Publicação
Allatostatin-type A, kisspeptin and galanin GPCRs and putative ligands as candidate regulatory factors of mantle function
| Resumo: | Allatostatin-type A (AST-A), kisspeptin (KISS) and galanin (GAL) G-protein coupled receptor (GPCR) systems share a common ancestral origin in arthropods and the vertebrates where they regulate metabolism and reproduction. The molluscs are the second most diverse phylum in the animal kingdom, they occupy an important phylogenetic position, and their genome is more similar to deuterostomes than the arthropods and nematodes and thus they are good models for studies of gene family evolution and function. This mini-review intends to extend the current knowledge about AST-A, KISS and GAL GPCR system evolution and their putative function in the mollusc mantle. Comparative evolutionary analysis of the target GPCR systems was established by identifying homologues in genomes and tissue transcriptome datasets available for molluscs and comparing them to those of other metazoan systems. Studies in arthropods have revealed the existence of the AST-A system but the loss of homologues of the KISS and GAL systems. Homologues of the insect AST-AR and vertebrate KISSR genes were found in molluscs but putative GALR genes were absent. Receptor gene number suggested that members of this family have suffered lineage specific evolution during the molluscan radiation. In molluscs, orthologues of the insect AST-A peptides were not identified but buccalin peptides that are structurally related were identified and are putative receptor agonists. The identification of AST-AR and KISSR genes in molluscs strengthens the hypotheses that in metazoans members of the AST-AR subfamily share evolutionary proximity with KISSRs. The variable number of receptors and large repertoire of buccalin peptides may be indicative of the functional diversity of the AST-AR/IGSSR systems in molluscs. The identification of AST-A and KISS receptors and ligands in the mantle transcriptome indicates that in molluscs they may have acquired a novel function and may play a role in shell development or sensory detection in the mantle. |
|---|---|
| Autores principais: | Cardoso, João CR |
| Outros Autores: | Félix, Rute C.; Bjarnmark, Nadege; Power, Deborah |
| Assunto: | AST-A and KISS GPCRs Evolution Genes and transcripts Molluscs Peptides |
| Ano: | 2016 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Algarve |
| Idioma: | inglês |
| Origem: | Sapientia - Universidade do Algarve |
| _version_ | 1867051060328136704 |
|---|---|
| author | Cardoso, João CR |
| author2 | Félix, Rute C. Bjarnmark, Nadege Power, Deborah |
| author2_role | author author author |
| author_facet | Cardoso, João CR Félix, Rute C. Bjarnmark, Nadege Power, Deborah |
| author_role | author |
| contributor_name_str_mv | Sapientia |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Cardoso, João CR\",\"Person.identifier.orcid\":\"0000-0001-7890-0170\"},{\"Person.name\":\"Félix, Rute C.\"},{\"Person.name\":\"Bjarnmark, Nadege\"},{\"Person.name\":\"Power, Deborah\",\"Person.identifier.orcid\":\"0000-0003-1366-0246\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Sapientia |
| datacite.creators.creator.creatorName.fl_str_mv | Cardoso, João CR Félix, Rute C. Bjarnmark, Nadege Power, Deborah |
| datacite.date.Accepted.fl_str_mv | 2016-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2017-04-07T15:56:33Z |
| datacite.date.embargoed.fl_str_mv | 2017-04-07T15:56:33Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | AST-A and KISS GPCRs Evolution Genes and transcripts Molluscs Peptides |
| datacite.titles.title.fl_str_mv | Allatostatin-type A, kisspeptin and galanin GPCRs and putative ligands as candidate regulatory factors of mantle function |
| dc.contributor.none.fl_str_mv | Sapientia |
| dc.creator.none.fl_str_mv | Cardoso, João CR Félix, Rute C. Bjarnmark, Nadege Power, Deborah |
| dc.date.Accepted.fl_str_mv | 2016-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2017-04-07T15:56:33Z |
| dc.date.embargoed.fl_str_mv | 2017-04-07T15:56:33Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.1/9453 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | AST-A and KISS GPCRs Evolution Genes and transcripts Molluscs Peptides |
