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Harnessing complex metabolic signatures to predict drug efficacy in ovarian cancer

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Resumo:"Ovarian carcinoma (OvC) is the most lethal gynecologic malignancy. Unfortunately, most cases are diagnosed at the later stages of the disease, impacting patient outcomes, resulting in a 5-year survival rate of less than 40%. The standard-of-care (SOC) treatment consists of cytoreduction surgery for tumor debulking and adjuvant chemotherapy, comprising a combination of platinum (cisplatin or carboplatin) with taxane (paclitaxel or docetaxel) agents.(...)"
Autores principais:Mendes, Ana Rita Soares
Assunto:precision medicine ovarian cancer
Ano:2022
País:Portugal
Tipo de documento:tese de doutoramento
Tipo de acesso:acesso aberto
Instituição associada:Universidade Nova de Lisboa
Idioma:inglês
Origem:Repositório Institucional da UNL
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author Mendes, Ana Rita Soares
author_facet Mendes, Ana Rita Soares
author_role author
contributor_name_str_mv Isidro, Inês
Brito, Catarina
RUN
country_str PT
creators_json_txt [{\"Person.name\":\"Mendes, Ana Rita Soares\"}]
datacite.contributors.contributor.contributorName.fl_str_mv Isidro, Inês
Brito, Catarina
RUN
datacite.creators.creator.creatorName.fl_str_mv Mendes, Ana Rita Soares
datacite.date.Accepted.fl_str_mv 2022-07-04T00:00:00Z
datacite.date.available.fl_str_mv 2023-07-31T00:33:51Z
datacite.date.embargoed.fl_str_mv 2023-07-31T00:33:51Z
datacite.rights.fl_str_mv http://purl.org/coar/access_right/c_abf2
datacite.subjects.subject.fl_str_mv precision medicine
ovarian cancer
datacite.titles.title.fl_str_mv Harnessing complex metabolic signatures to predict drug efficacy in ovarian cancer
dc.contributor.none.fl_str_mv Isidro, Inês
Brito, Catarina
RUN
dc.creator.none.fl_str_mv Mendes, Ana Rita Soares
dc.date.Accepted.fl_str_mv 2022-07-04T00:00:00Z
dc.date.available.fl_str_mv 2023-07-31T00:33:51Z
dc.date.embargoed.fl_str_mv 2023-07-31T00:33:51Z
dc.format.none.fl_str_mv application/pdf
dc.identifier.none.fl_str_mv http://hdl.handle.net/10362/143167
dc.language.none.fl_str_mv eng
dc.rights.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.subject.none.fl_str_mv precision medicine
ovarian cancer
dc.title.fl_str_mv Harnessing complex metabolic signatures to predict drug efficacy in ovarian cancer
dc.type.none.fl_str_mv http://purl.org/coar/resource_type/c_db06
description "Ovarian carcinoma (OvC) is the most lethal gynecologic malignancy. Unfortunately, most cases are diagnosed at the later stages of the disease, impacting patient outcomes, resulting in a 5-year survival rate of less than 40%. The standard-of-care (SOC) treatment consists of cytoreduction surgery for tumor debulking and adjuvant chemotherapy, comprising a combination of platinum (cisplatin or carboplatin) with taxane (paclitaxel or docetaxel) agents.(...)"
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funder_facet_str_mv FCT{{{_:::_}}}Fundação para a Ciência e a Tecnologia
funding.funder.alternateName_str_mv FCT
funding.funder.identifier_str_mv http://doi.org/10.13039/501100001871
funding.funder.name_str_mv Fundação para a Ciência e a Tecnologia
id run_739b84e5f46338cc8e5bde0c19f7b037
identifier.url.fl_str_mv http://hdl.handle.net/10362/143167
inst_facet_str urn:organizationAcronym:unl{{{_:::_}}}Universidade Nova de Lisboa
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institution Universidade Nova de Lisboa
instname_str Universidade Nova de Lisboa
language eng
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network_name_str Repositório Institucional da UNL
oai_identifier_str oai:run.unl.pt:10362/143167
organization_str_mv urn:organizationAcronym:unl
person_str_mv Mendes, Ana Rita Soares
publishDate 2022
repo_facet_str urn:repositoryAcronym:run{{{_:::_}}}Repositório Institucional da UNL
reponame_str Repositório Institucional da UNL
repository_id_str urn:repositoryAcronym:run
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spelling engpt_PT"Ovarian carcinoma (OvC) is the most lethal gynecologic malignancy. Unfortunately, most cases are diagnosed at the later stages of the disease, impacting patient outcomes, resulting in a 5-year survival rate of less than 40%. The standard-of-care (SOC) treatment consists of cytoreduction surgery for tumor debulking and adjuvant chemotherapy, comprising a combination of platinum (cisplatin or carboplatin) with taxane (paclitaxel or docetaxel) agents.(...)"application/pdfpt_PTHarnessing complex metabolic signatures to predict drug efficacy in ovarian cancerMendes, Ana Rita SoaresIsidro, InêsBrito, CatarinaHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.ptURNurn:tid:1017245352023-07-31T00:33:51Z2022-07-042022-022022-07-04T00:00:00ZHandlehttp://hdl.handle.net/10362/143167http://purl.org/coar/access_right/c_abf2open accessprecision medicineovarian cancer8093444 bytesFundação para a Ciência e a Tecnologiaalterado para: A precision medicine platform using patient derived cancer cell models to predict drug efficacy.Crossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_db06doctoral thesishttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/622c4779-3dd3-4805-b0a9-ae17470fb440/download
spellingShingle Harnessing complex metabolic signatures to predict drug efficacy in ovarian cancer
Mendes, Ana Rita Soares
precision medicine
ovarian cancer
status SINGLETON
subject.fl_str_mv precision medicine
ovarian cancer
title Harnessing complex metabolic signatures to predict drug efficacy in ovarian cancer
title_full Harnessing complex metabolic signatures to predict drug efficacy in ovarian cancer
title_fullStr Harnessing complex metabolic signatures to predict drug efficacy in ovarian cancer
title_full_unstemmed Harnessing complex metabolic signatures to predict drug efficacy in ovarian cancer
title_short Harnessing complex metabolic signatures to predict drug efficacy in ovarian cancer
title_sort Harnessing complex metabolic signatures to predict drug efficacy in ovarian cancer
topic precision medicine
ovarian cancer
topic_facet precision medicine
ovarian cancer
url http://hdl.handle.net/10362/143167
visible 1