopus.com14060820700NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Springer NatureHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.ptURNIsPartOfPURE: 18241046URNIsPartOfPURE UUID: b10122b5-1e7f-4e36-844c-a5608ea5c7baURNIsPartOfScopus: 85084515743URNIsPartOfPubMed: 32398699URNIsPartOfWOS: 000535812300006DOIIsPartOf10.1038/s41398-020-0811-02020-06-03T00:55:28Z2020-05-122020-05-12T00:00:00ZHandlehttp://hdl.handle.net/10362/98753http://purl.org/coar/access_right/c_abf2open accessPsychiatry and Mental healthCellular and Molecular NeuroscienceBiological PsychiatrySDG 3 - Good Health and Well-being2756542 bytesother research producthttp://purl.org/coar/resource_type/c_efa0reviewhttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/1abcca54-0a79-437e-ace6-eefecd327c4e/download |
| spellingShingle | Right-sided brain lesions predominate among patients with lesional mania Barahona-Corrêa, J. Bernardo Psychiatry and Mental health Cellular and Molecular Neuroscience Biological Psychiatry SDG 3 - Good Health and Well-being |
| status | SINGLETON |
| subject.fl_str_mv | Psychiatry and Mental health Cellular and Molecular Neuroscience Biological Psychiatry SDG 3 - Good Health and Well-being |
| title | Right-sided brain lesions predominate among patients with lesional mania |
| title_full | Right-sided brain lesions predominate among patients with lesional mania |
| title_fullStr | Right-sided brain lesions predominate among patients with lesional mania |
| title_full_unstemmed | Right-sided brain lesions predominate among patients with lesional mania |
| title_short | Right-sided brain lesions predominate among patients with lesional mania |
| title_sort | Right-sided brain lesions predominate among patients with lesional mania |
| topic | Psychiatry and Mental health Cellular and Molecular Neuroscience Biological Psychiatry SDG 3 - Good Health and Well-being |
| topic_facet | Psychiatry and Mental health Cellular and Molecular Neuroscience Biological Psychiatry SDG 3 - Good Health and Well-being |
| url | http://hdl.handle.net/10362/98753 |
| visible | 1 |