Publicação
How to distinguish promotion, prevention, and treatment trials in public mental health
| Resumo: | Background. Promoting mental health, preventing mental disorders and providing effective treatments are public health priorities. Randomized controlled trials (RCTs) frequently evaluate mental health and psychosocial support interventions to achieve one or more of these objectives. Distinguishing between RCTs focused on mental health promotion, prevention or treatment remains conceptually and methodologically challenging. No standardized tool exists to position RCTs along a promotion-to-treatment continuum in mental health. We aimed to develop and validate the VErona-LUgano Tool (VELUT) for distinguishing RCTs along the promotion-to-treatment continuum. Methods. An interdisciplinary tool development group (TDG) was established. The Population, Intervention, Comparison and Outcome framework was used to define key constructs. Items in the tool were devised, categorized and reduced through qualitative and quantitative methods. Finally, we performed a preliminary validation of the VELUT applying item response theory (IRT) using data from 180 RCTs. Results. The TDG generated 33 items for the initial version of the VELUT, reduced to 16 through review, cognitive interviews and psychometric analysis. Analyses of 180 RCTs using the 16-item tool showed high internal consistency (α = 0.94) and unidimensionality. Following item reduction and IRT, a final 8-item version was retained, and IRT models confirmed strong item discrimination for the 8 items and high scale reliability (marginal reliability >0.90 across most of the range of the scale), good response distribution, item performance and alignment with the Institute of Medicine (IOM) promotion-to-treatment continuum. Conclusions. The VELUT addresses methodological gaps in global mental health research by helping to position RCTs of MHPSS interventions along the IOM promotion-to-treatment continuum. |
|---|---|
| Autores principais: | Purgato, Marianna |
| Outros Autores: | Albanese, Emiliano; Gross, Alden L.; Annoni, Anna Maria; Acarturk, Ceren; Cadorin, Camilla; Jordans, Mark J.D.; Lund, Crick; Papola, Davide; Prina, Eleonora; Sijbrandij, Marit; Silva, Manuela; Silva, Manuela; Tedeschi, Federico; Tol, Wietse A.; Barbui, Corrado |
| Assunto: | evidence synthesis item response theory mental health prevention promotion Epidemiology Public Health, Environmental and Occupational Health Psychiatry and Mental health SDG 3 - Good Health and Well-being |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| _version_ | 1868982786628517888 |
|---|---|
| author | Purgato, Marianna |
| author2 | Albanese, Emiliano Gross, Alden L. Annoni, Anna Maria Acarturk, Ceren Cadorin, Camilla Jordans, Mark J.D. Lund, Crick Papola, Davide Prina, Eleonora Sijbrandij, Marit Silva, Manuela Silva, Manuela Tedeschi, Federico Tol, Wietse A. Barbui, Corrado |
| author2_role | author author author author author author author author author author author author author author author |
| author_facet | Purgato, Marianna Albanese, Emiliano Gross, Alden L. Annoni, Anna Maria Acarturk, Ceren Cadorin, Camilla Jordans, Mark J.D. Lund, Crick Papola, Davide Prina, Eleonora Sijbrandij, Marit Silva, Manuela Silva, Manuela Tedeschi, Federico Tol, Wietse A. Barbui, Corrado |
| author_role | author |
| contributor_name_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Comprehensive Health Research Centre (CHRC) - pólo NMS Cambridge University Press RUN |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Purgato, Marianna\"},{\"Person.name\":\"Albanese, Emiliano\"},{\"Person.name\":\"Gross, Alden L.\"},{\"Person.name\":\"Annoni, Anna Maria\"},{\"Person.name\":\"Acarturk, Ceren\"},{\"Person.name\":\"Cadorin, Camilla\"},{\"Person.name\":\"Jordans, Mark J.D.\"},{\"Person.name\":\"Lund, Crick\"},{\"Person.name\":\"Papola, Davide\"},{\"Person.name\":\"Prina, Eleonora\"},{\"Person.name\":\"Sijbrandij, Marit\"},{\"Person.name\":\"Silva, Manuela\"},{\"Person.name\":\"Silva, Manuela\",\"Person.identifier.orcid\":\"0000-0003-1275-0338\"},{\"Person.name\":\"Tedeschi, Federico\"},{\"Person.name\":\"Tol, Wietse A.\"},{\"Person.name\":\"Barbui, Corrado\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Comprehensive Health Research Centre (CHRC) - pólo NMS Cambridge University Press RUN |
| datacite.creators.creator.creatorName.fl_str_mv | Purgato, Marianna Albanese, Emiliano Gross, Alden L. Annoni, Anna Maria Acarturk, Ceren Cadorin, Camilla Jordans, Mark J.D. Lund, Crick Papola, Davide Prina, Eleonora Sijbrandij, Marit Silva, Manuela Silva, Manuela Tedeschi, Federico Tol, Wietse A. Barbui, Corrado |
| datacite.date.Accepted.fl_str_mv | 2025-11-12T00:00:00Z |
| datacite.date.available.fl_str_mv | 2025-12-05T21:16:01Z |
