Publicação
Dry Dosage Forms of Add-Value Bioactive Phenolic Compounds by Supercritical CO2-Assisted Spray-Drying
| Resumo: | Every year, grapevine pruning produces huge amounts of residue, 90% of which are from vine shoots. These are a rich source of natural antioxidants, mostly phenolic compounds, which, when properly extracted, can give rise to added-value products. However, their lack of solubility in aqueous media and high susceptibility to thermal and oxidative degradation highly limit their bioavailability. Encapsulation in suitable carriers may have a positive impact on their bioavailability and bioactivity. Previous data on vine-shoot extraction have identified gallic acid (GA) and resveratrol (RSV) as the main phenolic compounds. In this work, model dry powder formulations (DPFs) of GA and RSV using hydroxypropyl cellulose (HPC) as carriers were developed using Supercritical CO2-Assisted Spray Drying (SASD). A 32 full factorial Design of Experiments investigated the solid and ethanol contents to ascertain process yield, particle size, span, and encapsulation efficiency. Amorphous powder yields above 60%, and encapsulation efficiencies up to 100% were achieved, representing excellent performances. SASD has proven to be an efficient encapsulation technique for these phenolic compounds, preserving their antioxidation potential after three months in storage with average EC50 values of 30.6 µg/mL for GA–DPFs and 149.4 µg/mL for RSV–DPF as assessed by the scavenging capacity of the DPPH radical. |
|---|---|
| Autores principais: | Costa, Clarinda |
| Outros Autores: | Anselmo, Hugo; Ferro, Rita; Matos, Ana Sofia; Aguiar-Ricardo, Ana; Casimiro, Teresa |
| Assunto: | dry powder encapsulation gallic acid hydroxypropyl cellulose quality by design resveratrol Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry |
| Ano: | 2022 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| _version_ | 1868984017514135552 |
|---|---|
| author | Costa, Clarinda |
| author2 | Anselmo, Hugo Ferro, Rita Matos, Ana Sofia Aguiar-Ricardo, Ana Casimiro, Teresa |
| author2_role | author author author author author |
| author_facet | Costa, Clarinda Anselmo, Hugo Ferro, Rita Matos, Ana Sofia Aguiar-Ricardo, Ana Casimiro, Teresa |
| author_role | author |
| contributor_name_str_mv | LAQV@REQUIMTE DQ - Departamento de Química UNIDEMI - Unidade de Investigação e Desenvolvimento em Engenharia Mecânica e Industrial DEMI - Departamento de Engenharia Mecânica e Industrial MDPI - Multidisciplinary Digital Publishing Institute RUN |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Costa, Clarinda\"},{\"Person.name\":\"Anselmo, Hugo\"},{\"Person.name\":\"Ferro, Rita\"},{\"Person.name\":\"Matos, Ana Sofia\"},{\"Person.name\":\"Aguiar-Ricardo, Ana\"},{\"Person.name\":\"Casimiro, Teresa\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | LAQV@REQUIMTE DQ - Departamento de Química UNIDEMI - Unidade de Investigação e Desenvolvimento em Engenharia Mecânica e Industrial DEMI - Departamento de Engenharia Mecânica e Industrial MDPI - Multidisciplinary Digital Publishing Institute RUN |
| datacite.creators.creator.creatorName.fl_str_mv | Costa, Clarinda Anselmo, Hugo Ferro, Rita Matos, Ana Sofia Aguiar-Ricardo, Ana Casimiro, Teresa |
| datacite.date.Accepted.fl_str_mv | 2022-03-20T00:00:00Z |
| datacite.date.available.fl_str_mv | 2022-04-13T22:43:56Z |
| datacite.date.embargoed.fl_str_mv | 2022-04-13T22:43:56Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | dry powder encapsulation gallic acid hydroxypropyl cellulose quality by design resveratrol Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry |
| datacite.titles.title.fl_str_mv | Dry Dosage Forms of Add-Value Bioactive Phenolic Compounds by Supercritical CO2-Assisted Spray-Drying |
| dc.contributor.none.fl_str_mv | LAQV@REQUIMTE DQ - Departamento de Química UNIDEMI - Unidade de Investigação e Desenvolvimento em Engenharia Mecânica e Industrial DEMI - Departamento de Engenharia Mecânica e Industrial MDPI - Multidisciplinary Digital Publishing Institute RUN |
| dc.creator.none.fl_str_mv | Costa, Clarinda Anselmo, Hugo Ferro, Rita Matos, Ana Sofia Aguiar-Ricardo, Ana Casimiro, Teresa |
| dc.date.Accepted.fl_str_mv | 2022-03-20T00:00:00Z |
| dc.date.available.fl_str_mv | 2022-04-13T22:43:56Z |
