Publicação
Improvement of Central Nervous System Vasculitis in a Patient with Chronic Hepatitis C Virus Infection after Treatment with an Interferon-Free Regimen
| Resumo: | Background: Neurosarcoidosis is a rare manifestation of hepatitis C virus (HCV) infection, mainly in patients exposed to interferon-based therapies. Although we are living in a new era of HCV treatment, there is still little data concerning the treatment of extrahepatic complications of the disease with direct antiviral agents, especially rare ones such as neurosarcoidosis. Summary: We present a rare case of central nervous system vasculitic lesions in the context of chronic HCV infection associated with mixed cryoglobulinemia, elevated angiotensin-converting enzyme (ACE) levels, and documentation of viral RNA in the cerebrospinal fluid in a treatment-naïve chronic HCV patient. Successful treatment with an interferon-free regimen improved all clinical manifestations, reduced the levels of serum ACE, and reduced the cryoglobulin levels to undetectable. Messages: Neurosarcoidosis and cryoglobulinemia are rare but well-recognized complications of HCV infection, even in treatment-naïve patients. Direct antiviral agents can be useful in the management of this condition. |
|---|---|
| Autores principais: | Lima,Sérgio |
| Outros Autores: | Faria,Raquel; Nery,Filipe |
| Assunto: | Hepatitis C virus infection Neurosarcoidosis Central nervous system vasculitis Direct antiviral agents Cryoglobulinemia |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | relatório |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Fundação para a Ciência e Tecnologia |
| Idioma: | inglês |
| Origem: | SciELO Portugal |
| _version_ | 1868441987938516992 |
|---|---|
| author | Lima,Sérgio |
| author2 | Faria,Raquel Nery,Filipe |
| author2_role | author author |
| author_facet | Lima,Sérgio Faria,Raquel Nery,Filipe |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Lima,Sérgio\"},{\"Person.name\":\"Faria,Raquel\"},{\"Person.name\":\"Nery,Filipe\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Lima,Sérgio Faria,Raquel Nery,Filipe |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Hepatitis C virus infection Neurosarcoidosis Central nervous system vasculitis Direct antiviral agents Cryoglobulinemia |
| datacite.titles.title.fl_str_mv | Improvement of Central Nervous System Vasculitis in a Patient with Chronic Hepatitis C Virus Infection after Treatment with an Interferon-Free Regimen |
| dc.creator.none.fl_str_mv | Lima,Sérgio Faria,Raquel Nery,Filipe |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452019000400008 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Sociedade Portuguesa de Gastrenterologia |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | GE-Portuguese Journal of Gastroenterology v.26 n.4 2019 |
| dc.subject.none.fl_str_mv | Hepatitis C virus infection Neurosarcoidosis Central nervous system vasculitis Direct antiviral agents Cryoglobulinemia |
| dc.title.fl_str_mv | Improvement of Central Nervous System Vasculitis in a Patient with Chronic Hepatitis C Virus Infection after Treatment with an Interferon-Free Regimen |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_93fc |
| description | Background: Neurosarcoidosis is a rare manifestation of hepatitis C virus (HCV) infection, mainly in patients exposed to interferon-based therapies. Although we are living in a new era of HCV treatment, there is still little data concerning the treatment of extrahepatic complications of the disease with direct antiviral agents, especially rare ones such as neurosarcoidosis. Summary: We present a rare case of central nervous system vasculitic lesions in the context of chronic HCV infection associated with mixed cryoglobulinemia, elevated angiotensin-converting enzyme (ACE) levels, and documentation of viral RNA in the cerebrospinal fluid in a treatment-naïve chronic HCV patient. Successful treatment with an interferon-free regimen improved all clinical manifestations, reduced the levels of serum ACE, and reduced the cryoglobulin levels to undetectable. Messages: Neurosarcoidosis and cryoglobulinemia are rare but well-recognized complications of HCV infection, even in treatment-naïve patients. Direct antiviral agents can be useful in the management of this condition. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | report |
