Publicação
Serum adipokine profile and fatty acid composition of adipose tissues are affected by conjugated linoleic acid and saturated fat diets in obese Zucker rats
| Resumo: | Conjugated linoleic acid (CLA) has been reported as having body fat lowering properties and the ability to modulate the inflammatory system in several models. In the present study, the effects of CLA added to saturated fat diets, from vegetable and animal origins, on the serum adipokine profile of obese Zucker rats were assessed. In addition, the fatty acid composition of epididymal and retroperitoneal adipose tissues was determined and a principal component analysis (PCA) was used to assess possible relationships between fatty acids and serum metabolites. Atherogenic diets (2% cholesterol) were formulated with palm oil and ovine fat and supplemented or not with 1% of a mixture (1:1) of cis-9, trans-11 and trans-10, cis-12-CLA isomers. CLA-fed animals exhibited lower daily feed intake, final body and liver weights, and hepatic lipids content. Total and LDL-cholesterol levels were increased in CLA-supplemented groups. CLA also promoted higher adiponectin and lower plasminogen activator inhibitor-1 (PAI-1) serum concentrations. In contrast to palm oil diets, ovine fat increased insulin resistance and serum levels of leptin, TNF-α and IL-1β. Epididymal and retroperitoneal adipose tissues had similar deposition of individual fatty acids. The PCA analysis showed that the trans-10, cis-12-CLA isomer was highly associated with adiponectin and PAI-1 levels. Summing up, CLA added to vegetable saturated enriched diets, relative to those from animal origin, seems to improve the serum profile of adipokines and inflammatory markers in obese Zucker rats due to a more favourable fatty acid composition. © 2009 The Authors. |
|---|---|
| Autores principais: | Martins, S.V. |
| Outros Autores: | Lopes, P.A.; Alfaia, C.M.; Rodrigues, P.O.; Alves, S.P.; Pinto, R.M.A.; Castro, M.F.; Bessa, R.J.B.; Prates, J.A.M. |
| Assunto: | Adipokines Conjugated linoleic acid Fatty acids Obese Zucker rats Saturated diets adipocytokine adiponectin C reactive protein conjugated linoleic acid interleukin 1beta interleukin 6 leptin low density lipoprotein cholesterol monounsaturated fatty acid palm oil plasminogen activator inhibitor 1 polyunsaturated fatty acid saturated fatty acid tumor necrosis factor alpha cholesterol edible oil fatty acid lipid trans 10,cis 12 conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid vegetable oil animal experiment animal model animal tissue article atherogenic diet body weight cholesterol blood level controlled study epididymis fat inflammation insulin resistance lipid composition lipid liver level lipid storage liver weight male nonhuman obesity principal component analysis rat retroperitoneal fat adipose tissue animal blood body composition chemistry epididymis fat intake histology intraabdominal fat liver metabolism organ size sheep Zucker rat Animalia Ovis Rattus Adipose Tissue Animals Body Composition Cholesterol Dietary Fats Dietary Fats, Unsaturated Epididymis Fatty Acids Intra-Abdominal Fat Linoleic Acids, Conjugated Lipids Liver Male Obesity Organ Size Plant Oils Plasminogen Activator Inhibitor 1 Rats Rats, Zucker Sheep SDG 3 - Good Health and Well-being |
| Ano: | 2010 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| _version_ | 1868982685967319040 |
|---|---|
| author | Martins, S.V. |
| author2 | Lopes, P.A. Alfaia, C.M. Rodrigues, P.O. Alves, S.P. Pinto, R.M.A. Castro, M.F. Bessa, R.J.B. Prates, J.A.M. |
| author2_role | author author author author author author author author |
| author_facet | Martins, S.V. Lopes, P.A. Alfaia, C.M. Rodrigues, P.O. Alves, S.P. Pinto, R.M.A. Castro, M.F. Bessa, R.J.B. Prates, J.A.M. |
| author_role | author |
| contributor_name_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Cambridge University Press RUN |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Martins, S.V.\"},{\"Person.name\":\"Lopes, P.A.\"},{\"Person.name\":\"Alfaia, C.M.\"},{\"Person.name\":\"Rodrigues, P.O.\"},{\"Person.name\":\"Alves, S.P.\"},{\"Person.name\":\"Pinto, R.M.A.\"},{\"Person.name\":\"Castro, M.F.\"},{\"Person.name\":\"Bessa, R.J.B.\"},{\"Person.name\":\"Prates, J.A.M.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Cambridge University Press RUN |
