Publicação
Influence of the pH Synthesis of Fe3O4 Magnetic Nanoparticles on Their Applicability for Magnetic Hyperthermia
| Resumo: | Nanotechnology, specifically magnetic nanoparticles (MNPs), is revolutionizing cancer treatment. Magnetic hyperthermia is a treatment that, using MNPs, can selectively kill cancer cells without causing damage to the surrounding tissues. Background/Objectives: This work aimed to analyze how the synthesis conditions, namely, how the pH of the reaction can influence the magnetic properties of Fe3O4 nanoparticles for magnetic hyperthermia, using the hydrothermal synthesis. Methods: For the hydrothermal synthesis, FeCl3·6H2O and FeCl2·4H2O were mixed with different quantities of NaOH to adjust the pH. After obtaining a black precipitate, the samples were placed in an autoclave at 200 °C for 60 h, followed by a washing and drying phase. The obtained MNPs were analyzed using X-Ray Diffraction (XRD), Transmission Electron Microscopy, a Superconducting Quantum Interference Device, Specific Absorption Rate analysis, and cytotoxicity assays. Results: Different MNPs were analyzed (9.06 < pH < 12.75). The XRD results showed the presence of various iron oxide phases (magnetite, maghemite, and hematite), resulting from the oxidization of the iron phases present in the autoclave. In terms of the average particle size, it was verified that, by increasing the pH value, the size decreases (from 53.53 nm to 9.49 nm). Additionally, MNPs possess a superparamagnetic behaviour with high SAR values (above 69.3 W/g). Conclusions: It was found that the pH of the reaction can influence the size, morphology, magnetization, and thermal efficiency of the MNP. The MNP with the highest composition of Fe3O4 was synthesized with a pH of 12.75, with a cubic morphology and a SAR value of 92.7 ± 3.2 W/g. |
|---|---|
| Autores principais: | Costa, Bárbara |
| Outros Autores: | Pereira, Eurico; Ferreira-Filho, Vital C.; Pires, Ana Salomé; Pereira, Laura C.J.; Soares, Paula I.P.; Botelho, Maria Filomena; Mendes, Fernando; Graça, Manuel P.F.; Teixeira, Sílvia Soreto |
| Assunto: | hydrothermal synthesis magnetic hyperthermia magnetite NaOH SAR Pharmaceutical Science SDG 3 - Good Health and Well-being |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| _version_ | 1868982993117249536 |
|---|---|
| author | Costa, Bárbara |
| author2 | Pereira, Eurico Ferreira-Filho, Vital C. Pires, Ana Salomé Pereira, Laura C.J. Soares, Paula I.P. Botelho, Maria Filomena Mendes, Fernando Graça, Manuel P.F. Teixeira, Sílvia Soreto |
| author2_role | author author author author author author author author author |
| author_facet | Costa, Bárbara Pereira, Eurico Ferreira-Filho, Vital C. Pires, Ana Salomé Pereira, Laura C.J. Soares, Paula I.P. Botelho, Maria Filomena Mendes, Fernando Graça, Manuel P.F. Teixeira, Sílvia Soreto |
| author_role | author |
| contributor_name_str_mv | CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N) DCM - Departamento de Ciência dos Materiais Faculdade de Ciências e Tecnologia (FCT) MDPI - Multidisciplinary Digital Publishing Institute RUN |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Costa, Bárbara\"},{\"Person.name\":\"Pereira, Eurico\"},{\"Person.name\":\"Ferreira-Filho, Vital C.\"},{\"Person.name\":\"Pires, Ana Salomé\"},{\"Person.name\":\"Pereira, Laura C.J.\"},{\"Person.name\":\"Soares, Paula I.P.\"},{\"Person.name\":\"Botelho, Maria Filomena\"},{\"Person.name\":\"Mendes, Fernando\"},{\"Person.name\":\"Graça, Manuel P.F.\"},{\"Person.name\":\"Teixeira, Sílvia Soreto\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N) DCM - Departamento de Ciência dos Materiais Faculdade de Ciências e Tecnologia (FCT) MDPI - Multidisciplinary Digital Publishing Institute RUN |
| datacite.creators.creator.creatorName.fl_str_mv | Costa, Bárbara Pereira, Eurico Ferreira-Filho, Vital C. Pires, Ana Salomé Pereira, Laura C.J. Soares, Paula I.P. Botelho, Maria Filomena Mendes, Fernando Graça, Manuel P.F. Teixeira, Sílvia Soreto |
| datacite.date.Accepted.fl_str_mv | 2025-07-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2025-09-03T22:08:28Z |
| datacite.date.embargoed.fl_str_mv | 2025-09-03T22:08:28Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | hydrothermal synthesis magnetic hyperthermia magnetite NaOH SAR Pharmaceutical Science SDG 3 - Good Health and Well-being |