| id | scielopt_655be07ad5eaf7df656d46fd5db5b563 |
| identifier.url.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452019000400008 |
| instacron_str | SciELO |
| institution | Fundação para a Ciência e Tecnologia |
| instname_str | Fundação para a Ciência e Tecnologia |
| language | eng |
| network_acronym_str | scielopt |
| network_name_str | SciELO Portugal |
| oai_identifier_str | oai:scielo:S2341-45452019000400008 |
| organization_str_mv | urn:organizationAcronym:scielo |
| person_str_mv | Lima,Sérgio Faria,Raquel Nery,Filipe |
| publishDate | 2019 |
| publisher.none.fl_str_mv | Sociedade Portuguesa de Gastrenterologia |
| reponame_str | SciELO Portugal |
| repository_id_str | urn:repositoryAcronym:scielopt |
| service_str_mv | urn:repositoryAcronym:scielopt |
| spelling | Improvement of Central Nervous System Vasculitis in a Patient with Chronic Hepatitis C Virus Infection after Treatment with an Interferon-Free RegimenLima,SérgioFaria,RaquelNery,FilipeHepatitis C virus infectionNeurosarcoidosisCentral nervous system vasculitisDirect antiviral agentsCryoglobulinemiaopen accesshttp://purl.org/coar/access_right/c_abf2http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452019000400008URLhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452019000400008URLHasVersion2019-08-01Background: Neurosarcoidosis is a rare manifestation of hepatitis C virus (HCV) infection, mainly in patients exposed to interferon-based therapies. Although we are living in a new era of HCV treatment, there is still little data concerning the treatment of extrahepatic complications of the disease with direct antiviral agents, especially rare ones such as neurosarcoidosis. Summary: We present a rare case of central nervous system vasculitic lesions in the context of chronic HCV infection associated with mixed cryoglobulinemia, elevated angiotensin-converting enzyme (ACE) levels, and documentation of viral RNA in the cerebrospinal fluid in a treatment-naïve chronic HCV patient. Successful treatment with an interferon-free regimen improved all clinical manifestations, reduced the levels of serum ACE, and reduced the cryoglobulin levels to undetectable. Messages: Neurosarcoidosis and cryoglobulinemia are rare but well-recognized complications of HCV infection, even in treatment-naïve patients. Direct antiviral agents can be useful in the management of this condition.Sociedade Portuguesa de GastrenterologiaGE-Portuguese Journal of Gastroenterology v.26 n.4 2019text/htmlengreporthttp://purl.org/coar/resource_type/c_93fcother research product |
| spellingShingle | Improvement of Central Nervous System Vasculitis in a Patient with Chronic Hepatitis C Virus Infection after Treatment with an Interferon-Free Regimen Lima,Sérgio Hepatitis C virus infection Neurosarcoidosis Central nervous system vasculitis Direct antiviral agents Cryoglobulinemia |
| status | SINGLETON |
| subject.fl_str_mv | Hepatitis C virus infection Neurosarcoidosis Central nervous system vasculitis Direct antiviral agents Cryoglobulinemia |
| title | Improvement of Central Nervous System Vasculitis in a Patient with Chronic Hepatitis C Virus Infection after Treatment with an Interferon-Free Regimen |
| title_full | Improvement of Central Nervous System Vasculitis in a Patient with Chronic Hepatitis C Virus Infection after Treatment with an Interferon-Free Regimen |
| title_fullStr | Improvement of Central Nervous System Vasculitis in a Patient with Chronic Hepatitis C Virus Infection after Treatment with an Interferon-Free Regimen |
| title_full_unstemmed | Improvement of Central Nervous System Vasculitis in a Patient with Chronic Hepatitis C Virus Infection after Treatment with an Interferon-Free Regimen |
| title_short | Improvement of Central Nervous System Vasculitis in a Patient with Chronic Hepatitis C Virus Infection after Treatment with an Interferon-Free Regimen |
| title_sort | Improvement of Central Nervous System Vasculitis in a Patient with Chronic Hepatitis C Virus Infection after Treatment with an Interferon-Free Regimen |
| topic | Hepatitis C virus infection Neurosarcoidosis Central nervous system vasculitis Direct antiviral agents Cryoglobulinemia |
| topic_facet | Hepatitis C virus infection Neurosarcoidosis Central nervous system vasculitis Direct antiviral agents Cryoglobulinemia |
| url | http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452019000400008 |
| visible | 1 |