Publicação
The gray area between operational tolerance and overt rejection in kidney transplantation
| Resumo: | ABSTRACT Operational tolerance in kidney transplantation is characterized by stable serum creatinine < 1.7 mg/dL and proteinuria < 1 g/day in the absence of immunosuppression or immunodeficiency for over one year. However, simultaneous donor specific antibodies are common and serum creatinine is a poor surrogate of early lesions. Consequently, subclinical rejections will meet operational tolerance criteria if sérum creatinine remains stable. We report a patient with operational tolerance criteria followed by biopsy-proven chronic active antibody mediated rejection, discussing the intricate challenges of immunosuppression management. |
|---|---|
| Autores principais: | Silva,Rui F. |
| Outros Autores: | Relvas,Miguel L.; Nunes,Ana; Silvano,José L.; Beco,Ana; Bustorff,Manuela B.; Sampaio,Susana M. |
| Assunto: | kidney transplantation operational tolerance antibody mediated rejection |
| Ano: | 2021 |
| País: | Portugal |
| Tipo de documento: | relatório |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Fundação para a Ciência e Tecnologia |
| Idioma: | português |
| Origem: | SciELO Portugal |
| _version_ | 1868441695876546560 |
|---|---|
| author | Silva,Rui F. |
| author2 | Relvas,Miguel L. Nunes,Ana Silvano,José L. Beco,Ana Bustorff,Manuela B. Sampaio,Susana M. |
| author2_role | author author author author author author |
| author_facet | Silva,Rui F. Relvas,Miguel L. Nunes,Ana Silvano,José L. Beco,Ana Bustorff,Manuela B. Sampaio,Susana M. |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Silva,Rui F.\"},{\"Person.name\":\"Relvas,Miguel L.\"},{\"Person.name\":\"Nunes,Ana\"},{\"Person.name\":\"Silvano,José L.\"},{\"Person.name\":\"Beco,Ana\"},{\"Person.name\":\"Bustorff,Manuela B.\"},{\"Person.name\":\"Sampaio,Susana M.\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Silva,Rui F. Relvas,Miguel L. Nunes,Ana Silvano,José L. Beco,Ana Bustorff,Manuela B. Sampaio,Susana M. |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | kidney transplantation operational tolerance antibody mediated rejection |
| datacite.titles.title.fl_str_mv | The gray area between operational tolerance and overt rejection in kidney transplantation |
| dc.creator.none.fl_str_mv | Silva,Rui F. Relvas,Miguel L. Nunes,Ana Silvano,José L. Beco,Ana Bustorff,Manuela B. Sampaio,Susana M. |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000400260 |
| dc.language.none.fl_str_mv | por |
| dc.publisher.none.fl_str_mv | Sociedade Portuguesa de Nefrologia |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | Portuguese Journal of Nephrology & Hypertension v.35 n.4 2021 |
| dc.subject.none.fl_str_mv | kidney transplantation operational tolerance antibody mediated rejection |
| dc.title.fl_str_mv | The gray area between operational tolerance and overt rejection in kidney transplantation |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_93fc |
| description | ABSTRACT Operational tolerance in kidney transplantation is characterized by stable serum creatinine < 1.7 mg/dL and proteinuria < 1 g/day in the absence of immunosuppression or immunodeficiency for over one year. However, simultaneous donor specific antibodies are common and serum creatinine is a poor surrogate of early lesions. Consequently, subclinical rejections will meet operational tolerance criteria if sérum creatinine remains stable. We report a patient with operational tolerance criteria followed by biopsy-proven chronic active antibody mediated rejection, discussing the intricate challenges of immunosuppression management. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | report |
| id | scielopt_2efb94d5341dfc5615d1ec0028aa39ad |
| identifier.url.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000400260 |
| instacron_str | SciELO |
| institution | Fundação para a Ciência e Tecnologia |
| instname_str | Fundação para a Ciência e Tecnologia |
| language | por |
| network_acronym_str | scielopt |
| network_name_str | SciELO Portugal |
| oai_identifier_str | oai:scielo:S0872-01692021000400260 |
| organization_str_mv | urn:organizationAcronym:scielo |
| person_str_mv | Silva,Rui F. Relvas,Miguel L. Nunes,Ana Silvano,José L. Beco,Ana Bustorff,Manuela B. Sampaio,Susana M. |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Sociedade Portuguesa de Nefrologia |
| reponame_str | SciELO Portugal |
| repository_id_str | urn:repositoryAcronym:scielopt |
| service_str_mv | urn:repositoryAcronym:scielopt |
| spelling | The gray area between operational tolerance and overt rejection in kidney transplantationSilva,Rui F.Relvas,Miguel L.Nunes,AnaSilvano,José L.Beco,AnaBustorff,Manuela B.Sampaio,Susana M.kidney transplantationoperational toleranceantibody mediated rejectionopen accesshttp://purl.org/coar/access_right/c_abf2http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000400260URLhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000400260URLHasVersion2021-12-01ABSTRACT Operational tolerance in kidney transplantation is characterized by stable serum creatinine < 1.7 mg/dL and proteinuria < 1 g/day in the absence of immunosuppression or immunodeficiency for over one year. However, simultaneous donor specific antibodies are common and serum creatinine is a poor surrogate of early lesions. Consequently, subclinical rejections will meet operational tolerance criteria if sérum creatinine remains stable. We report a patient with operational tolerance criteria followed by biopsy-proven chronic active antibody mediated rejection, discussing the intricate challenges of immunosuppression management.Sociedade Portuguesa de NefrologiaPortuguese Journal of Nephrology & Hypertension v.35 n.4 2021text/htmlporreporthttp://purl.org/coar/resource_type/c_93fcother research product |
| spellingShingle | The gray area between operational tolerance and overt rejection in kidney transplantation Silva,Rui F. kidney transplantation operational tolerance antibody mediated rejection |
| status | SINGLETON |
| subject.fl_str_mv | kidney transplantation operational tolerance antibody mediated rejection |
| title | The gray area between operational tolerance and overt rejection in kidney transplantation |
| title_full | The gray area between operational tolerance and overt rejection in kidney transplantation |
| title_fullStr | The gray area between operational tolerance and overt rejection in kidney transplantation |
| title_full_unstemmed | The gray area between operational tolerance and overt rejection in kidney transplantation |
| title_short | The gray area between operational tolerance and overt rejection in kidney transplantation |
| title_sort | The gray area between operational tolerance and overt rejection in kidney transplantation |
| topic | kidney transplantation operational tolerance antibody mediated rejection |
| topic_facet | kidney transplantation operational tolerance antibody mediated rejection |
| url | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000400260 |
| visible | 1 |