Publicação
An application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sites
| Resumo: | Chromosomal fragile sites (CFSs) are loci or regions susceptible to spontaneous or induced occurrence of breaks and rearrangements. They are classified in two main categories, rare and common, depending on their frequency in the population. In order to identify which CFSs are influential or significant in the occurrence of deletions and duplications (chromosomal constitutional imbalances), we propose a logistic regression analysis for the CFS data set, since the underlying response variable is categorical, specifically binary (deletion or duplication). Some results are presented here as an informative preliminary contribution to understand the frailty of these CFS in increasing/decreasing of the deletion odds. This study has implications for our comprehension of human pathogenesis. |
|---|---|
| Autores principais: | Silva, Giovani L. |
| Outros Autores: | Sequeira, Inês J.; Gomes, D. Prata; Rueff, José; Brás, Aldina |
| Assunto: | Chromosomal fragile sites deletions duplications logistic regression model Statistics, Probability and Uncertainty Statistics and Probability |
| Ano: | 2024 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| _version_ | 1868984256214073344 |
|---|---|
| author | Silva, Giovani L. |
| author2 | Sequeira, Inês J. Gomes, D. Prata Rueff, José Brás, Aldina |
| author2_role | author author author author |
| author_facet | Silva, Giovani L. Sequeira, Inês J. Gomes, D. Prata Rueff, José Brás, Aldina |
| author_role | author |
| contributor_name_str_mv | CMA - Centro de Matemática e Aplicações DM - Departamento de Matemática Faculdade de Ciências e Tecnologia (FCT) Centre for Toxicogenomics and Human Health (ToxOmics) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Taylor & Francis RUN |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Silva, Giovani L.\"},{\"Person.name\":\"Sequeira, Inês J.\"},{\"Person.name\":\"Gomes, D. Prata\"},{\"Person.name\":\"Rueff, José\"},{\"Person.name\":\"Brás, Aldina\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | CMA - Centro de Matemática e Aplicações DM - Departamento de Matemática Faculdade de Ciências e Tecnologia (FCT) Centre for Toxicogenomics and Human Health (ToxOmics) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Taylor & Francis RUN |
| datacite.creators.creator.creatorName.fl_str_mv | Silva, Giovani L. Sequeira, Inês J. Gomes, D. Prata Rueff, José Brás, Aldina |
| datacite.date.Accepted.fl_str_mv | 2024-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2026-03-31T12:53:01Z |
| datacite.date.embargoed.fl_str_mv | 2026-03-31T12:53:01Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Chromosomal fragile sites deletions duplications logistic regression model Statistics, Probability and Uncertainty Statistics and Probability |
| datacite.titles.title.fl_str_mv | An application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sites |
| dc.contributor.none.fl_str_mv | CMA - Centro de Matemática e Aplicações DM - Departamento de Matemática Faculdade de Ciências e Tecnologia (FCT) Centre for Toxicogenomics and Human Health (ToxOmics) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Taylor & Francis RUN |
| dc.creator.none.fl_str_mv | Silva, Giovani L. Sequeira, Inês J. Gomes, D. Prata Rueff, José Brás, Aldina |
| dc.date.Accepted.fl_str_mv | 2024-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2026-03-31T12:53:01Z |
| dc.date.embargoed.fl_str_mv | 2026-03-31T12:53:01Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10362/201947 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Chromosomal fragile sites deletions duplications logistic regression model Statistics, Probability and Uncertainty Statistics and Probability |
| dc.title.fl_str_mv | An application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sites |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Chromosomal fragile sites (CFSs) are loci or regions susceptible to spontaneous or induced occurrence of breaks and rearrangements. They are classified in two main categories, rare and common, depending on their frequency in the population. In order to identify which CFSs are influential or significant in the occurrence of deletions and duplications (chromosomal constitutional imbalances), we propose a logistic regression analysis for the CFS data set, since the underlying response variable is categorical, specifically binary (deletion or duplication). Some results are presented here as an informative preliminary contribution to understand the frailty of these CFS in increasing/decreasing of the deletion odds. This study has implications for our comprehension of human pathogenesis. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://run.unl.pt/bitstreams/c6a234d2-f790-4f9a-b2f8-7a61232f3216/download |