| datacite.creators.creator.creatorName.fl_str_mv | Martins, S.V. Lopes, P.A. Alfaia, C.M. Rodrigues, P.O. Alves, S.P. Pinto, R.M.A. Castro, M.F. Bessa, R.J.B. Prates, J.A.M. |
| datacite.date.Accepted.fl_str_mv | 2010-03-28T00:00:00Z |
| datacite.date.available.fl_str_mv | 2022-07-23T00:31:24Z |
| datacite.date.embargoed.fl_str_mv | 2022-07-23T00:31:24Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Adipokines Conjugated linoleic acid Fatty acids Obese Zucker rats Saturated diets adipocytokine adiponectin C reactive protein conjugated linoleic acid interleukin 1beta interleukin 6 leptin low density lipoprotein cholesterol monounsaturated fatty acid palm oil plasminogen activator inhibitor 1 polyunsaturated fatty acid saturated fatty acid tumor necrosis factor alpha cholesterol edible oil fatty acid lipid trans 10,cis 12 conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid vegetable oil animal experiment animal model animal tissue article atherogenic diet body weight cholesterol blood level controlled study epididymis fat inflammation insulin resistance lipid composition lipid liver level lipid storage liver weight male nonhuman obesity principal component analysis rat retroperitoneal fat adipose tissue animal blood body composition chemistry epididymis fat intake histology intraabdominal fat liver metabolism organ size sheep Zucker rat Animalia Ovis Rattus Adipose Tissue Animals Body Composition Cholesterol Dietary Fats Dietary Fats, Unsaturated Epididymis Fatty Acids Intra-Abdominal Fat Linoleic Acids, Conjugated Lipids Liver Male Obesity Organ Size Plant Oils Plasminogen Activator Inhibitor 1 Rats Rats, Zucker Sheep SDG 3 - Good Health and Well-being |
| datacite.titles.title.fl_str_mv | Serum adipokine profile and fatty acid composition of adipose tissues are affected by conjugated linoleic acid and saturated fat diets in obese Zucker rats |
| dc.contributor.none.fl_str_mv | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Cambridge University Press RUN |
| dc.creator.none.fl_str_mv | Martins, S.V. Lopes, P.A. Alfaia, C.M. Rodrigues, P.O. Alves, S.P. Pinto, R.M.A. Castro, M.F. Bessa, R.J.B. Prates, J.A.M. |
| dc.date.Accepted.fl_str_mv | 2010-03-28T00:00:00Z |
| dc.date.available.fl_str_mv | 2022-07-23T00:31:24Z |
| dc.date.embargoed.fl_str_mv | 2022-07-23T00:31:24Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10362/142151 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Adipokines Conjugated linoleic acid Fatty acids Obese Zucker rats Saturated diets adipocytokine adiponectin C reactive protein conjugated linoleic acid interleukin 1beta interleukin 6 leptin low density lipoprotein cholesterol monounsaturated fatty acid palm oil plasminogen activator inhibitor 1 polyunsaturated fatty acid saturated fatty acid tumor necrosis factor alpha cholesterol edible oil fatty acid lipid trans 10,cis 12 conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid vegetable oil animal experiment animal model animal tissue article atherogenic diet body weight cholesterol blood level controlled study epididymis fat inflammation insulin resistance lipid composition lipid liver level lipid storage liver weight male nonhuman obesity principal component analysis rat retroperitoneal fat adipose tissue animal blood body composition chemistry epididymis fat intake histology intraabdominal fat liver metabolism organ size sheep Zucker rat Animalia Ovis Rattus Adipose Tissue Animals Body Composition Cholesterol Dietary Fats Dietary Fats, Unsaturated Epididymis Fatty Acids Intra-Abdominal Fat Linoleic Acids, Conjugated Lipids Liver Male Obesity Organ Size Plant Oils Plasminogen Activator Inhibitor 1 Rats Rats, Zucker Sheep SDG 3 - Good Health and Well-being |