| datacite.titles.title.fl_str_mv | Influence of the pH Synthesis of Fe3O4 Magnetic Nanoparticles on Their Applicability for Magnetic Hyperthermia An In Vitro Analysis |
| dc.contributor.none.fl_str_mv | CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N) DCM - Departamento de Ciência dos Materiais Faculdade de Ciências e Tecnologia (FCT) MDPI - Multidisciplinary Digital Publishing Institute RUN |
| dc.creator.none.fl_str_mv | Costa, Bárbara Pereira, Eurico Ferreira-Filho, Vital C. Pires, Ana Salomé Pereira, Laura C.J. Soares, Paula I.P. Botelho, Maria Filomena Mendes, Fernando Graça, Manuel P.F. Teixeira, Sílvia Soreto |
| dc.date.Accepted.fl_str_mv | 2025-07-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2025-09-03T22:08:28Z |
| dc.date.embargoed.fl_str_mv | 2025-09-03T22:08:28Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10362/187511 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | hydrothermal synthesis magnetic hyperthermia magnetite NaOH SAR Pharmaceutical Science SDG 3 - Good Health and Well-being |
| dc.title.fl_str_mv | Influence of the pH Synthesis of Fe3O4 Magnetic Nanoparticles on Their Applicability for Magnetic Hyperthermia An In Vitro Analysis |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Nanotechnology, specifically magnetic nanoparticles (MNPs), is revolutionizing cancer treatment. Magnetic hyperthermia is a treatment that, using MNPs, can selectively kill cancer cells without causing damage to the surrounding tissues. Background/Objectives: This work aimed to analyze how the synthesis conditions, namely, how the pH of the reaction can influence the magnetic properties of Fe3O4 nanoparticles for magnetic hyperthermia, using the hydrothermal synthesis. Methods: For the hydrothermal synthesis, FeCl3·6H2O and FeCl2·4H2O were mixed with different quantities of NaOH to adjust the pH. After obtaining a black precipitate, the samples were placed in an autoclave at 200 °C for 60 h, followed by a washing and drying phase. The obtained MNPs were analyzed using X-Ray Diffraction (XRD), Transmission Electron Microscopy, a Superconducting Quantum Interference Device, Specific Absorption Rate analysis, and cytotoxicity assays. Results: Different MNPs were analyzed (9.06 < pH < 12.75). The XRD results showed the presence of various iron oxide phases (magnetite, maghemite, and hematite), resulting from the oxidization of the iron phases present in the autoclave. In terms of the average particle size, it was verified that, by increasing the pH value, the size decreases (from 53.53 nm to 9.49 nm). Additionally, MNPs possess a superparamagnetic behaviour with high SAR values (above 69.3 W/g). Conclusions: It was found that the pH of the reaction can influence the size, morphology, magnetization, and thermal efficiency of the MNP. The MNP with the highest composition of Fe3O4 was synthesized with a pH of 12.75, with a cubic morphology and a SAR value of 92.7 ± 3.2 W/g. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://run.unl.pt/bitstreams/e778b309-90e0-4b3a-9669-6497bd634e75/download |
| funder_facet_str_mv | FCT{{{_:::_}}}Fundação para a Ciência e a Tecnologia |
| funding.funder.alternateName_str_mv | FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia |
| funding.name_str_mv | 6817 - DCRRNI ID |
| id | run_e805948b436e5b4e45f04efb40a4bb57 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10362/187511 |
| inst_facet_str | urn:organizationAcronym:unl{{{_:::_}}}Universidade Nova de Lisboa |
| instacron_str | unl |
| institution | Universidade Nova de Lisboa |
| instname_str | Universidade Nova de Lisboa |
| language | eng |
| network_acronym_str | run |
| network_name_str | Repositório Institucional da UNL |
| oai_identifier_str | oai:run.unl.pt:10362/187511 |
| organization_str_mv | urn:organizationAcronym:unl |
| person_str_mv | Costa, Bárbara Pereira, Eurico Ferreira-Filho, Vital C. Pires, Ana Salomé Pereira, Laura C.J. Soares, Paula I.P. Botelho, Maria Filomena Mendes, Fernando Graça, Manuel P.F. Teixeira, Sílvia Soreto |
| publishDate | 2025 |
| repo_facet_str | urn:repositoryAcronym:run{{{_:::_}}}Repositório Institucional da UNL |
| reponame_str | Repositório Institucional da UNL |
| repository_id_str | urn:repositoryAcronym:run |
| service_str_mv | urn:repositoryAcronym:run |
