Publicação

An application of logistic regression model to the study of constitutional imbalances in human chromosomal fragile sites

Ver documento

Detalhes bibliográficos
Resumo:Chromosomal fragile sites (CFSs) are loci or regions susceptible to spontaneous or induced occurrence of breaks and rearrangements. They are classified in two main categories, rare and common, depending on their frequency in the population. In order to identify which CFSs are influential or significant in the occurrence of deletions and duplications (chromosomal constitutional imbalances), we propose a logistic regression analysis for the CFS data set, since the underlying response variable is categorical, specifically binary (deletion or duplication). Some results are presented here as an informative preliminary contribution to understand the frailty of these CFS in increasing/decreasing of the deletion odds. This study has implications for our comprehension of human pathogenesis.
Autores principais:Silva, Giovani L.
Outros Autores:Sequeira, Inês J.; Gomes, D. Prata; Rueff, José; Brás, Aldina
Assunto:Chromosomal fragile sites deletions duplications logistic regression model Statistics, Probability and Uncertainty Statistics and Probability
Ano:2024
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Universidade Nova de Lisboa
Idioma:inglês
Origem:Repositório Institucional da UNL

Registos relacionados

Registos relacionados