Publicação
Low-energy electrons transform the nimorazole molecule into a radiosensitiser
| Resumo: | While matter is irradiated with highly-energetic particles, it may become chemically modified. Thereby, the reactions of free low-energy electrons (LEEs) formed as secondary particles play an important role. It is unknown to what degree and by which mechanism LEEs contribute to the action of electron-affinic radiosensitisers applied in radiotherapy of hypoxic tumours. Here we show that LEEs effectively cause the reduction of the radiosensitiser nimorazole via associative electron attachment with the cross-section exceeding most of known molecules. This supports the hypothesis that nimorazole is selectively cytotoxic to tumour cells due to reduction of the molecule as prerequisite for accumulation in the cell. In contrast, dissociative electron attachment, commonly believed to be the source of chemical activity of LEEs, represents only a minor reaction channel which is further suppressed upon hydration. Our results show that LEEs may strongly contribute to the radiosensitising effect of nimorazole via associative electron attachment. |
|---|---|
| Autores principais: | Meißner, Rebecca |
| Outros Autores: | Kočišek, Jaroslav; Feketeová, Linda; Fedor, Juraj; Fárník, Michal; Limão-Vieira, Paulo; Illenberger, Eugen; Denifl, Stephan |
| Assunto: | General Chemistry General Biochemistry,Genetics and Molecular Biology General Physics and Astronomy |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| _version_ | 1868982837040906240 |
|---|---|
| author | Meißner, Rebecca |
| author2 | Kočišek, Jaroslav Feketeová, Linda Fedor, Juraj Fárník, Michal Limão-Vieira, Paulo Illenberger, Eugen Denifl, Stephan |
| author2_role | author author author author author author author |
| author_facet | Meißner, Rebecca Kočišek, Jaroslav Feketeová, Linda Fedor, Juraj Fárník, Michal Limão-Vieira, Paulo Illenberger, Eugen Denifl, Stephan |
| author_role | author |
| contributor_name_str_mv | DF – Departamento de Física CeFITec – Centro de Física e Investigação Tecnológica Nature Portfolio RUN |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Meißner, Rebecca\"},{\"Person.name\":\"Kočišek, Jaroslav\"},{\"Person.name\":\"Feketeová, Linda\"},{\"Person.name\":\"Fedor, Juraj\"},{\"Person.name\":\"Fárník, Michal\"},{\"Person.name\":\"Limão-Vieira, Paulo\"},{\"Person.name\":\"Illenberger, Eugen\"},{\"Person.name\":\"Denifl, Stephan\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | DF – Departamento de Física CeFITec – Centro de Física e Investigação Tecnológica Nature Portfolio RUN |
| datacite.creators.creator.creatorName.fl_str_mv | Meißner, Rebecca Kočišek, Jaroslav Feketeová, Linda Fedor, Juraj Fárník, Michal Limão-Vieira, Paulo Illenberger, Eugen Denifl, Stephan |
| datacite.date.Accepted.fl_str_mv | 2019-12-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2020-09-30T22:22:49Z |
| datacite.date.embargoed.fl_str_mv | 2020-09-30T22:22:49Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | General Chemistry General Biochemistry,Genetics and Molecular Biology General Physics and Astronomy |
| datacite.titles.title.fl_str_mv | Low-energy electrons transform the nimorazole molecule into a radiosensitiser |
| dc.contributor.none.fl_str_mv | DF – Departamento de Física CeFITec – Centro de Física e Investigação Tecnológica Nature Portfolio RUN |
| dc.creator.none.fl_str_mv | Meißner, Rebecca Kočišek, Jaroslav Feketeová, Linda Fedor, Juraj Fárník, Michal Limão-Vieira, Paulo Illenberger, Eugen Denifl, Stephan |
| dc.date.Accepted.fl_str_mv | 2019-12-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2020-09-30T22:22:49Z |
| dc.date.embargoed.fl_str_mv | 2020-09-30T22:22:49Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10362/104982 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | General Chemistry General Biochemistry,Genetics and Molecular Biology General Physics and Astronomy |
| dc.title.fl_str_mv | Low-energy electrons transform the nimorazole molecule into a radiosensitiser |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | While matter is irradiated with highly-energetic particles, it may become chemically modified. Thereby, the reactions of free low-energy electrons (LEEs) formed as secondary particles play an important role. It is unknown to what degree and by which mechanism LEEs contribute to the action of electron-affinic radiosensitisers applied in radiotherapy of hypoxic tumours. Here we show that LEEs effectively cause the reduction of the radiosensitiser nimorazole via associative electron attachment with the cross-section exceeding most of known molecules. This supports the hypothesis that nimorazole is selectively cytotoxic to tumour cells due to reduction of the molecule as prerequisite for accumulation in the cell. In contrast, dissociative electron attachment, commonly believed to be the source of chemical activity of LEEs, represents only a minor reaction channel which is further suppressed upon hydration. Our results show that LEEs may strongly contribute to the radiosensitising effect of nimorazole via associative electron attachment. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://run.unl.pt/bitstreams/86392790-f20f-425b-bef1-4b839b6310c9/download |