| datacite.date.embargoed.fl_str_mv | 2025-12-05T21:16:01Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | evidence synthesis item response theory mental health prevention promotion Epidemiology Public Health, Environmental and Occupational Health Psychiatry and Mental health SDG 3 - Good Health and Well-being |
| datacite.titles.title.fl_str_mv | How to distinguish promotion, prevention, and treatment trials in public mental health development and validation of the VErona-LUgano Tool (VELUT) |
| dc.contributor.none.fl_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Comprehensive Health Research Centre (CHRC) - pólo NMS Cambridge University Press RUN |
| dc.creator.none.fl_str_mv | Purgato, Marianna Albanese, Emiliano Gross, Alden L. Annoni, Anna Maria Acarturk, Ceren Cadorin, Camilla Jordans, Mark J.D. Lund, Crick Papola, Davide Prina, Eleonora Sijbrandij, Marit Silva, Manuela Silva, Manuela Tedeschi, Federico Tol, Wietse A. Barbui, Corrado |
| dc.date.Accepted.fl_str_mv | 2025-11-12T00:00:00Z |
| dc.date.available.fl_str_mv | 2025-12-05T21:16:01Z |
| dc.date.embargoed.fl_str_mv | 2025-12-05T21:16:01Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10362/191561 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | evidence synthesis item response theory mental health prevention promotion Epidemiology Public Health, Environmental and Occupational Health Psychiatry and Mental health SDG 3 - Good Health and Well-being |
| dc.title.fl_str_mv | How to distinguish promotion, prevention, and treatment trials in public mental health development and validation of the VErona-LUgano Tool (VELUT) |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Background. Promoting mental health, preventing mental disorders and providing effective treatments are public health priorities. Randomized controlled trials (RCTs) frequently evaluate mental health and psychosocial support interventions to achieve one or more of these objectives. Distinguishing between RCTs focused on mental health promotion, prevention or treatment remains conceptually and methodologically challenging. No standardized tool exists to position RCTs along a promotion-to-treatment continuum in mental health. We aimed to develop and validate the VErona-LUgano Tool (VELUT) for distinguishing RCTs along the promotion-to-treatment continuum. Methods. An interdisciplinary tool development group (TDG) was established. The Population, Intervention, Comparison and Outcome framework was used to define key constructs. Items in the tool were devised, categorized and reduced through qualitative and quantitative methods. Finally, we performed a preliminary validation of the VELUT applying item response theory (IRT) using data from 180 RCTs. Results. The TDG generated 33 items for the initial version of the VELUT, reduced to 16 through review, cognitive interviews and psychometric analysis. Analyses of 180 RCTs using the 16-item tool showed high internal consistency (α = 0.94) and unidimensionality. Following item reduction and IRT, a final 8-item version was retained, and IRT models confirmed strong item discrimination for the 8 items and high scale reliability (marginal reliability >0.90 across most of the range of the scale), good response distribution, item performance and alignment with the Institute of Medicine (IOM) promotion-to-treatment continuum. Conclusions. The VELUT addresses methodological gaps in global mental health research by helping to position RCTs of MHPSS interventions along the IOM promotion-to-treatment continuum. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://run.unl.pt/bitstreams/f579b23f-dd45-4320-859a-e05753e7d828/download |
| id | run_bb536b85c0fda053fa18cdcd96894faf |
| identifier.url.fl_str_mv | http://hdl.handle.net/10362/191561 |
| inst_facet_str | urn:organizationAcronym:unl{{{_:::_}}}Universidade Nova de Lisboa |
| instacron_str | unl |
| institution | Universidade Nova de Lisboa |
| instname_str | Universidade Nova de Lisboa |
| language | eng |
| network_acronym_str | run |
| network_name_str | Repositório Institucional da UNL |
| oai_identifier_str | oai:run.unl.pt:10362/191561 |
| organization_str_mv | urn:organizationAcronym:unl |
| person_str_mv | Purgato, Marianna Albanese, Emiliano Gross, Alden L. Annoni, Anna Maria Acarturk, Ceren Cadorin, Camilla Jordans, Mark J.D. Lund, Crick Papola, Davide Prina, Eleonora Sijbrandij, Marit Silva, Manuela Silva, Manuela Silva, Manuela https://www.ciencia-id.pt/3611-0846-4053 3611-0846-4053 http://orcid.org/0000-0003-1275-0338 0000-0003-1275-0338 Tedeschi, Federico Tol, Wietse A. Barbui, Corrado |
| publishDate | 2025 |
| repo_facet_str | urn:repositoryAcronym:run{{{_:::_}}}Repositório Institucional da UNL |
| reponame_str | Repositório Institucional da UNL |
| repository_id_str | urn:repositoryAcronym:run |
| service_str_mv | urn:repositoryAcronym:run |
