Publicação
Gene Regulation by the transcription factor ZEB1 in Glioblastoma Multiforme
| Resumo: | Glioblastoma Multiforme (GBM) is the most prevalent type of glioma, bearing the highest incidence rate of brain and Central Nervous System (CNS) malignant tumors and the lowest survival rate. GBMs distinguish themselves from lower grade glial tumors by the presence of certain hallmark histological features such as the presence of central necrosis in the tumor mass, marginal proliferation of endothelial cells and the presence of palisading cells around the area of necrosis. Several hallmark features contribute to the poor responsiveness that GBM tumors have to treatment including their high inter- and intratumoral heterogeneity at a phenotypic, cellular, genetic and epigenetic level. Most importantly, the existence of cancer stem cell (CSC) populations within GBM tumors is crucial for driving invasive tumor growth due to their potential to proliferate in vascular conditions, while becoming highly invasive in hypoxic conditions. Moreover, the ability of GBM CSCs to infiltrate surrounding brain parenchyma means that even the smallest number of such cells left after surgery will cause tumor recurrence.(...) |
|---|---|
| Autores principais: | Rosmaninho, Pedro |
| Assunto: | Molecular Biology |
| Ano: | 2016 |
| País: | Portugal |
| Tipo de documento: | tese de doutoramento |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| _version_ | 1868983246294876160 |
|---|---|
| author | Rosmaninho, Pedro |
| author_facet | Rosmaninho, Pedro |
| author_role | author |
| contributor_name_str_mv | Castro, Diogo RUN |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Rosmaninho, Pedro\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Castro, Diogo RUN |
| datacite.creators.creator.creatorName.fl_str_mv | Rosmaninho, Pedro |
| datacite.date.Accepted.fl_str_mv | 2016-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2019-01-07T17:33:58Z |
| datacite.date.embargoed.fl_str_mv | 2019-01-07T17:33:58Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Molecular Biology |
| datacite.titles.title.fl_str_mv | Gene Regulation by the transcription factor ZEB1 in Glioblastoma Multiforme |
| dc.contributor.none.fl_str_mv | Castro, Diogo RUN |
| dc.creator.none.fl_str_mv | Rosmaninho, Pedro |
| dc.date.Accepted.fl_str_mv | 2016-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2019-01-07T17:33:58Z |
| dc.date.embargoed.fl_str_mv | 2019-01-07T17:33:58Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10362/56697 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Molecular Biology |
| dc.title.fl_str_mv | Gene Regulation by the transcription factor ZEB1 in Glioblastoma Multiforme |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_db06 |
| description | Glioblastoma Multiforme (GBM) is the most prevalent type of glioma, bearing the highest incidence rate of brain and Central Nervous System (CNS) malignant tumors and the lowest survival rate. GBMs distinguish themselves from lower grade glial tumors by the presence of certain hallmark histological features such as the presence of central necrosis in the tumor mass, marginal proliferation of endothelial cells and the presence of palisading cells around the area of necrosis. Several hallmark features contribute to the poor responsiveness that GBM tumors have to treatment including their high inter- and intratumoral heterogeneity at a phenotypic, cellular, genetic and epigenetic level. Most importantly, the existence of cancer stem cell (CSC) populations within GBM tumors is crucial for driving invasive tumor growth due to their potential to proliferate in vascular conditions, while becoming highly invasive in hypoxic conditions. Moreover, the ability of GBM CSCs to infiltrate surrounding brain parenchyma means that even the smallest number of such cells left after surgery will cause tumor recurrence.(...) |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | doctoralThesis |
| fulltext.url.fl_str_mv | https://run.unl.pt/bitstreams/0eba2411-2546-4b2b-b26e-b15f71e08cb8/download |
| id | run_a86dfa9da19e2022affba2a2dfd0ac7e |
| identifier.url.fl_str_mv | http://hdl.handle.net/10362/56697 |
| inst_facet_str | urn:organizationAcronym:unl{{{_:::_}}}Universidade Nova de Lisboa |
| instacron_str | unl |
| institution | Universidade Nova de Lisboa |
| instname_str | Universidade Nova de Lisboa |
| language | eng |
| network_acronym_str | run |
| network_name_str | Repositório Institucional da UNL |
| oai_identifier_str | oai:run.unl.pt:10362/56697 |
| organization_str_mv | urn:organizationAcronym:unl |
| person_str_mv | Rosmaninho, Pedro |
| publishDate | 2016 |
| repo_facet_str | urn:repositoryAcronym:run{{{_:::_}}}Repositório Institucional da UNL |
| reponame_str | Repositório Institucional da UNL |
| repository_id_str | urn:repositoryAcronym:run |
| service_str_mv | urn:repositoryAcronym:run |
| spelling | engpt_PTGlioblastoma Multiforme (GBM) is the most prevalent type of glioma, bearing the highest incidence rate of brain and Central Nervous System (CNS) malignant tumors and the lowest survival rate. GBMs distinguish themselves from lower grade glial tumors by the presence of certain hallmark histological features such as the presence of central necrosis in the tumor mass, marginal proliferation of endothelial cells and the presence of palisading cells around the area of necrosis. Several hallmark features contribute to the poor responsiveness that GBM tumors have to treatment including their high inter- and intratumoral heterogeneity at a phenotypic, cellular, genetic and epigenetic level. Most importantly, the existence of cancer stem cell (CSC) populations within GBM tumors is crucial for driving invasive tumor growth due to their potential to proliferate in vascular conditions, while becoming highly invasive in hypoxic conditions. Moreover, the ability of GBM CSCs to infiltrate surrounding brain parenchyma means that even the smallest number of such cells left after surgery will cause tumor recurrence.(...)application/pdfpt_PTGene Regulation by the transcription factor ZEB1 in Glioblastoma MultiformeRosmaninho, PedroCastro, DiogoHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.pt2019-01-07T17:33:58Z20162016-102016-01-01T00:00:00ZHandlehttp://hdl.handle.net/10362/56697http://purl.org/coar/access_right/c_abf2open accessMolecular Biology6342210 bytesliteraturehttp://purl.org/coar/resource_type/c_db06doctoral thesis2016http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/0eba2411-2546-4b2b-b26e-b15f71e08cb8/download |
| spellingShingle | Gene Regulation by the transcription factor ZEB1 in Glioblastoma Multiforme Rosmaninho, Pedro Molecular Biology |
| status | SINGLETON |
| subject.fl_str_mv | Molecular Biology |
| title | Gene Regulation by the transcription factor ZEB1 in Glioblastoma Multiforme |
| title_full | Gene Regulation by the transcription factor ZEB1 in Glioblastoma Multiforme |
| title_fullStr | Gene Regulation by the transcription factor ZEB1 in Glioblastoma Multiforme |
| title_full_unstemmed | Gene Regulation by the transcription factor ZEB1 in Glioblastoma Multiforme |
| title_short | Gene Regulation by the transcription factor ZEB1 in Glioblastoma Multiforme |
| title_sort | Gene Regulation by the transcription factor ZEB1 in Glioblastoma Multiforme |
| topic | Molecular Biology |
| topic_facet | Molecular Biology |
| url | http://hdl.handle.net/10362/56697 |
| visible | 1 |