Publicação
Anti-phospholipase A2 receptor antibodies in the diagnosis of idiopathic membranous nephropathy
| Resumo: | Circulating anti-phospholipase A2 receptor antibodies (anti-PLA2R) have been described in 70% to 80% of the patients with idiopathic membranous nephropathy (iMN), but not in patients with secondary membranous nephropathy or other glomerular diseases. The goal of this study was to evaluate the sensitivity and specificity of the assay for anti-PLA2R in the diagnosis of iMN. Anti-PLA2R IgG, Elisa and immunofluorescence tests were used to detect circulating anti-PLA2R. These tests were applied in 53 patients who had a kidney biopsy. Of these, 38 had histological diagnosis of membranous nephropathy (MN) and the remaining had other glomerular diseases. The MN was classified as idiopathic in 33 patients after clinical exclusion of secondary causes. Anti-PLA2R were positive in 57.6% of the patients with iMN. All patients with secondary membranous nephropathy or other glomerular diseases did not show circulating anti-PLA2R. The sensitivity was 57.6% (CI 39.2-74.5) and specificity 100% (CI 47.8-100), AUC 0.788; p < 0.0001 for the detection of iMN. 71.4% of the iMN patients that tested negative for anti-PLA2R were in partial or complete remission. The detection of anti-PLA2R in the studied population had a specificity of 100% for the iMN diagnosis. Prior treatments seem to make the test negative and contribute to a lower sensitivity |
|---|---|
| Autores principais: | Meneses,Guida |
| Outros Autores: | Viana,Helena; Santos,Maria C.; Ferreira,Carina; Calado,Joaquim; Carvalho,Fernanda; Remedio,Francisco; Nolasco,Fernando |
| Assunto: | Anti-phospholipase A2 receptor idiopathic membranous nephropathy nephrotic syndrome podocyte |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Fundação para a Ciência e Tecnologia |
| Idioma: | inglês |
| Origem: | SciELO Portugal |
| _version_ | 1868441695330238464 |
|---|---|
| author | Meneses,Guida |
| author2 | Viana,Helena Santos,Maria C. Ferreira,Carina Calado,Joaquim Carvalho,Fernanda Remedio,Francisco Nolasco,Fernando |
| author2_role | author author author author author author author |
| author_facet | Meneses,Guida Viana,Helena Santos,Maria C. Ferreira,Carina Calado,Joaquim Carvalho,Fernanda Remedio,Francisco Nolasco,Fernando |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Meneses,Guida\"},{\"Person.name\":\"Viana,Helena\"},{\"Person.name\":\"Santos,Maria C.\"},{\"Person.name\":\"Ferreira,Carina\"},{\"Person.name\":\"Calado,Joaquim\"},{\"Person.name\":\"Carvalho,Fernanda\"},{\"Person.name\":\"Remedio,Francisco\"},{\"Person.name\":\"Nolasco,Fernando\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Meneses,Guida Viana,Helena Santos,Maria C. Ferreira,Carina Calado,Joaquim Carvalho,Fernanda Remedio,Francisco Nolasco,Fernando |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Anti-phospholipase A2 receptor idiopathic membranous nephropathy nephrotic syndrome podocyte |
| datacite.titles.title.fl_str_mv | Anti-phospholipase A2 receptor antibodies in the diagnosis of idiopathic membranous nephropathy |
| dc.creator.none.fl_str_mv | Meneses,Guida Viana,Helena Santos,Maria C. Ferreira,Carina Calado,Joaquim Carvalho,Fernanda Remedio,Francisco Nolasco,Fernando |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000100008 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Sociedade Portuguesa de Nefrologia |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | Portuguese Journal of Nephrology & Hypertension v.29 n.1 2015 |
| dc.subject.none.fl_str_mv | Anti-phospholipase A2 receptor idiopathic membranous nephropathy nephrotic syndrome podocyte |
| dc.title.fl_str_mv | Anti-phospholipase A2 receptor antibodies in the diagnosis of idiopathic membranous nephropathy |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Circulating anti-phospholipase A2 receptor antibodies (anti-PLA2R) have been described in 70% to 80% of the patients with idiopathic membranous nephropathy (iMN), but not in patients with secondary membranous nephropathy or other glomerular diseases. The goal of this study was to evaluate the sensitivity and specificity of the assay for anti-PLA2R in the diagnosis of iMN. Anti-PLA2R IgG, Elisa and immunofluorescence tests were used to detect circulating anti-PLA2R. These tests were applied in 53 patients who had a kidney biopsy. Of these, 38 had histological diagnosis of membranous nephropathy (MN) and the remaining had other glomerular diseases. The MN was classified as idiopathic in 33 patients after clinical exclusion of secondary causes. Anti-PLA2R were positive in 57.6% of the patients with iMN. All patients with secondary membranous nephropathy or other glomerular diseases did not show circulating anti-PLA2R. The sensitivity was 57.6% (CI 39.2-74.5) and specificity 100% (CI 47.8-100), AUC 0.788; p < 0.0001 for the detection of iMN. 71.4% of the iMN patients that tested negative for anti-PLA2R were in partial or complete remission. The detection of anti-PLA2R in the studied population had a specificity of 100% for the iMN diagnosis. Prior treatments seem to make the test negative and contribute to a lower sensitivity |
