Publicação
Treat-to-Target in Inflammatory Bowel Disease: An Updated Survey of Treatment Strategies among Portuguese Gastroenterologists
| Resumo: | Abstract Background: In 2018, the authors surveyed the clinical practices among Portuguese gastroenterologists (PGEs) regarding treatment targets in Crohn’s disease (CD) and ulcerative colitis (UC). Since then, new evidence has emerged supporting additional targets, such as transmural remission and histological remission. This study provides an updated assessment of treatment practices among PGE with special emphasis on these new targets. Methods: Using the Portuguese Inflammatory bowel disease Study Group (GEDII) physician database, we invited PGE to participate in an anonymous online survey. Results: Fifty-six physicians agreed to participate in the study. Deep remission, steroid-free clinical remission, endoscopic remission, and biomarker remission were ranked among the most important treatment targets in CD (89%, 80%, 89%, and 84%, respectively) and UC (82%, 84%, 79%, and 84%, respectively). In CD, transmural remission was considered a target by 70% of participants, with 48% agreeing to intensify treatment to achieve it. In UC, histological remission was aimed by only 45% of PGE with most (88%) being unwilling to intensify treatment to achieve this goal. Physicians were more likely to seek endoscopic remission in CD and UC in younger and healthier patients, compared to older patients with comorbidities. Conclusion: PGEs are increasingly pursuing tougher treatment targets such as transmural remission in CD and, to a lesser extent, histological remission in UC. Physicians are more willing to escalate treatment to achieve endoscopic remissioninyounger patients. |
|---|---|
| Autores principais: | Sousa,Diogo Couto |
| Outros Autores: | Fernandes,Samuel Raimundo; Bernardo,Sónia; Correia,Luís; Cortez-Pinto,Helena; Magro,Fernando |
| Assunto: | Inflammatory bowel disease Transmural remission Histological remission |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Fundação para a Ciência e Tecnologia |
| Idioma: | inglês |
| Origem: | SciELO Portugal |
| _version_ | 1868442041351929856 |
|---|---|
| author | Sousa,Diogo Couto |
| author2 | Fernandes,Samuel Raimundo Bernardo,Sónia Correia,Luís Cortez-Pinto,Helena Magro,Fernando |
| author2_role | author author author author author |
| author_facet | Sousa,Diogo Couto Fernandes,Samuel Raimundo Bernardo,Sónia Correia,Luís Cortez-Pinto,Helena Magro,Fernando |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Sousa,Diogo Couto\"},{\"Person.name\":\"Fernandes,Samuel Raimundo\"},{\"Person.name\":\"Bernardo,Sónia\"},{\"Person.name\":\"Correia,Luís\"},{\"Person.name\":\"Cortez-Pinto,Helena\"},{\"Person.name\":\"Magro,Fernando\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Sousa,Diogo Couto Fernandes,Samuel Raimundo Bernardo,Sónia Correia,Luís Cortez-Pinto,Helena Magro,Fernando |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Inflammatory bowel disease Transmural remission Histological remission |
| datacite.titles.title.fl_str_mv | Treat-to-Target in Inflammatory Bowel Disease: An Updated Survey of Treatment Strategies among Portuguese Gastroenterologists |
| dc.creator.none.fl_str_mv | Sousa,Diogo Couto Fernandes,Samuel Raimundo Bernardo,Sónia Correia,Luís Cortez-Pinto,Helena Magro,Fernando |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452025000400047 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Sociedade Portuguesa de Gastrenterologia |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | GE-Portuguese Journal of Gastroenterology v.32 n.4 2025 |
| dc.subject.none.fl_str_mv | Inflammatory bowel disease Transmural remission Histological remission |
| dc.title.fl_str_mv | Treat-to-Target in Inflammatory Bowel Disease: An Updated Survey of Treatment Strategies among Portuguese Gastroenterologists |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Abstract Background: In 2018, the authors surveyed the clinical practices among Portuguese gastroenterologists (PGEs) regarding treatment targets in Crohn’s disease (CD) and ulcerative colitis (UC). Since then, new evidence has emerged supporting additional targets, such as transmural remission and histological remission. This study provides an updated assessment of treatment practices among PGE with special emphasis on these new targets. Methods: Using the Portuguese Inflammatory bowel disease Study Group (GEDII) physician database, we invited PGE to participate in an anonymous online survey. Results: Fifty-six physicians agreed to participate in the study. Deep remission, steroid-free clinical remission, endoscopic remission, and biomarker remission were ranked among the most important treatment targets in CD (89%, 80%, 89%, and 84%, respectively) and UC (82%, 84%, 79%, and 84%, respectively). In CD, transmural remission was considered a target by 70% of participants, with 48% agreeing to intensify treatment to achieve it. In UC, histological remission was aimed by only 45% of PGE with most (88%) being unwilling to intensify treatment to achieve this goal. Physicians were more likely to seek endoscopic remission in CD and UC in younger and healthier patients, compared to older patients with comorbidities. Conclusion: PGEs are increasingly pursuing tougher treatment targets such as transmural remission in CD and, to a lesser extent, histological remission in UC. Physicians are more willing to escalate treatment to achieve endoscopic remissioninyounger patients. |
