Publicação
Impact of pre-transplant anti-MICA sensitization in graft rejection and survival
| Resumo: | Background: Evidence supporting deleterious effect of preformed major histocompatibility class I chain-related A (MICA) antibodies in rejection incidence and graft survival is still unclear. Methods: Retrospective analysis of 554 kidney transplanted patients. Comparison between positive or negative for MICA antibodies patients was performed to characterize sensitizing triggers. Further classification according to pre-transplant flow cytometry-recorded anti-MICA and/or anti-human leukocyte antigen (HLA) antibodies was made to determine first year rejection incidence and graft survival. Multivariate analysis was applied to determine predictors for acute rejection. Results: Pre-formed anti-MICA antibodies were detected in 41 patients (7.4%). HLA sensitization, blood transfusions and pregnancies were frequently found in anti-MICA+ patients but only pre-formed anti-HLA class I antibodies showed independent association (OR 2.67, p = 0.02). Comparing to MICA-/HLA-, MICA-/HLA+ group presented significantly lower first year rejection-free survival (78.6% vs. 89.3%, p < 0.01), mostly occurred in the first six months, while no difference was found in MICA+/HLA- (88.9% vs. 89.3%, p = ns). MICA-/HLA+ showed independent impact in rejection (OR 2.09, p = 0.03), while no evidence was found in MICA+/HLA- (OR 1.08, p = ns). At 4 years, MICA-/HLA+ group presented lower graft survival (85.8% vs. 95.3%, p = 0.03). Again, no difference was found in MICA+/HLA- group (95.1% vs. 95.3%, p = ns). Conclusion: Our results do not support HLA-independent deleterious pathogenic role of pre-formed MICA antibodies on first year rejection incidence and graft survival |
|---|---|
| Autores principais: | Costa,Rui |
| Outros Autores: | Malheiro,Jorge; Tafulo,Sandra; Santos,Clara; Almeida,Manuela; Pedroso,Sofia; Martins,La Salete; Dias,Leonídio; Castro-Henriques,António |
| Assunto: | HLA kidney MICA rejection survival transplant |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Fundação para a Ciência e Tecnologia |
| Idioma: | inglês |
| Origem: | SciELO Portugal |
| _version_ | 1868441695350161408 |
|---|---|
| author | Costa,Rui |
| author2 | Malheiro,Jorge Tafulo,Sandra Santos,Clara Almeida,Manuela Pedroso,Sofia Martins,La Salete Dias,Leonídio Castro-Henriques,António |
| author2_role | author author author author author author author author |
| author_facet | Costa,Rui Malheiro,Jorge Tafulo,Sandra Santos,Clara Almeida,Manuela Pedroso,Sofia Martins,La Salete Dias,Leonídio Castro-Henriques,António |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Costa,Rui\"},{\"Person.name\":\"Malheiro,Jorge\"},{\"Person.name\":\"Tafulo,Sandra\"},{\"Person.name\":\"Santos,Clara\"},{\"Person.name\":\"Almeida,Manuela\"},{\"Person.name\":\"Pedroso,Sofia\"},{\"Person.name\":\"Martins,La Salete\"},{\"Person.name\":\"Dias,Leonídio\"},{\"Person.name\":\"Castro-Henriques,António\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Costa,Rui Malheiro,Jorge Tafulo,Sandra Santos,Clara Almeida,Manuela Pedroso,Sofia Martins,La Salete Dias,Leonídio Castro-Henriques,António |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | HLA kidney MICA rejection survival transplant |
| datacite.titles.title.fl_str_mv | Impact of pre-transplant anti-MICA sensitization in graft rejection and survival |
| dc.creator.none.fl_str_mv | Costa,Rui Malheiro,Jorge Tafulo,Sandra Santos,Clara Almeida,Manuela Pedroso,Sofia Martins,La Salete Dias,Leonídio Castro-Henriques,António |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000200005 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Sociedade Portuguesa de Nefrologia |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | Portuguese Journal of Nephrology & Hypertension v.29 n.2 2015 |
| dc.subject.none.fl_str_mv | HLA kidney MICA rejection survival transplant |
| dc.title.fl_str_mv | Impact of pre-transplant anti-MICA sensitization in graft rejection and survival |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Background: Evidence supporting deleterious effect of preformed major histocompatibility class I chain-related A (MICA) antibodies in rejection incidence and graft survival is still unclear. Methods: Retrospective analysis of 554 kidney transplanted patients. Comparison between positive or negative for MICA antibodies patients was performed to characterize sensitizing triggers. Further classification according to pre-transplant flow cytometry-recorded anti-MICA and/or anti-human leukocyte antigen (HLA) antibodies was made to determine first year rejection incidence and graft survival. Multivariate analysis was applied to determine predictors for acute rejection. Results: Pre-formed anti-MICA antibodies were detected in 41 patients (7.4%). HLA sensitization, blood transfusions and pregnancies were frequently found in anti-MICA+ patients but only pre-formed anti-HLA class I antibodies showed independent association (OR 2.67, p = 0.02). Comparing to MICA-/HLA-, MICA-/HLA+ group presented significantly lower first year rejection-free survival (78.6% vs. 89.3%, p < 0.01), mostly occurred in the first six months, while no difference was found in MICA+/HLA- (88.9% vs. 89.3%, p = ns). MICA-/HLA+ showed independent impact in rejection (OR 2.09, p = 0.03), while no evidence was found in MICA+/HLA- (OR 1.08, p = ns). At 4 years, MICA-/HLA+ group presented lower graft survival (85.8% vs. 95.3%, p = 0.03). Again, no difference was found in MICA+/HLA- group (95.1% vs. 95.3%, p = ns). Conclusion: Our results do not support HLA-independent deleterious pathogenic role of pre-formed MICA antibodies on first year rejection incidence and graft survival |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| id | scielopt_5c2ded9b4bb401f29f89aa48cd656021 |
| identifier.url.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000200005 |
| instacron_str | SciELO |
| institution | Fundação para a Ciência e Tecnologia |
| instname_str | Fundação para a Ciência e Tecnologia |
| language | eng |
| network_acronym_str | scielopt |
| network_name_str | SciELO Portugal |
| oai_identifier_str | oai:scielo:S0872-01692015000200005 |
| organization_str_mv | urn:organizationAcronym:scielo |
| person_str_mv | Costa,Rui Malheiro,Jorge Tafulo,Sandra Santos,Clara Almeida,Manuela Pedroso,Sofia Martins,La Salete Dias,Leonídio Castro-Henriques,António |
| publishDate | 2015 |
| publisher.none.fl_str_mv | Sociedade Portuguesa de Nefrologia |
| reponame_str | SciELO Portugal |
| repository_id_str | urn:repositoryAcronym:scielopt |
| service_str_mv | urn:repositoryAcronym:scielopt |
| spelling | Impact of pre-transplant anti-MICA sensitization in graft rejection and survivalCosta,RuiMalheiro,JorgeTafulo,SandraSantos,ClaraAlmeida,ManuelaPedroso,SofiaMartins,La SaleteDias,LeonídioCastro-Henriques,AntónioHLAkidneyMICArejectionsurvivaltransplantopen accesshttp://purl.org/coar/access_right/c_abf2http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000200005URLhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000200005URLHasVersion2015-06-01Background: Evidence supporting deleterious effect of preformed major histocompatibility class I chain-related A (MICA) antibodies in rejection incidence and graft survival is still unclear. Methods: Retrospective analysis of 554 kidney transplanted patients. Comparison between positive or negative for MICA antibodies patients was performed to characterize sensitizing triggers. Further classification according to pre-transplant flow cytometry-recorded anti-MICA and/or anti-human leukocyte antigen (HLA) antibodies was made to determine first year rejection incidence and graft survival. Multivariate analysis was applied to determine predictors for acute rejection. Results: Pre-formed anti-MICA antibodies were detected in 41 patients (7.4%). HLA sensitization, blood transfusions and pregnancies were frequently found in anti-MICA+ patients but only pre-formed anti-HLA class I antibodies showed independent association (OR 2.67, p = 0.02). Comparing to MICA-/HLA-, MICA-/HLA+ group presented significantly lower first year rejection-free survival (78.6% vs. 89.3%, p < 0.01), mostly occurred in the first six months, while no difference was found in MICA+/HLA- (88.9% vs. 89.3%, p = ns). MICA-/HLA+ showed independent impact in rejection (OR 2.09, p = 0.03), while no evidence was found in MICA+/HLA- (OR 1.08, p = ns). At 4 years, MICA-/HLA+ group presented lower graft survival (85.8% vs. 95.3%, p = 0.03). Again, no difference was found in MICA+/HLA- group (95.1% vs. 95.3%, p = ns). Conclusion: Our results do not support HLA-independent deleterious pathogenic role of pre-formed MICA antibodies on first year rejection incidence and graft survivalSociedade Portuguesa de NefrologiaPortuguese Journal of Nephrology & Hypertension v.29 n.2 2015text/htmlengjournal articlehttp://purl.org/coar/resource_type/c_6501literature |
| spellingShingle | Impact of pre-transplant anti-MICA sensitization in graft rejection and survival Costa,Rui HLA kidney MICA rejection survival transplant |
| status | SINGLETON |
| subject.fl_str_mv | HLA kidney MICA rejection survival transplant |
| title | Impact of pre-transplant anti-MICA sensitization in graft rejection and survival |
| title_full | Impact of pre-transplant anti-MICA sensitization in graft rejection and survival |
| title_fullStr | Impact of pre-transplant anti-MICA sensitization in graft rejection and survival |
| title_full_unstemmed | Impact of pre-transplant anti-MICA sensitization in graft rejection and survival |
| title_short | Impact of pre-transplant anti-MICA sensitization in graft rejection and survival |
| title_sort | Impact of pre-transplant anti-MICA sensitization in graft rejection and survival |
| topic | HLA kidney MICA rejection survival transplant |
| topic_facet | HLA kidney MICA rejection survival transplant |
| url | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000200005 |
| visible | 1 |