Publicação
Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp.
| Resumo: | Invasive fungal infections represent a global health threat. They are associated with high mortality and morbidity rates, partly due to the ineffectiveness of the available antifungal agents. The rampant increase in infections recalcitrant to the current antifungals has worsened this scenario and made the discovery of new and more effective antifungals a pressing health issue. In this study, 65 extracts from marine organisms of the Yucatan Peninsula, Mexico, were screened for antifungal activity against Candida albicans and Candida glabrata, two of the most prevalent fungal species that cause nosocomial invasive fungal infections worldwide. A total of 51 sponges, 13 ascidians and 1 gorgonian were collected from the coral reef and mangrove forest in the Yucatan Peninsula (Mexico) and extracted with organic solvents. Nine crude extracts showed potent antifungal activity, of which four extracts from the sponge species Aiolochroia crassa, Amphimedon compressa, Monanchora arbuscula and Agelas citrina had promising activity against Candida spp. Bioassay-guided fractionation of the M. arbuscula extract revealed the remarkable fungicidal activity of some fractions. Analysis of the chemical composition of one of the most active fractions by UHPLC-HRMS and NMR indicated the presence of mirabilin B and penaresidin B, and their contribution to the observed antifungal activity is discussed. Overall, this work highlights marine organisms of the Yucatan Peninsula as important reservoirs of natural products with promising fungicidal activity, which may greatly advance the treatment of invasive fungal infections, especially those afflicting immunosuppressed patients. |
|---|---|
| Autores principais: | Pech-Puch, Dawrin |
| Outros Autores: | Grilo, Diana; Calva-Pérez, Susana Eunice; Pedras, Andreia; Villegas-Hernández, Harold; Guillén-Hernández, Sergio; Díaz-Gamboa, Raúl; Tunjano, Mateo Forero; Rodríguez, Jaime; Lenis-Rojas, Oscar A.; Jiménez, Carlos; Pimentel, Catarina |
| Assunto: | antifungal Candida marine natural products Yucatan Peninsula Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry SDG 14 - Life Below Water |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| _version_ | 1868983090689343488 |
|---|---|
| author | Pech-Puch, Dawrin |
| author2 | Grilo, Diana Calva-Pérez, Susana Eunice Pedras, Andreia Villegas-Hernández, Harold Guillén-Hernández, Sergio Díaz-Gamboa, Raúl Tunjano, Mateo Forero Rodríguez, Jaime Lenis-Rojas, Oscar A. Jiménez, Carlos Pimentel, Catarina |
| author2_role | author author author author author author author author author author author |
| author_facet | Pech-Puch, Dawrin Grilo, Diana Calva-Pérez, Susana Eunice Pedras, Andreia Villegas-Hernández, Harold Guillén-Hernández, Sergio Díaz-Gamboa, Raúl Tunjano, Mateo Forero Rodríguez, Jaime Lenis-Rojas, Oscar A. Jiménez, Carlos Pimentel, Catarina |
| author_role | author |
| contributor_name_str_mv | Instituto de Tecnologia Química e Biológica António Xavier (ITQB) MDPI - Multidisciplinary Digital Publishing Institute RUN |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Pech-Puch, Dawrin\"},{\"Person.name\":\"Grilo, Diana\"},{\"Person.name\":\"Calva-Pérez, Susana Eunice\"},{\"Person.name\":\"Pedras, Andreia\"},{\"Person.name\":\"Villegas-Hernández, Harold\"},{\"Person.name\":\"Guillén-Hernández, Sergio\"},{\"Person.name\":\"Díaz-Gamboa, Raúl\"},{\"Person.name\":\"Tunjano, Mateo Forero\"},{\"Person.name\":\"Rodríguez, Jaime\"},{\"Person.name\":\"Lenis-Rojas, Oscar A.\"},{\"Person.name\":\"Jiménez, Carlos\"},{\"Person.name\":\"Pimentel, Catarina\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Instituto de Tecnologia Química e Biológica António Xavier (ITQB) MDPI - Multidisciplinary Digital Publishing Institute RUN |
| datacite.creators.creator.creatorName.fl_str_mv | Pech-Puch, Dawrin Grilo, Diana Calva-Pérez, Susana Eunice Pedras, Andreia Villegas-Hernández, Harold Guillén-Hernández, Sergio Díaz-Gamboa, Raúl Tunjano, Mateo Forero Rodríguez, Jaime Lenis-Rojas, Oscar A. Jiménez, Carlos Pimentel, Catarina |