| dc.title.fl_str_mv | Serum adipokine profile and fatty acid composition of adipose tissues are affected by conjugated linoleic acid and saturated fat diets in obese Zucker rats |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Conjugated linoleic acid (CLA) has been reported as having body fat lowering properties and the ability to modulate the inflammatory system in several models. In the present study, the effects of CLA added to saturated fat diets, from vegetable and animal origins, on the serum adipokine profile of obese Zucker rats were assessed. In addition, the fatty acid composition of epididymal and retroperitoneal adipose tissues was determined and a principal component analysis (PCA) was used to assess possible relationships between fatty acids and serum metabolites. Atherogenic diets (2% cholesterol) were formulated with palm oil and ovine fat and supplemented or not with 1% of a mixture (1:1) of cis-9, trans-11 and trans-10, cis-12-CLA isomers. CLA-fed animals exhibited lower daily feed intake, final body and liver weights, and hepatic lipids content. Total and LDL-cholesterol levels were increased in CLA-supplemented groups. CLA also promoted higher adiponectin and lower plasminogen activator inhibitor-1 (PAI-1) serum concentrations. In contrast to palm oil diets, ovine fat increased insulin resistance and serum levels of leptin, TNF-α and IL-1β. Epididymal and retroperitoneal adipose tissues had similar deposition of individual fatty acids. The PCA analysis showed that the trans-10, cis-12-CLA isomer was highly associated with adiponectin and PAI-1 levels. Summing up, CLA added to vegetable saturated enriched diets, relative to those from animal origin, seems to improve the serum profile of adipokines and inflammatory markers in obese Zucker rats due to a more favourable fatty acid composition. © 2009 The Authors. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://run.unl.pt/bitstreams/72f1334f-956a-474b-957b-5dcbec9141d9/download |
| id | run_fe8d9efe3f6c006b2c4b3a7ce39f4e26 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10362/142151 |
| inst_facet_str | urn:organizationAcronym:unl{{{_:::_}}}Universidade Nova de Lisboa |
| instacron_str | unl |
| institution | Universidade Nova de Lisboa |
| instname_str | Universidade Nova de Lisboa |
| language | eng |
| network_acronym_str | run |
| network_name_str | Repositório Institucional da UNL |
| oai_identifier_str | oai:run.unl.pt:10362/142151 |
| organization_str_mv | urn:organizationAcronym:unl |
| person_str_mv | Martins, S.V. Lopes, P.A. Alfaia, C.M. Rodrigues, P.O. Alves, S.P. Pinto, R.M.A. Castro, M.F. Bessa, R.J.B. Prates, J.A.M. |
| publishDate | 2010 |
| repo_facet_str | urn:repositoryAcronym:run{{{_:::_}}}Repositório Institucional da UNL |
| reponame_str | Repositório Institucional da UNL |
| repository_id_str | urn:repositoryAcronym:run |
| service_str_mv | urn:repositoryAcronym:run |
| spelling | engenConjugated linoleic acid (CLA) has been reported as having body fat lowering properties and the ability to modulate the inflammatory system in several models. In the present study, the effects of CLA added to saturated fat diets, from vegetable and animal origins, on the serum adipokine profile of obese Zucker rats were assessed. In addition, the fatty acid composition of epididymal and retroperitoneal adipose tissues was determined and a principal component analysis (PCA) was used to assess possible relationships between fatty acids and serum metabolites. Atherogenic diets (2% cholesterol) were formulated with palm oil and ovine fat and supplemented or not with 1% of a mixture (1:1) of cis-9, trans-11 and trans-10, cis-12-CLA isomers. CLA-fed animals exhibited lower daily feed intake, final body and liver weights, and hepatic lipids content. Total and LDL-cholesterol levels were increased in CLA-supplemented groups. CLA also promoted higher adiponectin and lower plasminogen activator inhibitor-1 (PAI-1) serum concentrations. In contrast to palm oil diets, ovine fat increased insulin resistance and serum levels of leptin, TNF-α and IL-1β. Epididymal and retroperitoneal adipose tissues had similar deposition of individual fatty acids. The PCA analysis showed that the trans-10, cis-12-CLA isomer was highly associated with adiponectin and PAI-1 levels. Summing up, CLA added to vegetable saturated enriched diets, relative to those from animal origin, seems to improve the serum profile of adipokines and inflammatory markers in obese Zucker rats due to a more favourable fatty acid composition. © 2009 The Authors.application/pdfenSerum adipokine profile and fatty acid composition of adipose tissues are affected by conjugated linoleic acid and saturated fat diets in obese Zucker ratsMartins, S.V.Lopes, P.A.Alfaia, C.M.Rodrigues, P.O.Alves, S.P.Pinto, R.M.A.Castro, M.F.Bessa, R.J.B.Prates, J.A.M.