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SARS-CoV-2 Antibody Response to Vaccination in Peritoneal Dialysis Patients

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Resumo:ABSTRACT Introduction: Chronic kidney disease patients have a higher risk of infection and worse clinical outcomes after coronavirus disease. We aimed to assess the prevalence of infection and the humoral response after vaccination in peritoneal dialysis patients. Methods: Three types of vaccines were administered (two doses) with the antibody detection at least six months after. Coronavirus disease 2019 infections, hospital admissions, and deaths were evaluated. Results: From 70 prevalent patients, 45 were included. There was a significant increase in antibody level, with a median of 92 (36, 447) U/mL. Only 4% of patients remained seronegative. History of immunosuppressive therapy was associated with no response (100% vs 60%, p=0.010). There were two infections after the vaccination, without hospital admission. Conclusion: Immunization against coronavirus disease was effective in generating a humoral response in peritoneal dialysis patients. There was also an evident impact of immunosuppressive therapy on vaccine response in peritoneal dialysis patients.
Autores principais:Donato*,Beatriz
Outros Autores:Mateus*,Catarina; Roxo,Maria Inês; Duarte,Carlos Pereira; Calça,Rita Ribeiro; Matias,Patrícia João; Branco,Patrícia
Assunto:COVID-19 COVID-19 Vaccines Immunity, Humoral Kidney Failure, Chronic Peritoneal Dialysis SARS-CoV-2
Ano:2023
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Fundação para a Ciência e Tecnologia
Idioma:inglês
Origem:SciELO Portugal

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