Publicação
Posterior reversible encephalopathy syndrome as a kidney transplant immunosuppressive therapy side effect
| Resumo: | Successful kidney transplant improves the quality of life and reduces the mortality risk for most patients when compared to maintenance dialysis. We present the case of a 61-year-old woman with chronic kidney disease stage 5-d who received a deceased donor renal transplant. At 21 months after transplantation she developed early post-transplant diabetes and was diagnosed with Pneumocystis jirovecii pneumonia. Her basal creatinine level was 1.1 mg/dL. The patient was admitted with a 7-day history of fever, productive cough, anorexia and right hand altered mobility and sensibility. She was diagnosed with Aspergillus fumigatus pneumonia and the encephalocranial magnetic resonance was suggestive of posterior reversible encephalopathy syndrome, possibly related to high tacrolimus serum levels. Approximately a month later, a renal ultrasound scan and further abdomen computed tomography scan (CT) suggested a tumour and the patient was submitted to right nephrectomy. After discharge, she has been regularly evaluated, maintaining a stable serum creatinine of 2.3 mg/dL, no symptoms associated. This clinical case highlights the myriad of potential complications that transplant recipients are vulnerable to when receiving immunosuppressive therapy. |
|---|---|
| Autores principais: | Melo,Maria João |
| Outros Autores: | Nascimento,Célia; Guerra,José; Gonçalves,João; Santana,Alice |
| Assunto: | Immunosuppressants kidney transplant posterior reversible encephalopathy syndrome |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Fundação para a Ciência e Tecnologia |
| Idioma: | inglês |
| Origem: | SciELO Portugal |
| _version_ | 1868441695357501440 |
|---|---|
| author | Melo,Maria João |
| author2 | Nascimento,Célia Guerra,José Gonçalves,João Santana,Alice |
| author2_role | author author author author |
| author_facet | Melo,Maria João Nascimento,Célia Guerra,José Gonçalves,João Santana,Alice |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Melo,Maria João\"},{\"Person.name\":\"Nascimento,Célia\"},{\"Person.name\":\"Guerra,José\"},{\"Person.name\":\"Gonçalves,João\"},{\"Person.name\":\"Santana,Alice\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Melo,Maria João Nascimento,Célia Guerra,José Gonçalves,João Santana,Alice |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Immunosuppressants kidney transplant posterior reversible encephalopathy syndrome |
| datacite.titles.title.fl_str_mv | Posterior reversible encephalopathy syndrome as a kidney transplant immunosuppressive therapy side effect |
| dc.creator.none.fl_str_mv | Melo,Maria João Nascimento,Célia Guerra,José Gonçalves,João Santana,Alice |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000200008 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Sociedade Portuguesa de Nefrologia |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | Portuguese Journal of Nephrology & Hypertension v.29 n.2 2015 |
| dc.subject.none.fl_str_mv | Immunosuppressants kidney transplant posterior reversible encephalopathy syndrome |
| dc.title.fl_str_mv | Posterior reversible encephalopathy syndrome as a kidney transplant immunosuppressive therapy side effect |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Successful kidney transplant improves the quality of life and reduces the mortality risk for most patients when compared to maintenance dialysis. We present the case of a 61-year-old woman with chronic kidney disease stage 5-d who received a deceased donor renal transplant. At 21 months after transplantation she developed early post-transplant diabetes and was diagnosed with Pneumocystis jirovecii pneumonia. Her basal creatinine level was 1.1 mg/dL. The patient was admitted with a 7-day history of fever, productive cough, anorexia and right hand altered mobility and sensibility. She was diagnosed with Aspergillus fumigatus pneumonia and the encephalocranial magnetic resonance was suggestive of posterior reversible encephalopathy syndrome, possibly related to high tacrolimus serum levels. Approximately a month later, a renal ultrasound scan and further abdomen computed tomography scan (CT) suggested a tumour and the patient was submitted to right nephrectomy. After discharge, she has been regularly evaluated, maintaining a stable serum creatinine of 2.3 mg/dL, no symptoms associated. This clinical case highlights the myriad of potential complications that transplant recipients are vulnerable to when receiving immunosuppressive therapy. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| id | scielopt_c1951e9c0bf0184bef35a149569da083 |
