Publicação
Development of dog immune system
| Resumo: | Immune system recognize and fight back foreign microorganisms and inner modifications that lead to deficient cell and tissue functions. During a dog's life, the immune system needs to adapt to different physiological conditions, assuring surveillance and protection in a careful and controlled way. Pregnancy alters normal homeostasis, requiring a balance between immunity and tolerance. The embryos and fetus should be protected from infections, while the female dog must tolerate the growing of semi-allografts in her uterus. After birth, newborn puppies are at great risk of developing infectious diseases, because their immune system is in development and immune memory is absent. Passive transfer of immunity through colostrum is fundamental for puppy survival in the first weeks of life, but hampers the development of an active immune response to vaccination. At the end of life, dogs experience a decline in the structure and functional competence of the immune system, compromising the immune responses to novel antigenic challenges, such as infections and vaccines. Therefore, the current article reviews the general processes related to the development of the dog´s immune system, providing an overview of immune activity throughout the dog's life and its implications in canine health, and highlighting priority research goals. |
|---|---|
| Autores principais: | Pereira, Maria A. |
| Outros Autores: | Valério-Bolas, Ana; Cátia, Saraiva-Marques,; Graça Maria, Alexandre-Pires,; da Fonseca, Isabel Pereira; Santos-Gomes, G |
| Assunto: | Dog Immune system Immunity Immunity development Passive immune transfer SDG 3 - Good Health and Well-being |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | recensão |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| _version_ | 1868413862765658112 |
|---|---|
| author | Pereira, Maria A. |
| author2 | Valério-Bolas, Ana Cátia, Saraiva-Marques, Graça Maria, Alexandre-Pires, da Fonseca, Isabel Pereira Santos-Gomes, G |
| author2_role | author author author author author |
| author_facet | Pereira, Maria A. Valério-Bolas, Ana Cátia, Saraiva-Marques, Graça Maria, Alexandre-Pires, da Fonseca, Isabel Pereira Santos-Gomes, G |
| author_role | author |
| contributor_name_str_mv | Instituto de Higiene e Medicina Tropical (IHMT) Global Health and Tropical Medicine (GHTM) Vector borne diseases and pathogens (VBD) MDPI - Multidisciplinary Digital Publishing Institute RUN |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Pereira, Maria A.\"},{\"Person.name\":\"Valério-Bolas, Ana\"},{\"Person.name\":\"Cátia, Saraiva-Marques,\"},{\"Person.name\":\"Graça Maria, Alexandre-Pires,\"},{\"Person.name\":\"da Fonseca, Isabel Pereira\"},{\"Person.name\":\"Santos-Gomes, G\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Instituto de Higiene e Medicina Tropical (IHMT) Global Health and Tropical Medicine (GHTM) Vector borne diseases and pathogens (VBD) MDPI - Multidisciplinary Digital Publishing Institute RUN |
| datacite.creators.creator.creatorName.fl_str_mv | Pereira, Maria A. Valério-Bolas, Ana Cátia, Saraiva-Marques, Graça Maria, Alexandre-Pires, da Fonseca, Isabel Pereira Santos-Gomes, G |
| datacite.date.Accepted.fl_str_mv | 2019-10-21T00:00:00Z |
| datacite.date.available.fl_str_mv | 2021-05-01T22:47:13Z |
| datacite.date.embargoed.fl_str_mv | 2021-05-01T22:47:13Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Dog Immune system Immunity Immunity development Passive immune transfer SDG 3 - Good Health and Well-being |
| datacite.titles.title.fl_str_mv | Development of dog immune system from in uterus to elderly |
| dc.contributor.none.fl_str_mv | Instituto de Higiene e Medicina Tropical (IHMT) Global Health and Tropical Medicine (GHTM) Vector borne diseases and pathogens (VBD) MDPI - Multidisciplinary Digital Publishing Institute RUN |
| dc.creator.none.fl_str_mv | Pereira, Maria A. Valério-Bolas, Ana Cátia, Saraiva-Marques, Graça Maria, Alexandre-Pires, da Fonseca, Isabel Pereira Santos-Gomes, G |
| dc.date.Accepted.fl_str_mv | 2019-10-21T00:00:00Z |
| dc.date.available.fl_str_mv | 2021-05-01T22:47:13Z |
| dc.date.embargoed.fl_str_mv | 2021-05-01T22:47:13Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10362/116590 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Dog Immune system Immunity Immunity development Passive immune transfer SDG 3 - Good Health and Well-being |
| dc.title.fl_str_mv | Development of dog immune system from in uterus to elderly |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_efa0 |