| spelling | engenBackground. Promoting mental health, preventing mental disorders and providing effective treatments are public health priorities. Randomized controlled trials (RCTs) frequently evaluate mental health and psychosocial support interventions to achieve one or more of these objectives. Distinguishing between RCTs focused on mental health promotion, prevention or treatment remains conceptually and methodologically challenging. No standardized tool exists to position RCTs along a promotion-to-treatment continuum in mental health. We aimed to develop and validate the VErona-LUgano Tool (VELUT) for distinguishing RCTs along the promotion-to-treatment continuum. Methods. An interdisciplinary tool development group (TDG) was established. The Population, Intervention, Comparison and Outcome framework was used to define key constructs. Items in the tool were devised, categorized and reduced through qualitative and quantitative methods. Finally, we performed a preliminary validation of the VELUT applying item response theory (IRT) using data from 180 RCTs. Results. The TDG generated 33 items for the initial version of the VELUT, reduced to 16 through review, cognitive interviews and psychometric analysis. Analyses of 180 RCTs using the 16-item tool showed high internal consistency (α = 0.94) and unidimensionality. Following item reduction and IRT, a final 8-item version was retained, and IRT models confirmed strong item discrimination for the 8 items and high scale reliability (marginal reliability >0.90 across most of the range of the scale), good response distribution, item performance and alignment with the Institute of Medicine (IOM) promotion-to-treatment continuum. Conclusions. The VELUT addresses methodological gaps in global mental health research by helping to position RCTs of MHPSS interventions along the IOM promotion-to-treatment continuum.application/pdfenHow to distinguish promotion, prevention, and treatment trials in public mental healthSubtitleendevelopment and validation of the VErona-LUgano Tool (VELUT)Purgato, MariannaAlbanese, EmilianoGross, Alden L.Annoni, Anna MariaAcarturk, CerenCadorin, CamillaJordans, Mark J.D.Lund, CrickPapola, DavidePrina, EleonoraSijbrandij, MaritSilva, ManuelaPersonalSilva, ManuelaDSpacehttp://dspace.org/items/56492782-3e53-42d0-94d2-a737b64d8c9dDSpacehttp://dspace.org/items/56492782-3e53-42d0-94d2-a737b64d8c9dSilvaManuelaCiência IDhttps://www.ciencia-id.pt3611-0846-4053ORCIDhttp://orcid.org0000-0003-1275-0338Scopus Author IDhttps://www.scopus.com57193072503Tedeschi, FedericoTol, Wietse A.Barbui, CorradoNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSCambridge University PressHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.ptISSNIsPartOf2045-7960URNIsPartOfPURE: 136264337URNIsPartOfPURE UUID: 66cd92a0-7566-4177-a13e-4507a3495f37URNIsPartOfScopus: 105021461604URNIsPartOfPubMed: 41221807DOIIsPartOf10.1017/S20457960251002802025-12-05T21:16:01Z2025-11-122025-11-12T00:00:00ZHandlehttp://hdl.handle.net/10362/191561http://purl.org/coar/access_right/c_abf2open accessevidence synthesisitem response theorymental healthpreventionpromotionEpidemiologyPublic Health, Environmental and Occupational HealthPsychiatry and Mental healthSDG 3 - Good Health and Well-being1264770 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/f579b23f-dd45-4320-859a-e05753e7d828/download |
| spellingShingle | How to distinguish promotion, prevention, and treatment trials in public mental health Purgato, Marianna evidence synthesis item response theory mental health prevention promotion Epidemiology Public Health, Environmental and Occupational Health Psychiatry and Mental health SDG 3 - Good Health and Well-being |
| status | SINGLETON |
| subject.fl_str_mv | evidence synthesis item response theory mental health prevention promotion Epidemiology Public Health, Environmental and Occupational Health Psychiatry and Mental health SDG 3 - Good Health and Well-being |
| title | How to distinguish promotion, prevention, and treatment trials in public mental health |
| title_full | How to distinguish promotion, prevention, and treatment trials in public mental health |
| title_fullStr | How to distinguish promotion, prevention, and treatment trials in public mental health |
| title_full_unstemmed | How to distinguish promotion, prevention, and treatment trials in public mental health |
| title_short | How to distinguish promotion, prevention, and treatment trials in public mental health |
| title_sort | How to distinguish promotion, prevention, and treatment trials in public mental health |
| topic | evidence synthesis item response theory mental health prevention promotion Epidemiology Public Health, Environmental and Occupational Health Psychiatry and Mental health SDG 3 - Good Health and Well-being |
| topic_facet | evidence synthesis item response theory mental health prevention promotion Epidemiology Public Health, Environmental and Occupational Health Psychiatry and Mental health SDG 3 - Good Health and Well-being |
| url | http://hdl.handle.net/10362/191561 |
| visible | 1 |