Publicação
Clinicopathological profile and prognosis of idiopathic membranous nephropathy in adults: a developing country perspective
| Resumo: | Background: There is no study available from Pakistan on the longitudinal course of membranous nephropathy (MN). We aimed to analyse the clinicopathological profile, course, response to treatment and outcome of the disease in our setup. Methods: All consecutive adult patients (≥18 years) with MN on renal biopsy and on regular follow-up were included. Relevant data items were retrieved from case files and biopsy reports. The outcome variables included doubling of baseline serum creatinine or the development of end-stage renal disease (ESRD). Results: Of a total of 102 patients, 82 (80.4%) were males; mean age was 28.9±11.4 years. Peripheral oedema was present in 86 (84.3%), nephrotic-range proteinuria in 80 (78.4%), microscopic haematuria in 25 (24.5%), hypertension in 42 (41.2%), and renal dysfunction in 13 (12.7%) patients at the time of presentation. The mean follow-up period was 3±2 years. Overall, 22 (21.5%) subjects went into remission and a similar number experienced doubling of serum creatinine. Both conservative and immunosuppressive treatment groups had similar duration of follow-up. The proportion of patients with remission and doubling of serum creatinine was similar between the two groups (p=0.70 and p=0.91 respectively), while the proportion of patients progressing to ESRD was significantly higher in the group treated conservatively (p=0.03). Baseline proteinuria and serum creatinine were predictive of remission (p=0.04 and p=0.05 respectively). Conclusions: In conclusion, untreated MN has a higher risk of progression to ESRD. Baseline proteinuria and serum creatinine predict response to treatment. Randomised controlled trials are needed to confirm the effects of immunosuppressive treatment |
|---|---|
| Autores principais: | Hyder Rizvi,Syed Abbas |
| Outros Autores: | Naqvi,Rubina; Ahmed,Ejaz; Akhter,Fazal; Abbas,Khawar; Mubarak,Muhammed |
| Assunto: | Adults end-stage renal disease membranous nephropathy nephrotic syndrome proteinuria |
| Ano: | 2016 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Fundação para a Ciência e Tecnologia |
| Idioma: | inglês |
| Origem: | SciELO Portugal |
| _version_ | 1868441695436144640 |
|---|---|
| author | Hyder Rizvi,Syed Abbas |
| author2 | Naqvi,Rubina Ahmed,Ejaz Akhter,Fazal Abbas,Khawar Mubarak,Muhammed |
| author2_role | author author author author author |
| author_facet | Hyder Rizvi,Syed Abbas Naqvi,Rubina Ahmed,Ejaz Akhter,Fazal Abbas,Khawar Mubarak,Muhammed |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Hyder Rizvi,Syed Abbas\"},{\"Person.name\":\"Naqvi,Rubina\"},{\"Person.name\":\"Ahmed,Ejaz\"},{\"Person.name\":\"Akhter,Fazal\"},{\"Person.name\":\"Abbas,Khawar\"},{\"Person.name\":\"Mubarak,Muhammed\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Hyder Rizvi,Syed Abbas Naqvi,Rubina Ahmed,Ejaz Akhter,Fazal Abbas,Khawar Mubarak,Muhammed |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Adults end-stage renal disease membranous nephropathy nephrotic syndrome proteinuria |
| datacite.titles.title.fl_str_mv | Clinicopathological profile and prognosis of idiopathic membranous nephropathy in adults: a developing country perspective |
| dc.creator.none.fl_str_mv | Hyder Rizvi,Syed Abbas Naqvi,Rubina Ahmed,Ejaz Akhter,Fazal Abbas,Khawar Mubarak,Muhammed |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692016000200006 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Sociedade Portuguesa de Nefrologia |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | Portuguese Journal of Nephrology & Hypertension v.30 n.2 2016 |
| dc.subject.none.fl_str_mv | Adults end-stage renal disease membranous nephropathy nephrotic syndrome proteinuria |
| dc.title.fl_str_mv | Clinicopathological profile and prognosis of idiopathic membranous nephropathy in adults: a developing country perspective |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Background: There is no study available from Pakistan on the longitudinal course of membranous nephropathy (MN). We aimed to analyse the clinicopathological profile, course, response to treatment and outcome of the disease in our setup. Methods: All consecutive adult patients (≥18 years) with MN on renal biopsy and on regular follow-up were included. Relevant data items were retrieved from case files and biopsy reports. The outcome variables included doubling of baseline serum creatinine or the development of end-stage renal disease (ESRD). Results: Of a total of 102 patients, 82 (80.4%) were males; mean age was 28.9±11.4 years. Peripheral oedema was present in 86 (84.3%), nephrotic-range proteinuria in 80 (78.4%), microscopic haematuria in 25 (24.5%), hypertension in 42 (41.2%), and renal dysfunction in 13 (12.7%) patients at the time of presentation. The mean follow-up period was 3±2 years. Overall, 22 (21.5%) subjects went into remission and a similar number experienced doubling of serum creatinine. Both conservative and immunosuppressive treatment groups had similar duration of follow-up. The proportion of patients with remission and doubling of serum creatinine was similar between the two groups (p=0.70 and p=0.91 respectively), while the proportion of patients progressing to ESRD was significantly higher in the group treated conservatively (p=0.03). Baseline proteinuria and serum creatinine were predictive of remission (p=0.04 and p=0.05 respectively). Conclusions: In conclusion, untreated MN has a higher risk of progression to ESRD. Baseline proteinuria and serum creatinine predict response to treatment. Randomised controlled trials are needed to confirm the effects of immunosuppressive treatment |