| datacite.date.Accepted.fl_str_mv | 2023-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2023-09-29T22:21:33Z |
| datacite.date.embargoed.fl_str_mv | 2023-09-29T22:21:33Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | antifungal Candida marine natural products Yucatan Peninsula Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry SDG 14 - Life Below Water |
| datacite.titles.title.fl_str_mv | Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp. |
| dc.contributor.none.fl_str_mv | Instituto de Tecnologia Química e Biológica António Xavier (ITQB) MDPI - Multidisciplinary Digital Publishing Institute RUN |
| dc.creator.none.fl_str_mv | Pech-Puch, Dawrin Grilo, Diana Calva-Pérez, Susana Eunice Pedras, Andreia Villegas-Hernández, Harold Guillén-Hernández, Sergio Díaz-Gamboa, Raúl Tunjano, Mateo Forero Rodríguez, Jaime Lenis-Rojas, Oscar A. Jiménez, Carlos Pimentel, Catarina |
| dc.date.Accepted.fl_str_mv | 2023-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2023-09-29T22:21:33Z |
| dc.date.embargoed.fl_str_mv | 2023-09-29T22:21:33Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10362/158475 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | antifungal Candida marine natural products Yucatan Peninsula Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry SDG 14 - Life Below Water |
| dc.title.fl_str_mv | Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp. |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Invasive fungal infections represent a global health threat. They are associated with high mortality and morbidity rates, partly due to the ineffectiveness of the available antifungal agents. The rampant increase in infections recalcitrant to the current antifungals has worsened this scenario and made the discovery of new and more effective antifungals a pressing health issue. In this study, 65 extracts from marine organisms of the Yucatan Peninsula, Mexico, were screened for antifungal activity against Candida albicans and Candida glabrata, two of the most prevalent fungal species that cause nosocomial invasive fungal infections worldwide. A total of 51 sponges, 13 ascidians and 1 gorgonian were collected from the coral reef and mangrove forest in the Yucatan Peninsula (Mexico) and extracted with organic solvents. Nine crude extracts showed potent antifungal activity, of which four extracts from the sponge species Aiolochroia crassa, Amphimedon compressa, Monanchora arbuscula and Agelas citrina had promising activity against Candida spp. Bioassay-guided fractionation of the M. arbuscula extract revealed the remarkable fungicidal activity of some fractions. Analysis of the chemical composition of one of the most active fractions by UHPLC-HRMS and NMR indicated the presence of mirabilin B and penaresidin B, and their contribution to the observed antifungal activity is discussed. Overall, this work highlights marine organisms of the Yucatan Peninsula as important reservoirs of natural products with promising fungicidal activity, which may greatly advance the treatment of invasive fungal infections, especially those afflicting immunosuppressed patients. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://run.unl.pt/bitstreams/7a39283e-ee53-4638-9bab-c41f6bc5cb57/download |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10362/158475 |
| inst_facet_str | urn:organizationAcronym:unl{{{_:::_}}}Universidade Nova de Lisboa |
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| institution | Universidade Nova de Lisboa |
| instname_str | Universidade Nova de Lisboa |
| language | eng |
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| network_name_str | Repositório Institucional da UNL |
| oai_identifier_str | oai:run.unl.pt:10362/158475 |
| organization_str_mv | urn:organizationAcronym:unl |
| person_str_mv | Pech-Puch, Dawrin Grilo, Diana Calva-Pérez, Susana Eunice Pedras, Andreia Villegas-Hernández, Harold Guillén-Hernández, Sergio Díaz-Gamboa, Raúl Tunjano, Mateo Forero Rodríguez, Jaime Lenis-Rojas, Oscar A. Jiménez, Carlos Pimentel, Catarina |
| publishDate | 2023 |
| repo_facet_str | urn:repositoryAcronym:run{{{_:::_}}}Repositório Institucional da UNL |
| reponame_str | Repositório Institucional da UNL |