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| format | article |
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| identifier.url.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452025000400047 |
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| institution | Fundação para a Ciência e Tecnologia |
| instname_str | Fundação para a Ciência e Tecnologia |
| language | eng |
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| network_name_str | SciELO Portugal |
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| organization_str_mv | urn:organizationAcronym:scielo |
| person_str_mv | Sousa,Diogo Couto Fernandes,Samuel Raimundo Bernardo,Sónia Correia,Luís Cortez-Pinto,Helena Magro,Fernando |
| publishDate | 2025 |
| publisher.none.fl_str_mv | Sociedade Portuguesa de Gastrenterologia |
| reponame_str | SciELO Portugal |
| repository_id_str | urn:repositoryAcronym:scielopt |
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| spelling | Treat-to-Target in Inflammatory Bowel Disease: An Updated Survey of Treatment Strategies among Portuguese GastroenterologistsSousa,Diogo CoutoFernandes,Samuel RaimundoBernardo,SóniaCorreia,LuísCortez-Pinto,HelenaMagro,FernandoInflammatory bowel diseaseTransmural remissionHistological remissionopen accesshttp://purl.org/coar/access_right/c_abf2http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452025000400047URLhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452025000400047URLHasVersion2025-08-01Abstract Background: In 2018, the authors surveyed the clinical practices among Portuguese gastroenterologists (PGEs) regarding treatment targets in Crohn’s disease (CD) and ulcerative colitis (UC). Since then, new evidence has emerged supporting additional targets, such as transmural remission and histological remission. This study provides an updated assessment of treatment practices among PGE with special emphasis on these new targets. Methods: Using the Portuguese Inflammatory bowel disease Study Group (GEDII) physician database, we invited PGE to participate in an anonymous online survey. Results: Fifty-six physicians agreed to participate in the study. Deep remission, steroid-free clinical remission, endoscopic remission, and biomarker remission were ranked among the most important treatment targets in CD (89%, 80%, 89%, and 84%, respectively) and UC (82%, 84%, 79%, and 84%, respectively). In CD, transmural remission was considered a target by 70% of participants, with 48% agreeing to intensify treatment to achieve it. In UC, histological remission was aimed by only 45% of PGE with most (88%) being unwilling to intensify treatment to achieve this goal. Physicians were more likely to seek endoscopic remission in CD and UC in younger and healthier patients, compared to older patients with comorbidities. Conclusion: PGEs are increasingly pursuing tougher treatment targets such as transmural remission in CD and, to a lesser extent, histological remission in UC. Physicians are more willing to escalate treatment to achieve endoscopic remissioninyounger patients.Sociedade Portuguesa de GastrenterologiaGE-Portuguese Journal of Gastroenterology v.32 n.4 2025text/htmlengjournal articlehttp://purl.org/coar/resource_type/c_6501literature |
| spellingShingle | Treat-to-Target in Inflammatory Bowel Disease: An Updated Survey of Treatment Strategies among Portuguese Gastroenterologists Sousa,Diogo Couto Inflammatory bowel disease Transmural remission Histological remission |
| status | SINGLETON |
| subject.fl_str_mv | Inflammatory bowel disease Transmural remission Histological remission |
| title | Treat-to-Target in Inflammatory Bowel Disease: An Updated Survey of Treatment Strategies among Portuguese Gastroenterologists |
| title_full | Treat-to-Target in Inflammatory Bowel Disease: An Updated Survey of Treatment Strategies among Portuguese Gastroenterologists |
| title_fullStr | Treat-to-Target in Inflammatory Bowel Disease: An Updated Survey of Treatment Strategies among Portuguese Gastroenterologists |
| title_full_unstemmed | Treat-to-Target in Inflammatory Bowel Disease: An Updated Survey of Treatment Strategies among Portuguese Gastroenterologists |
| title_short | Treat-to-Target in Inflammatory Bowel Disease: An Updated Survey of Treatment Strategies among Portuguese Gastroenterologists |
| title_sort | Treat-to-Target in Inflammatory Bowel Disease: An Updated Survey of Treatment Strategies among Portuguese Gastroenterologists |
| topic | Inflammatory bowel disease Transmural remission Histological remission |
| topic_facet | Inflammatory bowel disease Transmural remission Histological remission |
| url | http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452025000400047 |
| visible | 1 |