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Nanoparticles for recognition and delivery in metastatic colorectal cancer cells

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Resumo:"Colorectal cancer is a global health concern. The high incidence of colorectal metastasis, mainly in the liver, triggers an increase of the mortality rate and greatly reduces the effective cure chances. For this reason, the investigation in the area is now focused on efficient detection and elimination of metastasis. Nanotechnology has become a fundamental research field since it provides promising perspectives regarding specific, oriented and sustained delivery of loaded nanoparticles for nanoteragnostic approaches. The current project aims to develop a nanocarrier, strategically constructed for specific administration, recognition and therapy of colorectal liver metastasis. Concerning this goal, two different approaches were concurrently developed: a green-therapeutic technology and a novel nanoparticulate system, by nanoprecipitation and inverse microemulsion, respectively. (…)"
Autores principais:Roda, Ana Sofia Martins
Assunto:metastatic colorectal cancer polymeric nanoparticles drug delivery mPEG-co-PCL chitosan collagenase
Ano:2016
País:Portugal
Tipo de documento:dissertação de mestrado
Tipo de acesso:acesso aberto
Instituição associada:Universidade Nova de Lisboa
Idioma:inglês
Origem:Repositório Institucional da UNL

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