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| spelling | engenInvasive fungal infections represent a global health threat. They are associated with high mortality and morbidity rates, partly due to the ineffectiveness of the available antifungal agents. The rampant increase in infections recalcitrant to the current antifungals has worsened this scenario and made the discovery of new and more effective antifungals a pressing health issue. In this study, 65 extracts from marine organisms of the Yucatan Peninsula, Mexico, were screened for antifungal activity against Candida albicans and Candida glabrata, two of the most prevalent fungal species that cause nosocomial invasive fungal infections worldwide. A total of 51 sponges, 13 ascidians and 1 gorgonian were collected from the coral reef and mangrove forest in the Yucatan Peninsula (Mexico) and extracted with organic solvents. Nine crude extracts showed potent antifungal activity, of which four extracts from the sponge species Aiolochroia crassa, Amphimedon compressa, Monanchora arbuscula and Agelas citrina had promising activity against Candida spp. Bioassay-guided fractionation of the M. arbuscula extract revealed the remarkable fungicidal activity of some fractions. Analysis of the chemical composition of one of the most active fractions by UHPLC-HRMS and NMR indicated the presence of mirabilin B and penaresidin B, and their contribution to the observed antifungal activity is discussed. Overall, this work highlights marine organisms of the Yucatan Peninsula as important reservoirs of natural products with promising fungicidal activity, which may greatly advance the treatment of invasive fungal infections, especially those afflicting immunosuppressed patients.application/pdfenAntifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp.Pech-Puch, DawrinGrilo, DianaCalva-Pérez, Susana EunicePedras, AndreiaVillegas-Hernández, HaroldGuillén-Hernández, SergioDíaz-Gamboa, RaúlTunjano, Mateo ForeroRodríguez, JaimeLenis-Rojas, Oscar A.Jiménez, CarlosPimentel, CatarinaInstituto de Tecnologia Química e Biológica António Xavier (ITQB)MDPI - Multidisciplinary Digital Publishing InstituteHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.ptISSNIsPartOf1420-3049URNIsPartOfPURE: 72096069URNIsPartOfPURE UUID: 0d27383b-c24a-4409-955f-cbb22bf7b663URNIsPartOfScopus: 85146826370URNIsPartOfPubMed: 36677663DOIIsPartOf10.3390/molecules280206062023-09-29T22:21:33Z2023-012023-01-01T00:00:00ZHandlehttp://hdl.handle.net/10362/158475http://purl.org/coar/access_right/c_abf2open accessantifungalCandidamarine natural productsYucatan PeninsulaAnalytical ChemistryChemistry (miscellaneous)Molecular MedicinePharmaceutical ScienceDrug DiscoveryPhysical and Theoretical ChemistryOrganic ChemistrySDG 14 - Life Below Water3220983 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/7a39283e-ee53-4638-9bab-c41f6bc5cb57/download |
| spellingShingle | Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp. Pech-Puch, Dawrin antifungal Candida marine natural products Yucatan Peninsula Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry SDG 14 - Life Below Water |
| status | SINGLETON |
| subject.fl_str_mv | antifungal Candida marine natural products Yucatan Peninsula Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry SDG 14 - Life Below Water |
| title | Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp. |
| title_full | Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp. |
| title_fullStr | Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp. |
| title_full_unstemmed | Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp. |
| title_short | Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp. |
| title_sort | Antifungal Potential of Marine Organisms of the Yucatan Peninsula (Mexico) against Medically Important Candida spp. |
| topic | antifungal Candida marine natural products Yucatan Peninsula Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry SDG 14 - Life Below Water |
| topic_facet | antifungal Candida marine natural products Yucatan Peninsula Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry SDG 14 - Life Below Water |
| url | http://hdl.handle.net/10362/158475 |
| visible | 1 |