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Cambridge University PressHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.ptISSNIsPartOf0007-1145URNIsPartOfPURE: 3167005URNIsPartOfPURE UUID: a6a0109f-455d-430c-b430-996005defba7URNIsPartOfRIS: urn:ECC21F5DA9B45A2FA9FCCAF78C6BD752URNIsPartOfScopus: 77950355294URNIsPartOfPubMed: 19878618URNIsPartOfWOS: 000276230900011DOIIsPartOf10.1017/S000711450999256X2022-07-23T00:31:24Z2010-03-282010-03-28T00:00:00ZHandlehttp://hdl.handle.net/10362/142151http://purl.org/coar/access_right/c_abf2open accessAdipokinesConjugated linoleic acidFatty acidsObese Zucker ratsSaturated dietsadipocytokineadiponectinC reactive proteinconjugated linoleic acidinterleukin 1betainterleukin 6leptinlow density lipoprotein cholesterolmonounsaturated fatty acidpalm oilplasminogen activator inhibitor 1polyunsaturated fatty acidsaturated fatty acidtumor necrosis factor alphacholesteroledible oilfatty acidlipidtrans 10,cis 12 conjugated linoleic acidtrans-10,cis-12-conjugated linoleic acidvegetable oilanimal experimentanimal modelanimal tissuearticleatherogenic dietbody weightcholesterol blood levelcontrolled studyepididymis fatinflammationinsulin resistancelipid compositionlipid liver levellipid storageliver weightmalenonhumanobesityprincipal component analysisratretroperitoneal fatadipose tissueanimalbloodbody compositionchemistryepididymisfat intakehistologyintraabdominal fatlivermetabolismorgan sizesheepZucker ratAnimaliaOvisRattusAdipose TissueAnimalsBody CompositionCholesterolDietary FatsDietary Fats, UnsaturatedEpididymisFatty AcidsIntra-Abdominal FatLinoleic Acids, ConjugatedLipidsLiverMaleObesityOrgan SizePlant OilsPlasminogen Activator Inhibitor 1RatsRats, ZuckerSheepSDG 3 - Good Health and Well-being176196 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/72f1334f-956a-474b-957b-5dcbec9141d9/download |
| spellingShingle | Serum adipokine profile and fatty acid composition of adipose tissues are affected by conjugated linoleic acid and saturated fat diets in obese Zucker rats Martins, S.V. Adipokines Conjugated linoleic acid Fatty acids Obese Zucker rats Saturated diets adipocytokine adiponectin C reactive protein conjugated linoleic acid interleukin 1beta interleukin 6 leptin low density lipoprotein cholesterol monounsaturated fatty acid palm oil plasminogen activator inhibitor 1 polyunsaturated fatty acid saturated fatty acid tumor necrosis factor alpha cholesterol edible oil fatty acid lipid trans 10,cis 12 conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid vegetable oil animal experiment animal model animal tissue article atherogenic diet body weight cholesterol blood level controlled study epididymis fat inflammation insulin resistance lipid composition lipid liver level lipid storage liver weight male nonhuman obesity principal component analysis rat retroperitoneal fat adipose tissue animal blood body composition chemistry epididymis fat intake histology intraabdominal fat liver metabolism organ size sheep Zucker rat Animalia Ovis Rattus Adipose Tissue Animals Body Composition Cholesterol Dietary Fats Dietary Fats, Unsaturated Epididymis Fatty Acids Intra-Abdominal Fat Linoleic Acids, Conjugated Lipids Liver Male Obesity Organ Size Plant Oils Plasminogen Activator Inhibitor 1 Rats Rats, Zucker Sheep SDG 3 - Good Health and Well-being |
| status | SINGLETON |
| subject.fl_str_mv | Adipokines Conjugated linoleic acid Fatty acids Obese Zucker rats Saturated diets adipocytokine adiponectin C reactive protein conjugated linoleic acid interleukin 1beta interleukin 6 leptin low density lipoprotein cholesterol monounsaturated fatty acid palm oil plasminogen activator inhibitor 1 polyunsaturated fatty acid saturated fatty acid tumor necrosis factor alpha cholesterol edible oil fatty acid lipid trans 10,cis 12 conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid vegetable oil animal experiment animal model animal tissue article atherogenic diet body weight cholesterol blood level controlled study epididymis fat inflammation insulin resistance lipid composition lipid liver level lipid storage liver weight male nonhuman obesity principal component analysis rat retroperitoneal fat adipose tissue animal blood body composition chemistry epididymis fat intake histology intraabdominal fat liver metabolism organ size sheep Zucker rat Animalia Ovis Rattus Adipose Tissue Animals Body Composition Cholesterol Dietary Fats Dietary Fats, Unsaturated Epididymis Fatty Acids Intra-Abdominal Fat Linoleic Acids, Conjugated Lipids Liver Male Obesity Organ Size Plant Oils Plasminogen Activator Inhibitor 1 Rats Rats, Zucker Sheep SDG 3 - Good Health and Well-being |