| description | Immune system recognize and fight back foreign microorganisms and inner modifications that lead to deficient cell and tissue functions. During a dog's life, the immune system needs to adapt to different physiological conditions, assuring surveillance and protection in a careful and controlled way. Pregnancy alters normal homeostasis, requiring a balance between immunity and tolerance. The embryos and fetus should be protected from infections, while the female dog must tolerate the growing of semi-allografts in her uterus. After birth, newborn puppies are at great risk of developing infectious diseases, because their immune system is in development and immune memory is absent. Passive transfer of immunity through colostrum is fundamental for puppy survival in the first weeks of life, but hampers the development of an active immune response to vaccination. At the end of life, dogs experience a decline in the structure and functional competence of the immune system, compromising the immune responses to novel antigenic challenges, such as infections and vaccines. Therefore, the current article reviews the general processes related to the development of the dog´s immune system, providing an overview of immune activity throughout the dog's life and its implications in canine health, and highlighting priority research goals. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | review |
| fulltext.url.fl_str_mv | https://run.unl.pt/bitstreams/18753f62-3747-4b5e-afbb-77180be3bc7f/download |
| id | run_6dc16dc4e55ffa70077bdbe1f1cd18da |
| identifier.url.fl_str_mv | http://hdl.handle.net/10362/116590 |
| instacron_str | unl |
| institution | Universidade Nova de Lisboa |
| instname_str | Universidade Nova de Lisboa |
| language | eng |
| network_acronym_str | run |
| network_name_str | Repositório Institucional da UNL |
| oai_identifier_str | oai:run.unl.pt:10362/116590 |
| organization_str_mv | urn:organizationAcronym:unl |
| person_str_mv | Pereira, Maria A. Valério-Bolas, Ana Cátia, Saraiva-Marques, Graça Maria, Alexandre-Pires, da Fonseca, Isabel Pereira Santos-Gomes, G |
| publishDate | 2019 |
| reponame_str | Repositório Institucional da UNL |
| repository_id_str | urn:repositoryAcronym:run |
| service_str_mv | urn:repositoryAcronym:run |
| spelling | engenImmune system recognize and fight back foreign microorganisms and inner modifications that lead to deficient cell and tissue functions. During a dog's life, the immune system needs to adapt to different physiological conditions, assuring surveillance and protection in a careful and controlled way. Pregnancy alters normal homeostasis, requiring a balance between immunity and tolerance. The embryos and fetus should be protected from infections, while the female dog must tolerate the growing of semi-allografts in her uterus. After birth, newborn puppies are at great risk of developing infectious diseases, because their immune system is in development and immune memory is absent. Passive transfer of immunity through colostrum is fundamental for puppy survival in the first weeks of life, but hampers the development of an active immune response to vaccination. At the end of life, dogs experience a decline in the structure and functional competence of the immune system, compromising the immune responses to novel antigenic challenges, such as infections and vaccines. Therefore, the current article reviews the general processes related to the development of the dog´s immune system, providing an overview of immune activity throughout the dog's life and its implications in canine health, and highlighting priority research goals.application/pdfenDevelopment of dog immune systemSubtitleenfrom in uterus to elderlyPereira, Maria A.Valério-Bolas, AnaCátia, Saraiva-Marques,Graça Maria, Alexandre-Pires,da Fonseca, Isabel PereiraSantos-Gomes, GInstituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)Vector borne diseases and pathogens (VBD)MDPI - Multidisciplinary Digital Publishing InstituteHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.ptISSNIsPartOf2306-7381URNIsPartOfPURE: 17174687URNIsPartOfPURE UUID: cd64b7c8-3992-4cfa-b15f-7c9f7a283e5cURNIsPartOfScopus: 85076680565URNIsPartOfPubMed: 31640234URNIsPartOfPubMedCentral: PMC6958461DOIIsPartOf10.3390/vetsci60400832021-05-01T22:47:13Z2019-10-212019-10-21T00:00:00ZHandlehttp://hdl.handle.net/10362/116590http://purl.org/coar/access_right/c_abf2open accessDogImmune systemImmunityImmunity developmentPassive immune transferSDG 3 - Good Health and Well-being1097924 bytesother research producthttp://purl.org/coar/resource_type/c_efa0reviewhttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/18753f62-3747-4b5e-afbb-77180be3bc7f/download |
| spellingShingle | Development of dog immune system Pereira, Maria A. Dog Immune system Immunity Immunity development Passive immune transfer SDG 3 - Good Health and Well-being |
| status | SINGLETON |
| subject.fl_str_mv | Dog Immune system Immunity Immunity development Passive immune transfer SDG 3 - Good Health and Well-being |
| title | Development of dog immune system |
| title_full | Development of dog immune system |
| title_fullStr | Development of dog immune system |
| title_full_unstemmed | Development of dog immune system |
| title_short | Development of dog immune system |
| title_sort | Development of dog immune system |
| topic | Dog Immune system Immunity Immunity development Passive immune transfer SDG 3 - Good Health and Well-being |
| topic_facet | Dog Immune system Immunity Immunity development Passive immune transfer SDG 3 - Good Health and Well-being |
| url | http://hdl.handle.net/10362/116590 |
| visible | 1 |