| spelling | engenNanotechnology, specifically magnetic nanoparticles (MNPs), is revolutionizing cancer treatment. Magnetic hyperthermia is a treatment that, using MNPs, can selectively kill cancer cells without causing damage to the surrounding tissues. Background/Objectives: This work aimed to analyze how the synthesis conditions, namely, how the pH of the reaction can influence the magnetic properties of Fe3O4 nanoparticles for magnetic hyperthermia, using the hydrothermal synthesis. Methods: For the hydrothermal synthesis, FeCl3·6H2O and FeCl2·4H2O were mixed with different quantities of NaOH to adjust the pH. After obtaining a black precipitate, the samples were placed in an autoclave at 200 °C for 60 h, followed by a washing and drying phase. The obtained MNPs were analyzed using X-Ray Diffraction (XRD), Transmission Electron Microscopy, a Superconducting Quantum Interference Device, Specific Absorption Rate analysis, and cytotoxicity assays. Results: Different MNPs were analyzed (9.06 < pH < 12.75). The XRD results showed the presence of various iron oxide phases (magnetite, maghemite, and hematite), resulting from the oxidization of the iron phases present in the autoclave. In terms of the average particle size, it was verified that, by increasing the pH value, the size decreases (from 53.53 nm to 9.49 nm). Additionally, MNPs possess a superparamagnetic behaviour with high SAR values (above 69.3 W/g). Conclusions: It was found that the pH of the reaction can influence the size, morphology, magnetization, and thermal efficiency of the MNP. The MNP with the highest composition of Fe3O4 was synthesized with a pH of 12.75, with a cubic morphology and a SAR value of 92.7 ± 3.2 W/g.application/pdfenInfluence of the pH Synthesis of Fe3O4 Magnetic Nanoparticles on Their Applicability for Magnetic HyperthermiaSubtitleenAn In Vitro AnalysisCosta, BárbaraPereira, EuricoFerreira-Filho, Vital C.Pires, Ana SaloméPereira, Laura C.J.Soares, Paula I.P.Botelho, Maria FilomenaMendes, FernandoGraça, Manuel P.F.Teixeira, Sílvia SoretoCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DCM - Departamento de Ciência dos MateriaisFaculdade de Ciências e Tecnologia (FCT)MDPI - Multidisciplinary Digital Publishing InstituteHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.ptISSNIsPartOf1999-4923URNIsPartOfPURE: 128640965URNIsPartOfPURE UUID: f3a1e520-9b9b-4f6d-b15d-6bfab4eb6303URNIsPartOfScopus: 105011698549URNIsPartOfWOS: 001541063500001URNIsPartOfPubMed: 40733053DOIIsPartOf10.3390/pharmaceutics170708442025-09-03T22:08:28Z2025-072025-07-01T00:00:00ZHandlehttp://hdl.handle.net/10362/187511http://purl.org/coar/access_right/c_abf2open accesshydrothermal synthesismagnetic hyperthermiamagnetiteNaOHSARPharmaceutical ScienceSDG 3 - Good Health and Well-being3202528 bytesFundação para a Ciência e a TecnologiaInstitute of Nanostructures, Nanomodelling and Nanofabrication6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/e778b309-90e0-4b3a-9669-6497bd634e75/download |
| spellingShingle | Influence of the pH Synthesis of Fe3O4 Magnetic Nanoparticles on Their Applicability for Magnetic Hyperthermia Costa, Bárbara hydrothermal synthesis magnetic hyperthermia magnetite NaOH SAR Pharmaceutical Science SDG 3 - Good Health and Well-being |
| status | SINGLETON |
| subject.fl_str_mv | hydrothermal synthesis magnetic hyperthermia magnetite NaOH SAR Pharmaceutical Science SDG 3 - Good Health and Well-being |
| title | Influence of the pH Synthesis of Fe3O4 Magnetic Nanoparticles on Their Applicability for Magnetic Hyperthermia |
| title_full | Influence of the pH Synthesis of Fe3O4 Magnetic Nanoparticles on Their Applicability for Magnetic Hyperthermia |
| title_fullStr | Influence of the pH Synthesis of Fe3O4 Magnetic Nanoparticles on Their Applicability for Magnetic Hyperthermia |
| title_full_unstemmed | Influence of the pH Synthesis of Fe3O4 Magnetic Nanoparticles on Their Applicability for Magnetic Hyperthermia |
| title_short | Influence of the pH Synthesis of Fe3O4 Magnetic Nanoparticles on Their Applicability for Magnetic Hyperthermia |
| title_sort | Influence of the pH Synthesis of Fe3O4 Magnetic Nanoparticles on Their Applicability for Magnetic Hyperthermia |
| topic | hydrothermal synthesis magnetic hyperthermia magnetite NaOH SAR Pharmaceutical Science SDG 3 - Good Health and Well-being |
| topic_facet | hydrothermal synthesis magnetic hyperthermia magnetite NaOH SAR Pharmaceutical Science SDG 3 - Good Health and Well-being |
| url | http://hdl.handle.net/10362/187511 |
| visible | 1 |