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Sperm telomere length in patients undergoing infertility treatments: prospective study

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Resumo:In recent years, studies have demonstrated the shortening of sperm telomeres (STL) in infertile patients, which has been associated with decreased chromatin concentration and compaction, increased DNA fragmentation (sDNAfrag) and aneuploidy in sperm. However, there are studies that contradict these observations. The main purpose of this project was to clarify whether STL is related to sperm quality and its clinical outcomes. For that, we evaluated the STL of patients undergoing infertility treatments and analyzed its relationship with all the seminal parameters, chromatin maturity, sDNAfrag, aneuploidies and oxidative profile, as well as the clinical parameters after the treatments, using swim-up purified spermatozoa. No statistically significant differences were observed in relation to the seminal parameters in the population of purified spermatozoa, suggesting the importance of this method of selection for clinical use. Another original aspect was the observation that the population with the highest STL is reduced, but it has a higher rate of pregnancy (40%), and that the majority of the population is located in an STL range in which the rate of pregnancy is lower (29 %). In future studies we intend to increase the sample size to consolidate the obtained results and to complement them with additional methods.
Autores principais:Lopes, Ana Catarina Vieira
Assunto:sperm telomeres human reproduction male infertility assisted reproductive technology
Ano:2018
País:Portugal
Tipo de documento:dissertação de mestrado
Tipo de acesso:acesso aberto
Instituição associada:Universidade Nova de Lisboa
Idioma:inglês
Origem:Repositório Institucional da UNL

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