| dc.date.embargoed.fl_str_mv | 2022-04-13T22:43:56Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10362/136404 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | dry powder encapsulation gallic acid hydroxypropyl cellulose quality by design resveratrol Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry |
| dc.title.fl_str_mv | Dry Dosage Forms of Add-Value Bioactive Phenolic Compounds by Supercritical CO2-Assisted Spray-Drying |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Every year, grapevine pruning produces huge amounts of residue, 90% of which are from vine shoots. These are a rich source of natural antioxidants, mostly phenolic compounds, which, when properly extracted, can give rise to added-value products. However, their lack of solubility in aqueous media and high susceptibility to thermal and oxidative degradation highly limit their bioavailability. Encapsulation in suitable carriers may have a positive impact on their bioavailability and bioactivity. Previous data on vine-shoot extraction have identified gallic acid (GA) and resveratrol (RSV) as the main phenolic compounds. In this work, model dry powder formulations (DPFs) of GA and RSV using hydroxypropyl cellulose (HPC) as carriers were developed using Supercritical CO2-Assisted Spray Drying (SASD). A 32 full factorial Design of Experiments investigated the solid and ethanol contents to ascertain process yield, particle size, span, and encapsulation efficiency. Amorphous powder yields above 60%, and encapsulation efficiencies up to 100% were achieved, representing excellent performances. SASD has proven to be an efficient encapsulation technique for these phenolic compounds, preserving their antioxidation potential after three months in storage with average EC50 values of 30.6 µg/mL for GA–DPFs and 149.4 µg/mL for RSV–DPF as assessed by the scavenging capacity of the DPPH radical. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://run.unl.pt/bitstreams/3ca1eb88-51f2-47a5-b539-a1c44daecf70/download |
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| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia |
| funding.identifier_str_mv | UIDB/50006/2020 UIDP/50006/2020 UIDB/00667/2020 PD/BD/142880/2018 |
| funding.name_str_mv | 6817 - DCRRNI ID 6817 - DCRRNI ID 6817 - DCRRNI ID |
| funding_str_mv | UIDB/50006/2020 info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT UIDP/50006/2020 info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT UIDB/00667/2020 info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00667%2F2020/PT PD/BD/142880/2018 info:eu-repo/grantAgreement/FCT//PD%2FBD%2F142880%2F2018/PT |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10362/136404 |
| inst_facet_str | urn:organizationAcronym:unl{{{_:::_}}}Universidade Nova de Lisboa |
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| institution | Universidade Nova de Lisboa |
| instname_str | Universidade Nova de Lisboa |
| language | eng |
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| network_name_str | Repositório Institucional da UNL |
| oai_identifier_str | oai:run.unl.pt:10362/136404 |
| organization_str_mv | urn:organizationAcronym:unl |
| person_str_mv | Costa, Clarinda Anselmo, Hugo Ferro, Rita Matos, Ana Sofia Aguiar-Ricardo, Ana Casimiro, Teresa |
| publishDate | 2022 |
| repo_facet_str | urn:repositoryAcronym:run{{{_:::_}}}Repositório Institucional da UNL |
| reponame_str | Repositório Institucional da UNL |
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| spelling | engenEvery year, grapevine pruning produces huge amounts of residue, 90% of which are from vine shoots. These are a rich source of natural antioxidants, mostly phenolic compounds, which, when properly extracted, can give rise to added-value products. However, their lack of solubility in aqueous media and high susceptibility to thermal and oxidative degradation highly limit their bioavailability. Encapsulation in suitable carriers may have a positive impact on their bioavailability and bioactivity. Previous data on vine-shoot extraction have identified gallic acid (GA) and resveratrol (RSV) as the main phenolic compounds. In this work, model dry powder formulations (DPFs) of GA and RSV using hydroxypropyl cellulose (HPC) as carriers were developed using Supercritical CO2-Assisted Spray Drying (SASD). A 32 full factorial Design of Experiments investigated the solid and ethanol contents to ascertain process yield, particle size, span, and encapsulation