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| format | article |
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| identifier.url.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000100008 |
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| institution | Fundação para a Ciência e Tecnologia |
| instname_str | Fundação para a Ciência e Tecnologia |
| language | eng |
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| person_str_mv | Meneses,Guida Viana,Helena Santos,Maria C. Ferreira,Carina Calado,Joaquim Carvalho,Fernanda Remedio,Francisco Nolasco,Fernando |
| publishDate | 2015 |
| publisher.none.fl_str_mv | Sociedade Portuguesa de Nefrologia |
| reponame_str | SciELO Portugal |
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| spelling | Anti-phospholipase A2 receptor antibodies in the diagnosis of idiopathic membranous nephropathyMeneses,GuidaViana,HelenaSantos,Maria C.Ferreira,CarinaCalado,JoaquimCarvalho,FernandaRemedio,FranciscoNolasco,FernandoAnti-phospholipase A2 receptoridiopathic membranous nephropathynephrotic syndromepodocyteopen accesshttp://purl.org/coar/access_right/c_abf2http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000100008URLhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000100008URLHasVersion2015-03-01Circulating anti-phospholipase A2 receptor antibodies (anti-PLA2R) have been described in 70% to 80% of the patients with idiopathic membranous nephropathy (iMN), but not in patients with secondary membranous nephropathy or other glomerular diseases. The goal of this study was to evaluate the sensitivity and specificity of the assay for anti-PLA2R in the diagnosis of iMN. Anti-PLA2R IgG, Elisa and immunofluorescence tests were used to detect circulating anti-PLA2R. These tests were applied in 53 patients who had a kidney biopsy. Of these, 38 had histological diagnosis of membranous nephropathy (MN) and the remaining had other glomerular diseases. The MN was classified as idiopathic in 33 patients after clinical exclusion of secondary causes. Anti-PLA2R were positive in 57.6% of the patients with iMN. All patients with secondary membranous nephropathy or other glomerular diseases did not show circulating anti-PLA2R. The sensitivity was 57.6% (CI 39.2-74.5) and specificity 100% (CI 47.8-100), AUC 0.788; p < 0.0001 for the detection of iMN. 71.4% of the iMN patients that tested negative for anti-PLA2R were in partial or complete remission. The detection of anti-PLA2R in the studied population had a specificity of 100% for the iMN diagnosis. Prior treatments seem to make the test negative and contribute to a lower sensitivitySociedade Portuguesa de NefrologiaPortuguese Journal of Nephrology & Hypertension v.29 n.1 2015text/htmlengjournal articlehttp://purl.org/coar/resource_type/c_6501literature |
| spellingShingle | Anti-phospholipase A2 receptor antibodies in the diagnosis of idiopathic membranous nephropathy Meneses,Guida Anti-phospholipase A2 receptor idiopathic membranous nephropathy nephrotic syndrome podocyte |
| status | SINGLETON |
| subject.fl_str_mv | Anti-phospholipase A2 receptor idiopathic membranous nephropathy nephrotic syndrome podocyte |
| title | Anti-phospholipase A2 receptor antibodies in the diagnosis of idiopathic membranous nephropathy |
| title_full | Anti-phospholipase A2 receptor antibodies in the diagnosis of idiopathic membranous nephropathy |
| title_fullStr | Anti-phospholipase A2 receptor antibodies in the diagnosis of idiopathic membranous nephropathy |
| title_full_unstemmed | Anti-phospholipase A2 receptor antibodies in the diagnosis of idiopathic membranous nephropathy |
| title_short | Anti-phospholipase A2 receptor antibodies in the diagnosis of idiopathic membranous nephropathy |
| title_sort | Anti-phospholipase A2 receptor antibodies in the diagnosis of idiopathic membranous nephropathy |
| topic | Anti-phospholipase A2 receptor idiopathic membranous nephropathy nephrotic syndrome podocyte |
| topic_facet | Anti-phospholipase A2 receptor idiopathic membranous nephropathy nephrotic syndrome podocyte |
| url | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000100008 |
| visible | 1 |