| id | run_bd9ec4e1bd770fbd1b112ae209c8e796 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10362/201947 |
| inst_facet_str | urn:organizationAcronym:unl{{{_:::_}}}Universidade Nova de Lisboa |
| instacron_str | unl |
| institution | Universidade Nova de Lisboa |
| instname_str | Universidade Nova de Lisboa |
| language | eng |
| network_acronym_str | run |
| network_name_str | Repositório Institucional da UNL |
| oai_identifier_str | oai:run.unl.pt:10362/201947 |
| organization_str_mv | urn:organizationAcronym:unl |
| person_str_mv | Silva, Giovani L. Sequeira, Inês J. Gomes, D. Prata Rueff, José Brás, Aldina |
| publishDate | 2024 |
| repo_facet_str | urn:repositoryAcronym:run{{{_:::_}}}Repositório Institucional da UNL |
| reponame_str | Repositório Institucional da UNL |
| repository_id_str | urn:repositoryAcronym:run |
| service_str_mv | urn:repositoryAcronym:run |
| spelling | engenChromosomal fragile sites (CFSs) are loci or regions susceptible to spontaneous or induced occurrence of breaks and rearrangements. They are classified in two main categories, rare and common, depending on their frequency in the population. In order to identify which CFSs are influential or significant in the occurrence of deletions and duplications (chromosomal constitutional imbalances), we propose a logistic regression analysis for the CFS data set, since the underlying response variable is categorical, specifically binary (deletion or duplication). Some results are presented here as an informative preliminary contribution to understand the frailty of these CFS in increasing/decreasing of the deletion odds. This study has implications for our comprehension of human pathogenesis.application/pdfenAn application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sitesSilva, Giovani L.Sequeira, Inês J.Gomes, D. PrataRueff, JoséBrás, AldinaCMA - Centro de Matemática e AplicaçõesDM - Departamento de MatemáticaFaculdade de Ciências e Tecnologia (FCT)Centre for Toxicogenomics and Human Health (ToxOmics)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Taylor & FrancisHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.ptISSNIsPartOf2768-4520URNIsPartOfPURE: 159242251URNIsPartOfPURE UUID: 8dc63e06-148a-419e-8f82-99e31169fa11URNIsPartOfScopus: 105018755188URNIsPartOfORCID: /0000-0002-5165-2346/work/210364222DOIIsPartOf10.1080/27684520.2024.23311102026-03-31T12:53:01Z20242024-01-01T00:00:00ZHandlehttp://hdl.handle.net/10362/201947http://purl.org/coar/access_right/c_abf2open accessChromosomal fragile sitesdeletionsduplicationslogistic regression modelStatistics, Probability and UncertaintyStatistics and Probability2386018 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/c6a234d2-f790-4f9a-b2f8-7a61232f3216/download |
| spellingShingle | An application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sites Silva, Giovani L. Chromosomal fragile sites deletions duplications logistic regression model Statistics, Probability and Uncertainty Statistics and Probability |
| status | SINGLETON |
| subject.fl_str_mv | Chromosomal fragile sites deletions duplications logistic regression model Statistics, Probability and Uncertainty Statistics and Probability |
| title | An application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sites |
| title_full | An application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sites |
| title_fullStr | An application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sites |
| title_full_unstemmed | An application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sites |
| title_short | An application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sites |
| title_sort | An application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sites |
| topic | Chromosomal fragile sites deletions duplications logistic regression model Statistics, Probability and Uncertainty Statistics and Probability |
| topic_facet | Chromosomal fragile sites deletions duplications logistic regression model Statistics, Probability and Uncertainty Statistics and Probability |
| url | http://hdl.handle.net/10362/201947 |
| visible | 1 |