efficiency. Amorphous powder yields above 60%, and encapsulation efficiencies up to 100% were achieved, representing excellent performances. SASD has proven to be an efficient encapsulation technique for these phenolic compounds, preserving their antioxidation potential after three months in storage with average EC50 values of 30.6 µg/mL for GA–DPFs and 149.4 µg/mL for RSV–DPF as assessed by the scavenging capacity of the DPPH radical.application/pdfenDry Dosage Forms of Add-Value Bioactive Phenolic Compounds by Supercritical CO2-Assisted Spray-DryingCosta, ClarindaAnselmo, HugoFerro, RitaMatos, Ana SofiaAguiar-Ricardo, AnaCasimiro, TeresaLAQV@REQUIMTEDQ - Departamento de QuímicaUNIDEMI - Unidade de Investigação e Desenvolvimento em Engenharia Mecânica e IndustrialDEMI - Departamento de Engenharia Mecânica e IndustrialMDPI - Multidisciplinary Digital Publishing InstituteHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.ptISSNIsPartOf1420-3049URNIsPartOfPURE: 43208287URNIsPartOfPURE UUID: 55604162-cb7c-425c-a05b-8160d6dfb65fURNIsPartOfScopus: 85127028862URNIsPartOfPubMed: 35335363URNIsPartOfPubMedCentral: PMC8950927URNIsPartOfWOS: 000774697500001URNIsPartOfORCID: /0000-0002-4659-0275/work/111434233URNIsPartOfORCID: /0000-0002-2193-1440/work/111434263URNIsPartOfORCID: /0000-0001-9405-6221/work/207947340DOIIsPartOf10.3390/molecules270620012022-04-13T22:43:56Z2022-03-202022-03-20T00:00:00ZHandlehttp://hdl.handle.net/10362/136404http://purl.org/coar/access_right/c_abf2open accessdry powderencapsulationgallic acidhydroxypropyl cellulosequality by designresveratrolAnalytical ChemistryChemistry (miscellaneous)Molecular MedicinePharmaceutical ScienceDrug DiscoveryPhysical and Theoretical ChemistryOrganic Chemistry6348721 bytesFundação para a Ciência e a TecnologiaAssociated Laboratory for Green Chemistry - Clean Technologies and Processesinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PTUIDB/50006/20206817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaAssociated Laboratory for Green Chemistry - Clean Technologies and Processesinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PTUIDP/50006/20206817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaResearch and Development Unit for Mechanical and Industrial Engineeringinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00667%2F2020/PTUIDB/00667/20206817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaIntegrated Manufacture of Liposomal Dry Powder Formulationsinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F142880%2F2018/PTPD/BD/142880/2018Crossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/3ca1eb88-51f2-47a5-b539-a1c44daecf70/download |
| spellingShingle | Dry Dosage Forms of Add-Value Bioactive Phenolic Compounds by Supercritical CO2-Assisted Spray-Drying Costa, Clarinda dry powder encapsulation gallic acid hydroxypropyl cellulose quality by design resveratrol Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry |
| status | SINGLETON |
| subject.fl_str_mv | dry powder encapsulation gallic acid hydroxypropyl cellulose quality by design resveratrol Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry |
| title | Dry Dosage Forms of Add-Value Bioactive Phenolic Compounds by Supercritical CO2-Assisted Spray-Drying |
| title_full | Dry Dosage Forms of Add-Value Bioactive Phenolic Compounds by Supercritical CO2-Assisted Spray-Drying |
| title_fullStr | Dry Dosage Forms of Add-Value Bioactive Phenolic Compounds by Supercritical CO2-Assisted Spray-Drying |
| title_full_unstemmed | Dry Dosage Forms of Add-Value Bioactive Phenolic Compounds by Supercritical CO2-Assisted Spray-Drying |
| title_short | Dry Dosage Forms of Add-Value Bioactive Phenolic Compounds by Supercritical CO2-Assisted Spray-Drying |
| title_sort | Dry Dosage Forms of Add-Value Bioactive Phenolic Compounds by Supercritical CO2-Assisted Spray-Drying |
| topic | dry powder encapsulation gallic acid hydroxypropyl cellulose quality by design resveratrol Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry |
| topic_facet | dry powder encapsulation gallic acid hydroxypropyl cellulose quality by design resveratrol Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Pharmaceutical Science Drug Discovery Physical and Theoretical Chemistry Organic Chemistry |
| url | http://hdl.handle.net/10362/136404 |
| visible | 1 |
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