| identifier.url.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000200008 |
| instacron_str | SciELO |
| institution | Fundação para a Ciência e Tecnologia |
| instname_str | Fundação para a Ciência e Tecnologia |
| language | eng |
| network_acronym_str | scielopt |
| network_name_str | SciELO Portugal |
| oai_identifier_str | oai:scielo:S0872-01692015000200008 |
| organization_str_mv | urn:organizationAcronym:scielo |
| person_str_mv | Melo,Maria João Nascimento,Célia Guerra,José Gonçalves,João Santana,Alice |
| publishDate | 2015 |
| publisher.none.fl_str_mv | Sociedade Portuguesa de Nefrologia |
| reponame_str | SciELO Portugal |
| repository_id_str | urn:repositoryAcronym:scielopt |
| service_str_mv | urn:repositoryAcronym:scielopt |
| spelling | Posterior reversible encephalopathy syndrome as a kidney transplant immunosuppressive therapy side effectMelo,Maria JoãoNascimento,CéliaGuerra,JoséGonçalves,JoãoSantana,AliceImmunosuppressantskidney transplantposterior reversible encephalopathy syndromeopen accesshttp://purl.org/coar/access_right/c_abf2http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000200008URLhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000200008URLHasVersion2015-06-01Successful kidney transplant improves the quality of life and reduces the mortality risk for most patients when compared to maintenance dialysis. We present the case of a 61-year-old woman with chronic kidney disease stage 5-d who received a deceased donor renal transplant. At 21 months after transplantation she developed early post-transplant diabetes and was diagnosed with Pneumocystis jirovecii pneumonia. Her basal creatinine level was 1.1 mg/dL. The patient was admitted with a 7-day history of fever, productive cough, anorexia and right hand altered mobility and sensibility. She was diagnosed with Aspergillus fumigatus pneumonia and the encephalocranial magnetic resonance was suggestive of posterior reversible encephalopathy syndrome, possibly related to high tacrolimus serum levels. Approximately a month later, a renal ultrasound scan and further abdomen computed tomography scan (CT) suggested a tumour and the patient was submitted to right nephrectomy. After discharge, she has been regularly evaluated, maintaining a stable serum creatinine of 2.3 mg/dL, no symptoms associated. This clinical case highlights the myriad of potential complications that transplant recipients are vulnerable to when receiving immunosuppressive therapy.Sociedade Portuguesa de NefrologiaPortuguese Journal of Nephrology & Hypertension v.29 n.2 2015text/htmlengjournal articlehttp://purl.org/coar/resource_type/c_6501literature |
| spellingShingle | Posterior reversible encephalopathy syndrome as a kidney transplant immunosuppressive therapy side effect Melo,Maria João Immunosuppressants kidney transplant posterior reversible encephalopathy syndrome |
| status | SINGLETON |
| subject.fl_str_mv | Immunosuppressants kidney transplant posterior reversible encephalopathy syndrome |
| title | Posterior reversible encephalopathy syndrome as a kidney transplant immunosuppressive therapy side effect |
| title_full | Posterior reversible encephalopathy syndrome as a kidney transplant immunosuppressive therapy side effect |
| title_fullStr | Posterior reversible encephalopathy syndrome as a kidney transplant immunosuppressive therapy side effect |
| title_full_unstemmed | Posterior reversible encephalopathy syndrome as a kidney transplant immunosuppressive therapy side effect |
| title_short | Posterior reversible encephalopathy syndrome as a kidney transplant immunosuppressive therapy side effect |
| title_sort | Posterior reversible encephalopathy syndrome as a kidney transplant immunosuppressive therapy side effect |
| topic | Immunosuppressants kidney transplant posterior reversible encephalopathy syndrome |
| topic_facet | Immunosuppressants kidney transplant posterior reversible encephalopathy syndrome |
| url | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692015000200008 |
| visible | 1 |