Publicação
Immunoglobulin A vasculitis (Henoch-Schönlein purpura) in children - A Literature Review
| Resumo: | Abstract Immunoglobulin A vasculitis (IgAV) is a small-vessel vasculitis that primarily affects children. Major manifestations include purpuric rash, proteinuria/hematuria, arthralgia, and abdominal pain. In this article, the authors review data on the epidemiology, diagnosis, and treatment of IgAV in children. IgAV affects 10 to 56 children per 100,000 per year. The mean age at presentation is six years. Both genetic and environmental factors contribute to its pathogenesis, but the deposition of immune complexes containing abnormal glycosylated immunoglobulin (Ig) A1 plays a predominant role. The course of the disease is usually benign and supportive care is sufficient. Short-term complications are mostly related to gastrointestinal involvement, including the risk of perforation and bleeding. Long-term morbidity is due to chronic kidney disease and hypertension. Corticosteroids are not recommended for prevention of renal involvement, but may be useful as a treatment strategy, as well as more aggressive immunosuppressive drugs. |
|---|---|
| Autores principais: | Sousa,Patrícia |
| Outros Autores: | Oliveira,Susana Correia de; Dias,Ângela; Tavares,Cláudia |
| Assunto: | child diagnosis epidemiology IgA vasculitis physiopathology therapy |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Fundação para a Ciência e Tecnologia |
| Idioma: | inglês |
| Origem: | SciELO Portugal |
| _version_ | 1868441710487404544 |
|---|---|
| author | Sousa,Patrícia |
| author2 | Oliveira,Susana Correia de Dias,Ângela Tavares,Cláudia |
| author2_role | author author author |
| author_facet | Sousa,Patrícia Oliveira,Susana Correia de Dias,Ângela Tavares,Cláudia |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Sousa,Patrícia\"},{\"Person.name\":\"Oliveira,Susana Correia de\"},{\"Person.name\":\"Dias,Ângela\"},{\"Person.name\":\"Tavares,Cláudia\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Sousa,Patrícia Oliveira,Susana Correia de Dias,Ângela Tavares,Cláudia |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | child diagnosis epidemiology IgA vasculitis physiopathology therapy |
| datacite.titles.title.fl_str_mv | Immunoglobulin A vasculitis (Henoch-Schönlein purpura) in children - A Literature Review |
| dc.creator.none.fl_str_mv | Sousa,Patrícia Oliveira,Susana Correia de Dias,Ângela Tavares,Cláudia |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000300205 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Centro Hospitalar do Porto |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | Nascer e Crescer v.32 n.3 2023 |
| dc.subject.none.fl_str_mv | child diagnosis epidemiology IgA vasculitis physiopathology therapy |
| dc.title.fl_str_mv | Immunoglobulin A vasculitis (Henoch-Schönlein purpura) in children - A Literature Review |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Abstract Immunoglobulin A vasculitis (IgAV) is a small-vessel vasculitis that primarily affects children. Major manifestations include purpuric rash, proteinuria/hematuria, arthralgia, and abdominal pain. In this article, the authors review data on the epidemiology, diagnosis, and treatment of IgAV in children. IgAV affects 10 to 56 children per 100,000 per year. The mean age at presentation is six years. Both genetic and environmental factors contribute to its pathogenesis, but the deposition of immune complexes containing abnormal glycosylated immunoglobulin (Ig) A1 plays a predominant role. The course of the disease is usually benign and supportive care is sufficient. Short-term complications are mostly related to gastrointestinal involvement, including the risk of perforation and bleeding. Long-term morbidity is due to chronic kidney disease and hypertension. Corticosteroids are not recommended for prevention of renal involvement, but may be useful as a treatment strategy, as well as more aggressive immunosuppressive drugs. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| id | scielopt_586ddcbd47225a3834bf75c8b7ad2356 |
| identifier.url.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000300205 |
| instacron_str | SciELO |
| institution | Fundação para a Ciência e Tecnologia |
| instname_str | Fundação para a Ciência e Tecnologia |
| language | eng |
| network_acronym_str | scielopt |
| network_name_str | SciELO Portugal |
| oai_identifier_str | oai:scielo:S0872-07542023000300205 |
| organization_str_mv | urn:organizationAcronym:scielo |
| person_str_mv | Sousa,Patrícia Oliveira,Susana Correia de Dias,Ângela Tavares,Cláudia |
| publishDate | 2023 |
| publisher.none.fl_str_mv | Centro Hospitalar do Porto |
| reponame_str | SciELO Portugal |
| repository_id_str | urn:repositoryAcronym:scielopt |
| service_str_mv | urn:repositoryAcronym:scielopt |
| spelling | Immunoglobulin A vasculitis (Henoch-Schönlein purpura) in children - A Literature ReviewSousa,PatríciaOliveira,Susana Correia deDias,ÂngelaTavares,CláudiachilddiagnosisepidemiologyIgA vasculitisphysiopathologytherapyopen accesshttp://purl.org/coar/access_right/c_abf2http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000300205URLhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000300205URLHasVersion2023-09-01Abstract Immunoglobulin A vasculitis (IgAV) is a small-vessel vasculitis that primarily affects children. Major manifestations include purpuric rash, proteinuria/hematuria, arthralgia, and abdominal pain. In this article, the authors review data on the epidemiology, diagnosis, and treatment of IgAV in children. IgAV affects 10 to 56 children per 100,000 per year. The mean age at presentation is six years. Both genetic and environmental factors contribute to its pathogenesis, but the deposition of immune complexes containing abnormal glycosylated immunoglobulin (Ig) A1 plays a predominant role. The course of the disease is usually benign and supportive care is sufficient. Short-term complications are mostly related to gastrointestinal involvement, including the risk of perforation and bleeding. Long-term morbidity is due to chronic kidney disease and hypertension. Corticosteroids are not recommended for prevention of renal involvement, but may be useful as a treatment strategy, as well as more aggressive immunosuppressive drugs.Centro Hospitalar do PortoNascer e Crescer v.32 n.3 2023text/htmlengjournal articlehttp://purl.org/coar/resource_type/c_6501literature |
| spellingShingle | Immunoglobulin A vasculitis (Henoch-Schönlein purpura) in children - A Literature Review Sousa,Patrícia child diagnosis epidemiology IgA vasculitis physiopathology therapy |
| status | SINGLETON |
| subject.fl_str_mv | child diagnosis epidemiology IgA vasculitis physiopathology therapy |
| title | Immunoglobulin A vasculitis (Henoch-Schönlein purpura) in children - A Literature Review |
| title_full | Immunoglobulin A vasculitis (Henoch-Schönlein purpura) in children - A Literature Review |
| title_fullStr | Immunoglobulin A vasculitis (Henoch-Schönlein purpura) in children - A Literature Review |
| title_full_unstemmed | Immunoglobulin A vasculitis (Henoch-Schönlein purpura) in children - A Literature Review |
| title_short | Immunoglobulin A vasculitis (Henoch-Schönlein purpura) in children - A Literature Review |
| title_sort | Immunoglobulin A vasculitis (Henoch-Schönlein purpura) in children - A Literature Review |
| topic | child diagnosis epidemiology IgA vasculitis physiopathology therapy |
| topic_facet | child diagnosis epidemiology IgA vasculitis physiopathology therapy |
| url | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-07542023000300205 |
| visible | 1 |