Publicação
Injectable composite systems based on microparticles in hydrogels for bioactive cargo controlled delivery
| Resumo: | Engineering drug delivery systems (DDS) aim to release bioactive cargo to a specific site within the human body safely and efficiently. Hydrogels have been used as delivery matrices in different studies due to their biocompatibility, biodegradability, and versatility in biomedical purposes. Microparticles have also been used as drug delivery systems for similar reasons. The combination of microparticles and hydrogels in a composite system has been the topic of many research works. These composite systems can be injected in loco as DDS. The hydrogel will serve as a barrier to protect the particles and retard the release of any bioactive cargo within the particles. Additionally, these systems allow different release profiles, where different loads can be released sequentially, thus allowing a synergistic treatment. The reported advantages from several studies of these systems can be of great use in biomedicine for the development of more effective DDS. This review will focus on in situ injectable microparticles in hydrogel composite DDS for biomedical purposes, where a compilation of different studies will be analysed and reported herein. |
|---|---|
| Autores principais: | Carrêlo, Henrique |
| Outros Autores: | Soares, Paula I. P.; Borges, João Paulo; Cidade, Maria Teresa |
| Assunto: | Bioactive cargo Biomedical applications Drug delivery systems Hydrogels Microparticles Bioengineering Biomaterials Organic Chemistry Polymers and Plastics |
| Ano: | 2021 |
| País: | Portugal |
| Tipo de documento: | recensão |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| _version_ | 1868414445168885760 |
|---|---|
| author | Carrêlo, Henrique |
| author2 | Soares, Paula I. P. Borges, João Paulo Cidade, Maria Teresa |
| author2_role | author author author |
| author_facet | Carrêlo, Henrique Soares, Paula I. P. Borges, João Paulo Cidade, Maria Teresa |
| author_role | author |
| contributor_name_str_mv | CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N) DCM - Departamento de Ciência dos Materiais MDPI - Multidisciplinary Digital Publishing Institute RUN |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Carrêlo, Henrique\"},{\"Person.name\":\"Soares, Paula I. P.\"},{\"Person.name\":\"Borges, João Paulo\"},{\"Person.name\":\"Cidade, Maria Teresa\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N) DCM - Departamento de Ciência dos Materiais MDPI - Multidisciplinary Digital Publishing Institute RUN |
| datacite.creators.creator.creatorName.fl_str_mv | Carrêlo, Henrique Soares, Paula I. P. Borges, João Paulo Cidade, Maria Teresa |
| datacite.date.Accepted.fl_str_mv | 2021-09-18T00:00:00Z |
| datacite.date.available.fl_str_mv | 2022-01-27T03:24:22Z |
| datacite.date.embargoed.fl_str_mv | 2022-01-27T03:24:22Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Bioactive cargo Biomedical applications Drug delivery systems Hydrogels Microparticles Bioengineering Biomaterials Organic Chemistry Polymers and Plastics |
| datacite.titles.title.fl_str_mv | Injectable composite systems based on microparticles in hydrogels for bioactive cargo controlled delivery |
| dc.contributor.none.fl_str_mv | CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N) DCM - Departamento de Ciência dos Materiais MDPI - Multidisciplinary Digital Publishing Institute RUN |
| dc.creator.none.fl_str_mv | Carrêlo, Henrique Soares, Paula I. P. Borges, João Paulo Cidade, Maria Teresa |
| dc.date.Accepted.fl_str_mv | 2021-09-18T00:00:00Z |
| dc.date.available.fl_str_mv | 2022-01-27T03:24:22Z |
| dc.date.embargoed.fl_str_mv | 2022-01-27T03:24:22Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10362/131640 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Bioactive cargo Biomedical applications Drug delivery systems Hydrogels Microparticles Bioengineering Biomaterials Organic Chemistry Polymers and Plastics |
| dc.title.fl_str_mv | Injectable composite systems based on microparticles in hydrogels for bioactive cargo controlled delivery |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_efa0 |
| description | Engineering drug delivery systems (DDS) aim to release bioactive cargo to a specific site within the human body safely and efficiently. Hydrogels have been used as delivery matrices in different studies due to their biocompatibility, biodegradability, and versatility in biomedical purposes. Microparticles have also been used as drug delivery systems for similar reasons. The combination of microparticles and hydrogels in a composite system has been the topic of many research works. These composite systems can be injected in loco as DDS. The hydrogel will serve as a barrier to protect the particles and retard the release of any bioactive cargo within the particles. Additionally, these systems allow different release profiles, where different loads can be released sequentially, thus allowing a synergistic treatment. The reported advantages from several studies of these systems can be of great use in biomedicine for the development of more effective DDS. This review will focus on in situ injectable microparticles in hydrogel composite DDS for biomedical purposes, where a compilation of different studies will be analysed and reported herein. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | review |
