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Insulin

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Resumo:Kidney function in metabolism is often underestimated. Although the word “clearance” is associated to “degradation”, at nephron level, proper balance between what is truly degraded and what is redirected to de novo utilization is crucial for the maintenance of electrolytic and acid–basic balance and energy conservation. Insulin is probably one of the best examples of how diverse and heterogeneous kidney response can be. Kidney has a primary role in the degradation of insulin released in the bloodstream, but it is also incredibly susceptible to insulin action throughout the nephron. Fluctuations in insulin levels during fast and fed state add another layer of complexity in the understanding of kidney fine-tuning. This review aims at revisiting renal insulin actions and clearance and to address the association of kidney dysmetabolism with hyperinsulinemia and insulin resistance, both highly prevalent phenomena in modern society.
Autores principais:Pina, Ana F.
Outros Autores:Borges, Diego O.; Meneses, Maria João; Branco, Patrícia; Birne, Rita; Vilasi, Antonio; Macedo, Maria Paula
Assunto:albuminuria diabetic nephropathy insulin insulin clearance insulin resistance Developmental Biology Cell Biology SDG 3 - Good Health and Well-being SDG 7 - Affordable and Clean Energy
Ano:2020
País:Portugal
Tipo de documento:recensão
Tipo de acesso:acesso aberto
Instituição associada:Universidade Nova de Lisboa
Idioma:inglês
Origem:Repositório Institucional da UNL

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