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Primary malignant peritoneal mesothelioma associated with renal cell carcinoma - A concise review based on a clinical case

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Resumo:Malignant peritoneal mesothelioma mesothelioma is associated with a long a exposure to asbestos and usually has a poor prognosis. Short survival is due to late diagnosis, as patients are frequently pauci-symptomatic until advanced stage. Since the tumor is usually confined to the peritoneal cavity, extensive peritonectomy and hypertermic intraoperative intraperitoneal chemotherapy are associated with increased survival in selected patients. The synchronous occurrence of primary malignant peritoneal mesothelioma and renal cell carcinoma has not yet been described. A concise literature review of symptomatology of peritoneal mesothelioma, paraneoplastic syndromes (dysfunctional biochemical hepatopathy, wasting syndrome); role of asbestos fibers in pathogenesis; mechanisms of intraperitoneal dissemination; CT scan evaluation; relevance of immunohistochemistry for histopathologic diagnosis; staging of tumors; multidisciplinary approach for treatment of these malignancies is performed.
Autores principais:Murinello,António
Outros Autores:Carvalho,Ana; Figueiredo,A. Manuel; Damásio,Helena; Murillo,M. Jesus; Nunes,Garção; Baptista,Marta; Martins,A. Raquel
Assunto:Malignant peritoneal mesothelioma Asbestos Paraneoplastic hepatopathy Renal cell cancer Cytoreductive surgery Hyperthermic intraoperative intraperitoneal chemotherapy
Ano:2010
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Fundação para a Ciência e Tecnologia
Idioma:inglês
Origem:SciELO Portugal
Descrição
Resumo:Malignant peritoneal mesothelioma mesothelioma is associated with a long a exposure to asbestos and usually has a poor prognosis. Short survival is due to late diagnosis, as patients are frequently pauci-symptomatic until advanced stage. Since the tumor is usually confined to the peritoneal cavity, extensive peritonectomy and hypertermic intraoperative intraperitoneal chemotherapy are associated with increased survival in selected patients. The synchronous occurrence of primary malignant peritoneal mesothelioma and renal cell carcinoma has not yet been described. A concise literature review of symptomatology of peritoneal mesothelioma, paraneoplastic syndromes (dysfunctional biochemical hepatopathy, wasting syndrome); role of asbestos fibers in pathogenesis; mechanisms of intraperitoneal dissemination; CT scan evaluation; relevance of immunohistochemistry for histopathologic diagnosis; staging of tumors; multidisciplinary approach for treatment of these malignancies is performed.