Publicação

IgG+ Extracellular Vesicles Measure Therapeutic Response in Advanced Pancreatic Cancer

Ver documento

Detalhes bibliográficos
Resumo:(1) Background: Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second-leading cause of cancer deaths by 2030. Imaging techniques are the standard for monitoring the therapy response in PDAC, but these techniques have considerable limits, including delayed disease progression detection and difficulty in distinguishing benign from malignant lesions. Extracellular vesicle (EV) liquid biopsy is an emerging diagnosis modality. Nonetheless, the majority of research for EV-based diagnosis relies on point analyses of EVs at specified times, while longitudinal EV population studies before and during therapeutic interventions remain largely unexplored. (2) Methods: We analyzed plasma EV protein composition at diagnosis and throughout PDAC therapy. (3) Results: We found that IgG is linked with the diagnosis of PDAC and the patient’s response to therapy, and that the IgG+ EV population increases with disease progression and reduces with treatment response. Importantly, this covers PDAC patients devoid of the standard PDAC seric marker CA19.9 expression. We also observed that IgG is bound to EVs via the tumor antigen MAGE B1, and that this is independent of the patient’s inflammatory condition and IgG seric levels. (4) Conclusions: We here propose that a population analysis of IgG+ EVs in PDAC plasma represents a novel method to supplement the monitoring of the PDAC treatment response.
Autores principais:Couto, Nuno
Outros Autores:Elzanowska, Julia; Maia, Joana; Batista, Silvia; Pereira, Catarina Esteves; Beck, Hans Christian; Carvalho, Ana Sofia; Strano Moraes, Maria Carolina; Carvalho, Carlos; Oliveira, Manuela; Matthiesen, Rune; Matthiesen, Rune; Costa-Silva, Bruno
Assunto:biomarker extracellular vesicles IgG liquid biopsy pancreatic cancer General Biochemistry,Genetics and Molecular Biology SDG 3 - Good Health and Well-being
Ano:2022
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Universidade Nova de Lisboa
Idioma:inglês
Origem:Repositório Institucional da UNL

Registos relacionados

Registos relacionados