Publicação
Celiac disease and upper tract Crohns disease: A rare association
| Resumo: | The authors present the case of a 47 years old female, with no past or familial history, hospitalized due to vomiting and significant weight loss over the last 9 months, without abdominal pain, blood loss, constipation or diarrhoea. Blood tests results revealed iron deficiency anaemia, seropositivity for ASCA, anti-transglutaminase antibody and HLA-DQ2. Upper GI endoscopy showed several ulcers in duodenal mucosa and an ulcerated stricture in D3; biopsies were taken and histopathology revealed transmural inflammatory chronic infiltrate, crypt loss and some areas of villous atrophy and intraepithelial lymphocytosis. The small bowel follow through confirmed 2 main strictures in duodenum and proximal jejunum. She was started on prednisolone, azathioprine and a gluten-free diet with an initial good response although relapse was detected one month later. In this last admission, parenteral nutrition was necessary due to her deteriorated nutritional state and she also started infliximab, with subsequent significant clinical and endoscopic improvement |
|---|---|
| Autores principais: | Alberto,Sara Folgado |
| Outros Autores: | Martins,Alexandra; Deus,João Ramos de |
| Assunto: | Crohns disease celiac disease association small bowel stricture infliximab |
| Ano: | 2012 |
| País: | Portugal |
| Tipo de documento: | relatório |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Fundação para a Ciência e Tecnologia |
| Idioma: | inglês |
| Origem: | SciELO Portugal |
| _version_ | 1868441738002038784 |
|---|---|
| author | Alberto,Sara Folgado |
| author2 | Martins,Alexandra Deus,João Ramos de |
| author2_role | author author |
| author_facet | Alberto,Sara Folgado Martins,Alexandra Deus,João Ramos de |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Alberto,Sara Folgado\"},{\"Person.name\":\"Martins,Alexandra\"},{\"Person.name\":\"Deus,João Ramos de\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Alberto,Sara Folgado Martins,Alexandra Deus,João Ramos de |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Crohns disease celiac disease association small bowel stricture infliximab |
| datacite.titles.title.fl_str_mv | Celiac disease and upper tract Crohns disease: A rare association |
| dc.creator.none.fl_str_mv | Alberto,Sara Folgado Martins,Alexandra Deus,João Ramos de |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782012000100006 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Sociedade Portuguesa de Gastrenterologia |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | Jornal Português de Gastrenterologia v.19 n.1 2012 |
| dc.subject.none.fl_str_mv | Crohns disease celiac disease association small bowel stricture infliximab |
| dc.title.fl_str_mv | Celiac disease and upper tract Crohns disease: A rare association |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_93fc |
| description | The authors present the case of a 47 years old female, with no past or familial history, hospitalized due to vomiting and significant weight loss over the last 9 months, without abdominal pain, blood loss, constipation or diarrhoea. Blood tests results revealed iron deficiency anaemia, seropositivity for ASCA, anti-transglutaminase antibody and HLA-DQ2. Upper GI endoscopy showed several ulcers in duodenal mucosa and an ulcerated stricture in D3; biopsies were taken and histopathology revealed transmural inflammatory chronic infiltrate, crypt loss and some areas of villous atrophy and intraepithelial lymphocytosis. The small bowel follow through confirmed 2 main strictures in duodenum and proximal jejunum. She was started on prednisolone, azathioprine and a gluten-free diet with an initial good response although relapse was detected one month later. In this last admission, parenteral nutrition was necessary due to her deteriorated nutritional state and she also started infliximab, with subsequent significant clinical and endoscopic improvement |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | report |
| id | scielopt_150fa33e78cc5fc0f27eb7dc8673ee4e |
| identifier.url.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782012000100006 |
| instacron_str | SciELO |
| institution | Fundação para a Ciência e Tecnologia |
| instname_str | Fundação para a Ciência e Tecnologia |
| language | eng |
| network_acronym_str | scielopt |
| network_name_str | SciELO Portugal |
| oai_identifier_str | oai:scielo:S0872-81782012000100006 |
| organization_str_mv | urn:organizationAcronym:scielo |
| person_str_mv | Alberto,Sara Folgado Martins,Alexandra Deus,João Ramos de |
| publishDate | 2012 |
| publisher.none.fl_str_mv | Sociedade Portuguesa de Gastrenterologia |
| reponame_str | SciELO Portugal |
| repository_id_str | urn:repositoryAcronym:scielopt |
| service_str_mv | urn:repositoryAcronym:scielopt |
| spelling | Celiac disease and upper tract Crohns disease: A rare associationAlberto,Sara FolgadoMartins,AlexandraDeus,João Ramos deCrohns diseaseceliac diseaseassociationsmall bowel strictureinfliximabopen accesshttp://purl.org/coar/access_right/c_abf2http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782012000100006URLhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782012000100006URLHasVersion2012-01-01The authors present the case of a 47 years old female, with no past or familial history, hospitalized due to vomiting and significant weight loss over the last 9 months, without abdominal pain, blood loss, constipation or diarrhoea. Blood tests results revealed iron deficiency anaemia, seropositivity for ASCA, anti-transglutaminase antibody and HLA-DQ2. Upper GI endoscopy showed several ulcers in duodenal mucosa and an ulcerated stricture in D3; biopsies were taken and histopathology revealed transmural inflammatory chronic infiltrate, crypt loss and some areas of villous atrophy and intraepithelial lymphocytosis. The small bowel follow through confirmed 2 main strictures in duodenum and proximal jejunum. She was started on prednisolone, azathioprine and a gluten-free diet with an initial good response although relapse was detected one month later. In this last admission, parenteral nutrition was necessary due to her deteriorated nutritional state and she also started infliximab, with subsequent significant clinical and endoscopic improvementSociedade Portuguesa de GastrenterologiaJornal Português de Gastrenterologia v.19 n.1 2012text/htmlengreporthttp://purl.org/coar/resource_type/c_93fcother research product |
| spellingShingle | Celiac disease and upper tract Crohns disease: A rare association Alberto,Sara Folgado Crohns disease celiac disease association small bowel stricture infliximab |
| status | SINGLETON |
| subject.fl_str_mv | Crohns disease celiac disease association small bowel stricture infliximab |
| title | Celiac disease and upper tract Crohns disease: A rare association |
| title_full | Celiac disease and upper tract Crohns disease: A rare association |
| title_fullStr | Celiac disease and upper tract Crohns disease: A rare association |
| title_full_unstemmed | Celiac disease and upper tract Crohns disease: A rare association |
| title_short | Celiac disease and upper tract Crohns disease: A rare association |
| title_sort | Celiac disease and upper tract Crohns disease: A rare association |
| topic | Crohns disease celiac disease association small bowel stricture infliximab |
| topic_facet | Crohns disease celiac disease association small bowel stricture infliximab |
| url | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782012000100006 |
| visible | 1 |