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| eu_rights_str_mv | openAccess |
| format | article |
| id | scielopt_1c4f71e422ea41c3fbb76fba6f4170e2 |
| identifier.url.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692016000200006 |
| instacron_str | SciELO |
| institution | Fundação para a Ciência e Tecnologia |
| instname_str | Fundação para a Ciência e Tecnologia |
| language | eng |
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| network_name_str | SciELO Portugal |
| oai_identifier_str | oai:scielo:S0872-01692016000200006 |
| organization_str_mv | urn:organizationAcronym:scielo |
| person_str_mv | Hyder Rizvi,Syed Abbas Naqvi,Rubina Ahmed,Ejaz Akhter,Fazal Abbas,Khawar Mubarak,Muhammed |
| publishDate | 2016 |
| publisher.none.fl_str_mv | Sociedade Portuguesa de Nefrologia |
| reponame_str | SciELO Portugal |
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| spelling | Clinicopathological profile and prognosis of idiopathic membranous nephropathy in adults: a developing country perspectiveHyder Rizvi,Syed AbbasNaqvi,RubinaAhmed,EjazAkhter,FazalAbbas,KhawarMubarak,MuhammedAdultsend-stage renal diseasemembranous nephropathynephrotic syndromeproteinuriaopen accesshttp://purl.org/coar/access_right/c_abf2http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692016000200006URLhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692016000200006URLHasVersion2016-06-01Background: There is no study available from Pakistan on the longitudinal course of membranous nephropathy (MN). We aimed to analyse the clinicopathological profile, course, response to treatment and outcome of the disease in our setup. Methods: All consecutive adult patients (≥18 years) with MN on renal biopsy and on regular follow-up were included. Relevant data items were retrieved from case files and biopsy reports. The outcome variables included doubling of baseline serum creatinine or the development of end-stage renal disease (ESRD). Results: Of a total of 102 patients, 82 (80.4%) were males; mean age was 28.9±11.4 years. Peripheral oedema was present in 86 (84.3%), nephrotic-range proteinuria in 80 (78.4%), microscopic haematuria in 25 (24.5%), hypertension in 42 (41.2%), and renal dysfunction in 13 (12.7%) patients at the time of presentation. The mean follow-up period was 3±2 years. Overall, 22 (21.5%) subjects went into remission and a similar number experienced doubling of serum creatinine. Both conservative and immunosuppressive treatment groups had similar duration of follow-up. The proportion of patients with remission and doubling of serum creatinine was similar between the two groups (p=0.70 and p=0.91 respectively), while the proportion of patients progressing to ESRD was significantly higher in the group treated conservatively (p=0.03). Baseline proteinuria and serum creatinine were predictive of remission (p=0.04 and p=0.05 respectively). Conclusions: In conclusion, untreated MN has a higher risk of progression to ESRD. Baseline proteinuria and serum creatinine predict response to treatment. Randomised controlled trials are needed to confirm the effects of immunosuppressive treatmentSociedade Portuguesa de NefrologiaPortuguese Journal of Nephrology & Hypertension v.30 n.2 2016text/htmlengjournal articlehttp://purl.org/coar/resource_type/c_6501literature |
| spellingShingle | Clinicopathological profile and prognosis of idiopathic membranous nephropathy in adults: a developing country perspective Hyder Rizvi,Syed Abbas Adults end-stage renal disease membranous nephropathy nephrotic syndrome proteinuria |
| status | SINGLETON |
| subject.fl_str_mv | Adults end-stage renal disease membranous nephropathy nephrotic syndrome proteinuria |
| title | Clinicopathological profile and prognosis of idiopathic membranous nephropathy in adults: a developing country perspective |
| title_full | Clinicopathological profile and prognosis of idiopathic membranous nephropathy in adults: a developing country perspective |
| title_fullStr | Clinicopathological profile and prognosis of idiopathic membranous nephropathy in adults: a developing country perspective |
| title_full_unstemmed | Clinicopathological profile and prognosis of idiopathic membranous nephropathy in adults: a developing country perspective |
| title_short | Clinicopathological profile and prognosis of idiopathic membranous nephropathy in adults: a developing country perspective |
| title_sort | Clinicopathological profile and prognosis of idiopathic membranous nephropathy in adults: a developing country perspective |
| topic | Adults end-stage renal disease membranous nephropathy nephrotic syndrome proteinuria |
| topic_facet | Adults end-stage renal disease membranous nephropathy nephrotic syndrome proteinuria |
| url | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692016000200006 |
| visible | 1 |