| fulltext.url.fl_str_mv | https://run.unl.pt/bitstreams/1dfe0734-0603-4b7a-bde5-7b6e650ff87b/download |
| funding.funder.alternateName_str_mv | FCT FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia |
| funding.name_str_mv | 6817 - DCRRNI ID |
| id | run_63d637dff72dc2eeae208fe3a2ecc08b |
| identifier.url.fl_str_mv | http://hdl.handle.net/10362/131640 |
| instacron_str | unl |
| institution | Universidade Nova de Lisboa |
| instname_str | Universidade Nova de Lisboa |
| language | eng |
| network_acronym_str | run |
| network_name_str | Repositório Institucional da UNL |
| oai_identifier_str | oai:run.unl.pt:10362/131640 |
| organization_str_mv | urn:organizationAcronym:unl |
| person_str_mv | Carrêlo, Henrique Soares, Paula I. P. Borges, João Paulo Cidade, Maria Teresa |
| publishDate | 2021 |
| reponame_str | Repositório Institucional da UNL |
| repository_id_str | urn:repositoryAcronym:run |
| service_str_mv | urn:repositoryAcronym:run |
| spelling | engenEngineering drug delivery systems (DDS) aim to release bioactive cargo to a specific site within the human body safely and efficiently. Hydrogels have been used as delivery matrices in different studies due to their biocompatibility, biodegradability, and versatility in biomedical purposes. Microparticles have also been used as drug delivery systems for similar reasons. The combination of microparticles and hydrogels in a composite system has been the topic of many research works. These composite systems can be injected in loco as DDS. The hydrogel will serve as a barrier to protect the particles and retard the release of any bioactive cargo within the particles. Additionally, these systems allow different release profiles, where different loads can be released sequentially, thus allowing a synergistic treatment. The reported advantages from several studies of these systems can be of great use in biomedicine for the development of more effective DDS. This review will focus on in situ injectable microparticles in hydrogel composite DDS for biomedical purposes, where a compilation of different studies will be analysed and reported herein.application/pdfenInjectable composite systems based on microparticles in hydrogels for bioactive cargo controlled deliveryCarrêlo, HenriqueSoares, Paula I. P.Borges, João PauloCidade, Maria TeresaCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DCM - Departamento de Ciência dos MateriaisMDPI - Multidisciplinary Digital Publishing InstituteHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.ptISSNIsPartOf2310-2861URNIsPartOfPURE: 34089231URNIsPartOfPURE UUID: d687efa9-7740-40c2-b9d4-30f2e0445d0bURNIsPartOfScopus: 85115786566URNIsPartOfPubMed: 34563033URNIsPartOfPubMedCentral: PMC8482158URNIsPartOfWOS: 000700635700001DOIIsPartOf10.3390/gels70301472022-01-27T03:24:22Z2021-09-182021-09-18T00:00:00ZHandlehttp://hdl.handle.net/10362/131640http://purl.org/coar/access_right/c_abf2open accessBioactive cargoBiomedical applicationsDrug delivery systemsHydrogelsMicroparticlesBioengineeringBiomaterialsOrganic ChemistryPolymers and Plastics62877549 bytesFundação para a Ciência e a TecnologiaInstitute of Nanostructures, Nanomodelling and Nanofabrication6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaSmart hydrogel-based Injectable systems for breast cancer theranosticsCrossref Funder IDhttp://doi.org/10.13039/501100001871other research producthttp://purl.org/coar/resource_type/c_efa0reviewhttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/1dfe0734-0603-4b7a-bde5-7b6e650ff87b/download |
| spellingShingle | Injectable composite systems based on microparticles in hydrogels for bioactive cargo controlled delivery Carrêlo, Henrique Bioactive cargo Biomedical applications Drug delivery systems Hydrogels Microparticles Bioengineering Biomaterials Organic Chemistry Polymers and Plastics |
| status | SINGLETON |
| subject.fl_str_mv | Bioactive cargo Biomedical applications Drug delivery systems Hydrogels Microparticles Bioengineering Biomaterials Organic Chemistry Polymers and Plastics |
| title | Injectable composite systems based on microparticles in hydrogels for bioactive cargo controlled delivery |
| title_full | Injectable composite systems based on microparticles in hydrogels for bioactive cargo controlled delivery |
| title_fullStr | Injectable composite systems based on microparticles in hydrogels for bioactive cargo controlled delivery |
| title_full_unstemmed | Injectable composite systems based on microparticles in hydrogels for bioactive cargo controlled delivery |
| title_short | Injectable composite systems based on microparticles in hydrogels for bioactive cargo controlled delivery |
| title_sort | Injectable composite systems based on microparticles in hydrogels for bioactive cargo controlled delivery |
| topic | Bioactive cargo Biomedical applications Drug delivery systems Hydrogels Microparticles Bioengineering Biomaterials Organic Chemistry Polymers and Plastics |
| topic_facet | Bioactive cargo Biomedical applications Drug delivery systems Hydrogels Microparticles Bioengineering Biomaterials Organic Chemistry Polymers and Plastics |
| url | http://hdl.handle.net/10362/131640 |
| visible | 1 |