| id | run_96816678b290529dfe4e99ffdef4e24f |
| identifier.url.fl_str_mv | http://hdl.handle.net/10362/104982 |
| inst_facet_str | urn:organizationAcronym:unl{{{_:::_}}}Universidade Nova de Lisboa |
| instacron_str | unl |
| institution | Universidade Nova de Lisboa |
| instname_str | Universidade Nova de Lisboa |
| language | eng |
| network_acronym_str | run |
| network_name_str | Repositório Institucional da UNL |
| oai_identifier_str | oai:run.unl.pt:10362/104982 |
| organization_str_mv | urn:organizationAcronym:unl |
| person_str_mv | Meißner, Rebecca Kočišek, Jaroslav Feketeová, Linda Fedor, Juraj Fárník, Michal Limão-Vieira, Paulo Illenberger, Eugen Denifl, Stephan |
| publishDate | 2019 |
| repo_facet_str | urn:repositoryAcronym:run{{{_:::_}}}Repositório Institucional da UNL |
| reponame_str | Repositório Institucional da UNL |
| repository_id_str | urn:repositoryAcronym:run |
| service_str_mv | urn:repositoryAcronym:run |
| spelling | engenWhile matter is irradiated with highly-energetic particles, it may become chemically modified. Thereby, the reactions of free low-energy electrons (LEEs) formed as secondary particles play an important role. It is unknown to what degree and by which mechanism LEEs contribute to the action of electron-affinic radiosensitisers applied in radiotherapy of hypoxic tumours. Here we show that LEEs effectively cause the reduction of the radiosensitiser nimorazole via associative electron attachment with the cross-section exceeding most of known molecules. This supports the hypothesis that nimorazole is selectively cytotoxic to tumour cells due to reduction of the molecule as prerequisite for accumulation in the cell. In contrast, dissociative electron attachment, commonly believed to be the source of chemical activity of LEEs, represents only a minor reaction channel which is further suppressed upon hydration. Our results show that LEEs may strongly contribute to the radiosensitising effect of nimorazole via associative electron attachment.application/pdfenLow-energy electrons transform the nimorazole molecule into a radiosensitiserMeißner, RebeccaKočišek, JaroslavFeketeová, LindaFedor, JurajFárník, MichalLimão-Vieira, PauloIllenberger, EugenDenifl, StephanDF – Departamento de FísicaCeFITec – Centro de Física e Investigação TecnológicaNature PortfolioHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.ptISSNIsPartOf2041-1723URNIsPartOfPURE: 18783922URNIsPartOfPURE UUID: 6b39df2b-c8e6-48f8-82df-8d194188d57aURNIsPartOfScopus: 85067185294URNIsPartOfPubMed: 31160602URNIsPartOfPubMedCentral: PMC6546713URNIsPartOfWOS: 000469909200006URNIsPartOfORCID: /0000-0003-2696-1152/work/151411970DOIIsPartOf10.1038/s41467-019-10340-82020-09-30T22:22:49Z2019-12-012019-12-01T00:00:00ZHandlehttp://hdl.handle.net/10362/104982http://purl.org/coar/access_right/c_abf2open accessGeneral ChemistryGeneral Biochemistry,Genetics and Molecular BiologyGeneral Physics and Astronomy1146401 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/86392790-f20f-425b-bef1-4b839b6310c9/download |
| spellingShingle | Low-energy electrons transform the nimorazole molecule into a radiosensitiser Meißner, Rebecca General Chemistry General Biochemistry,Genetics and Molecular Biology General Physics and Astronomy |
| status | SINGLETON |
| subject.fl_str_mv | General Chemistry General Biochemistry,Genetics and Molecular Biology General Physics and Astronomy |
| title | Low-energy electrons transform the nimorazole molecule into a radiosensitiser |
| title_full | Low-energy electrons transform the nimorazole molecule into a radiosensitiser |
| title_fullStr | Low-energy electrons transform the nimorazole molecule into a radiosensitiser |
| title_full_unstemmed | Low-energy electrons transform the nimorazole molecule into a radiosensitiser |
| title_short | Low-energy electrons transform the nimorazole molecule into a radiosensitiser |
| title_sort | Low-energy electrons transform the nimorazole molecule into a radiosensitiser |
| topic | General Chemistry General Biochemistry,Genetics and Molecular Biology General Physics and Astronomy |
| topic_facet | General Chemistry General Biochemistry,Genetics and Molecular Biology General Physics and Astronomy |
| url | http://hdl.handle.net/10362/104982 |
| visible | 1 |