| title | Serum adipokine profile and fatty acid composition of adipose tissues are affected by conjugated linoleic acid and saturated fat diets in obese Zucker rats |
| title_full | Serum adipokine profile and fatty acid composition of adipose tissues are affected by conjugated linoleic acid and saturated fat diets in obese Zucker rats |
| title_fullStr | Serum adipokine profile and fatty acid composition of adipose tissues are affected by conjugated linoleic acid and saturated fat diets in obese Zucker rats |
| title_full_unstemmed | Serum adipokine profile and fatty acid composition of adipose tissues are affected by conjugated linoleic acid and saturated fat diets in obese Zucker rats |
| title_short | Serum adipokine profile and fatty acid composition of adipose tissues are affected by conjugated linoleic acid and saturated fat diets in obese Zucker rats |
| title_sort | Serum adipokine profile and fatty acid composition of adipose tissues are affected by conjugated linoleic acid and saturated fat diets in obese Zucker rats |
| topic | Adipokines Conjugated linoleic acid Fatty acids Obese Zucker rats Saturated diets adipocytokine adiponectin C reactive protein conjugated linoleic acid interleukin 1beta interleukin 6 leptin low density lipoprotein cholesterol monounsaturated fatty acid palm oil plasminogen activator inhibitor 1 polyunsaturated fatty acid saturated fatty acid tumor necrosis factor alpha cholesterol edible oil fatty acid lipid trans 10,cis 12 conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid vegetable oil animal experiment animal model animal tissue article atherogenic diet body weight cholesterol blood level controlled study epididymis fat inflammation insulin resistance lipid composition lipid liver level lipid storage liver weight male nonhuman obesity principal component analysis rat retroperitoneal fat adipose tissue animal blood body composition chemistry epididymis fat intake histology intraabdominal fat liver metabolism organ size sheep Zucker rat Animalia Ovis Rattus Adipose Tissue Animals Body Composition Cholesterol Dietary Fats Dietary Fats, Unsaturated Epididymis Fatty Acids Intra-Abdominal Fat Linoleic Acids, Conjugated Lipids Liver Male Obesity Organ Size Plant Oils Plasminogen Activator Inhibitor 1 Rats Rats, Zucker Sheep SDG 3 - Good Health and Well-being |
| topic_facet | Adipokines Conjugated linoleic acid Fatty acids Obese Zucker rats Saturated diets adipocytokine adiponectin C reactive protein conjugated linoleic acid interleukin 1beta interleukin 6 leptin low density lipoprotein cholesterol monounsaturated fatty acid palm oil plasminogen activator inhibitor 1 polyunsaturated fatty acid saturated fatty acid tumor necrosis factor alpha cholesterol edible oil fatty acid lipid trans 10,cis 12 conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid vegetable oil animal experiment animal model animal tissue article atherogenic diet body weight cholesterol blood level controlled study epididymis fat inflammation insulin resistance lipid composition lipid liver level lipid storage liver weight male nonhuman obesity principal component analysis rat retroperitoneal fat adipose tissue animal blood body composition chemistry epididymis fat intake histology intraabdominal fat liver metabolism organ size sheep Zucker rat Animalia Ovis Rattus Adipose Tissue Animals Body Composition Cholesterol Dietary Fats Dietary Fats, Unsaturated Epididymis Fatty Acids Intra-Abdominal Fat Linoleic Acids, Conjugated Lipids Liver Male Obesity Organ Size Plant Oils Plasminogen Activator Inhibitor 1 Rats Rats, Zucker Sheep SDG 3 - Good Health and Well-being |
| url | http://hdl.handle.net/10362/142151 |
| visible | 1 |