| dc.title.fl_str_mv | Allatostatin-type A, kisspeptin and galanin GPCRs and putative ligands as candidate regulatory factors of mantle function |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Allatostatin-type A (AST-A), kisspeptin (KISS) and galanin (GAL) G-protein coupled receptor (GPCR) systems share a common ancestral origin in arthropods and the vertebrates where they regulate metabolism and reproduction. The molluscs are the second most diverse phylum in the animal kingdom, they occupy an important phylogenetic position, and their genome is more similar to deuterostomes than the arthropods and nematodes and thus they are good models for studies of gene family evolution and function. This mini-review intends to extend the current knowledge about AST-A, KISS and GAL GPCR system evolution and their putative function in the mollusc mantle. Comparative evolutionary analysis of the target GPCR systems was established by identifying homologues in genomes and tissue transcriptome datasets available for molluscs and comparing them to those of other metazoan systems. Studies in arthropods have revealed the existence of the AST-A system but the loss of homologues of the KISS and GAL systems. Homologues of the insect AST-AR and vertebrate KISSR genes were found in molluscs but putative GALR genes were absent. Receptor gene number suggested that members of this family have suffered lineage specific evolution during the molluscan radiation. In molluscs, orthologues of the insect AST-A peptides were not identified but buccalin peptides that are structurally related were identified and are putative receptor agonists. The identification of AST-AR and KISSR genes in molluscs strengthens the hypotheses that in metazoans members of the AST-AR subfamily share evolutionary proximity with KISSRs. The variable number of receptors and large repertoire of buccalin peptides may be indicative of the functional diversity of the AST-AR/IGSSR systems in molluscs. The identification of AST-A and KISS receptors and ligands in the mantle transcriptome indicates that in molluscs they may have acquired a novel function and may play a role in shell development or sensory detection in the mantle. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://sapientia.ualg.pt/bitstreams/0bf9a36b-c627-4f38-b059-aace015c4693/download |
| funding.funder.alternateName_str_mv | EC |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100008530 |
| funding.funder.name_str_mv | European Commission |
| funding.name_str_mv | FP7 |
| id | sapientia_a9c1908f9f0e862dcd3ceacfe6489bd0 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.1/9453 |
| instacron_str | ualg |
| institution | Universidade do Algarve |
| instname_str | Universidade do Algarve |
| language | eng |
| network_acronym_str | sapientia |
| network_name_str | Sapientia - Universidade do Algarve |
| oai_identifier_str | oai:sapientia.ualg.pt:10400.1/9453 |
| organization_str_mv | urn:organizationAcronym:ualg |
| person_str_mv | Cardoso, João CR Cardoso, João CR https://www.ciencia-id.pt/8B16-F203-2AFC 8B16-F203-2AFC http://orcid.org/0000-0001-7890-0170 0000-0001-7890-0170 Félix, Rute C. Bjarnmark, Nadege Power, Deborah Power, Deborah https://www.ciencia-id.pt/891A-8A44-3CAE 891A-8A44-3CAE http://orcid.org/0000-0003-1366-0246 0000-0003-1366-0246 |
| publishDate | 2016 |
| reponame_str | Sapientia - Universidade do Algarve |
| repository_id_str | urn:repositoryAcronym:sapientia |
| service_str_mv | urn:repositoryAcronym:sapientia |
| spelling | engAllatostatin-type A (AST-A), kisspeptin (KISS) and galanin (GAL) G-protein coupled receptor (GPCR) systems share a common ancestral origin in arthropods and the vertebrates where they regulate metabolism and reproduction. The molluscs are the second most diverse phylum in the animal kingdom, they occupy an important phylogenetic position, and their genome is more similar to deuterostomes than the arthropods and nematodes and thus they are good models for studies of gene family evolution and function. This mini-review intends to extend the current knowledge about AST-A, KISS and GAL GPCR system evolution and their putative function in the mollusc mantle. Comparative evolutionary analysis of the target GPCR systems was established by identifying homologues in genomes and tissue transcriptome datasets available for molluscs and comparing them to those of other metazoan systems. Studies in arthropods have revealed the existence of the AST-A system but the loss of homologues of the KISS and GAL systems. Homologues of the insect AST-AR and vertebrate KISSR genes were found in molluscs but putative GALR genes were absent. Receptor gene number suggested that members of this family have suffered lineage specific evolution during the molluscan radiation. In molluscs, orthologues of the insect AST-A peptides were not identified but buccalin peptides that are structurally related were identified and are putative receptor agonists. The identification of AST-AR and KISSR genes in molluscs strengthens the hypotheses that in metazoans members of the AST-AR subfamily share evolutionary proximity with KISSRs. The variable number of receptors and large repertoire of buccalin peptides may be indicative of the functional diversity of the AST-AR/IGSSR systems in molluscs. The identification of AST-A and KISS receptors and ligands in the mantle transcriptome indicates that in molluscs they may have acquired a novel function and may play a role in shell development or sensory detection in the mantle.application/pdfAllatostatin-type A, kisspeptin and galanin GPCRs and putative ligands as candidate regulatory factors of mantle functionPersonalCardoso, João CRDSpacehttp://dspace.org/items/1b670c84-15e3-4776-8871-50f9eb0eed0dDSpacehttp://dspace.org/items/1b670c84-15e3-4776-8871-50f9eb0eed0dCardosoJoãoCiência IDhttps://www.ciencia-id.pt8B16-F203-2AFCORCIDhttp://orcid.org0000-0001-7890-0170Researcher IDhttps://www.researcherid.comM-4151-2013Scopus Author IDhttps://www.scopus.com7201822956Félix, Rute C.Bjarnmark, NadegePersonalPower, DeborahDSpacehttp://dspace.org/items/c68f5ffb-63f6-4c70-8957-29e464fb59c0DSpacehttp://dspace.org/items/c68f5ffb-63f6-4c70-8957-29e464fb59c0PowerDeborah MaryCiência IDhttps://www.ciencia-id.pt891A-8A44-3CAEORCIDhttp://orcid.org0000-0003-1366-0246Scopus Author IDhttps://www.scopus.com7101806760HostingInstitutionOrganizationalSapientiae-mailmailto:repositorio@ualg.ptrepositorio@ualg.ptISSNIsPartOf1874-7787URNIsPartOfAUT: DPO00386;DOIIsPartOfhttp://dx.doi.org/10.1016/j.margen.2015.12.0032017-04-07T15:56:33Z20162016-01-01T00:00:00ZHandlehttp://hdl.handle.net/10400.1/9453http://purl.org/coar/access_right/c_abf2open accessAST-A and KISS GPCRsEvolutionGenes and transcriptsMolluscsPeptides1406353 bytesEuropean CommissionCACHE: CAlcium in a CHanging EnvironmentFP7Crossref Funder IDhttp://doi.org/10.13039/501100008530literaturehttp://purl.org/coar/resource_type/c_6501journal article2016http://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://sapientia.ualg.pt/bitstreams/0bf9a36b-c627-4f38-b059-aace015c4693/downloadMarine Genomics272535 |
| spellingShingle | Allatostatin-type A, kisspeptin and galanin GPCRs and putative ligands as candidate regulatory factors of mantle function Cardoso, João CR AST-A and KISS GPCRs Evolution Genes and transcripts Molluscs Peptides |
| status | SINGLETON |
| subject.fl_str_mv | AST-A and KISS GPCRs Evolution Genes and transcripts Molluscs Peptides |
| title | Allatostatin-type A, kisspeptin and galanin GPCRs and putative ligands as candidate regulatory factors of mantle function |
| title_full | Allatostatin-type A, kisspeptin and galanin GPCRs and putative ligands as candidate regulatory factors of mantle function |
| title_fullStr | Allatostatin-type A, kisspeptin and galanin GPCRs and putative ligands as candidate regulatory factors of mantle function |
| title_full_unstemmed | Allatostatin-type A, kisspeptin and galanin GPCRs and putative ligands as candidate regulatory factors of mantle function |
| title_short | Allatostatin-type A, kisspeptin and galanin GPCRs and putative ligands as candidate regulatory factors of mantle function |
| title_sort | Allatostatin-type A, kisspeptin and galanin GPCRs and putative ligands as candidate regulatory factors of mantle function |
| topic | AST-A and KISS GPCRs Evolution Genes and transcripts Molluscs Peptides |
| topic_facet | AST-A and KISS GPCRs Evolution Genes and transcripts Molluscs Peptides |
| url | http://hdl.handle.net/10400.1/9453 |
| visible | 1 |