Publicação
Proton Pump Inhibitors: Are They a Real Threat to the Patient?
| Resumo: | Background: Proton pump inhibitors are among the most frequently prescribed drugs in the world and are generally considered safe. However, there is growing concern regarding their safety. Summary: A nonsystematic review of the current literature was performed regarding proton pump inhibitors and their adverse effects. Proton pump inhibitors seem to be associated with fundic gland polyp development (without clinical relevance) and Clostridium difficile infection. Also, in cirrhotic patients, their prescription should be carefully reviewed. Regarding their association with other enteric infections, micronutrient deficiency, dementia, and chronic kidney disease, current evidence is still of low quality, and further studies are needed. Key Messages: Considering the current evidence, most patients with a clear clinical indication for proton pump inhibitor treatment should probably benefit from the maintenance of their treatment without significant adverse effects. However, higher-quality studies are needed to confirm or dismiss most of the proposed adverse effects. |
|---|---|
| Autores principais: | Xavier,Sofia |
| Outros Autores: | Magalhães,Joana; Cotter,José |
| Assunto: | Proton pump inhibitors Safety Adverse effects |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Fundação para a Ciência e Tecnologia |
| Idioma: | inglês |
| Origem: | SciELO Portugal |
| _version_ | 1868441987821076480 |
|---|---|
| author | Xavier,Sofia |
| author2 | Magalhães,Joana Cotter,José |
| author2_role | author author |
| author_facet | Xavier,Sofia Magalhães,Joana Cotter,José |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Xavier,Sofia\"},{\"Person.name\":\"Magalhães,Joana\"},{\"Person.name\":\"Cotter,José\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Xavier,Sofia Magalhães,Joana Cotter,José |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Proton pump inhibitors Safety Adverse effects |
| datacite.titles.title.fl_str_mv | Proton Pump Inhibitors: Are They a Real Threat to the Patient? |
| dc.creator.none.fl_str_mv | Xavier,Sofia Magalhães,Joana Cotter,José |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452018000500006 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Sociedade Portuguesa de Gastrenterologia |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | GE-Portuguese Journal of Gastroenterology v.25 n.5 2018 |
| dc.subject.none.fl_str_mv | Proton pump inhibitors Safety Adverse effects |
| dc.title.fl_str_mv | Proton Pump Inhibitors: Are They a Real Threat to the Patient? |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Background: Proton pump inhibitors are among the most frequently prescribed drugs in the world and are generally considered safe. However, there is growing concern regarding their safety. Summary: A nonsystematic review of the current literature was performed regarding proton pump inhibitors and their adverse effects. Proton pump inhibitors seem to be associated with fundic gland polyp development (without clinical relevance) and Clostridium difficile infection. Also, in cirrhotic patients, their prescription should be carefully reviewed. Regarding their association with other enteric infections, micronutrient deficiency, dementia, and chronic kidney disease, current evidence is still of low quality, and further studies are needed. Key Messages: Considering the current evidence, most patients with a clear clinical indication for proton pump inhibitor treatment should probably benefit from the maintenance of their treatment without significant adverse effects. However, higher-quality studies are needed to confirm or dismiss most of the proposed adverse effects. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| id | scielopt_e019a4686c60d7bbadae927d02de2eb2 |
| identifier.url.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452018000500006 |
| instacron_str | SciELO |
| institution | Fundação para a Ciência e Tecnologia |
| instname_str | Fundação para a Ciência e Tecnologia |
| language | eng |
| network_acronym_str | scielopt |
| network_name_str | SciELO Portugal |
| oai_identifier_str | oai:scielo:S2341-45452018000500006 |
| organization_str_mv | urn:organizationAcronym:scielo |
| person_str_mv | Xavier,Sofia Magalhães,Joana Cotter,José |
| publishDate | 2018 |
| publisher.none.fl_str_mv | Sociedade Portuguesa de Gastrenterologia |
| reponame_str | SciELO Portugal |
| repository_id_str | urn:repositoryAcronym:scielopt |
| service_str_mv | urn:repositoryAcronym:scielopt |
| spelling | Proton Pump Inhibitors: Are They a Real Threat to the Patient?Xavier,SofiaMagalhães,JoanaCotter,JoséProton pump inhibitorsSafetyAdverse effectsopen accesshttp://purl.org/coar/access_right/c_abf2http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452018000500006URLhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452018000500006URLHasVersion2018-10-01Background: Proton pump inhibitors are among the most frequently prescribed drugs in the world and are generally considered safe. However, there is growing concern regarding their safety. Summary: A nonsystematic review of the current literature was performed regarding proton pump inhibitors and their adverse effects. Proton pump inhibitors seem to be associated with fundic gland polyp development (without clinical relevance) and Clostridium difficile infection. Also, in cirrhotic patients, their prescription should be carefully reviewed. Regarding their association with other enteric infections, micronutrient deficiency, dementia, and chronic kidney disease, current evidence is still of low quality, and further studies are needed. Key Messages: Considering the current evidence, most patients with a clear clinical indication for proton pump inhibitor treatment should probably benefit from the maintenance of their treatment without significant adverse effects. However, higher-quality studies are needed to confirm or dismiss most of the proposed adverse effects.Sociedade Portuguesa de GastrenterologiaGE-Portuguese Journal of Gastroenterology v.25 n.5 2018text/htmlengjournal articlehttp://purl.org/coar/resource_type/c_6501literature |
| spellingShingle | Proton Pump Inhibitors: Are They a Real Threat to the Patient? Xavier,Sofia Proton pump inhibitors Safety Adverse effects |
| status | SINGLETON |
| subject.fl_str_mv | Proton pump inhibitors Safety Adverse effects |
| title | Proton Pump Inhibitors: Are They a Real Threat to the Patient? |
| title_full | Proton Pump Inhibitors: Are They a Real Threat to the Patient? |
| title_fullStr | Proton Pump Inhibitors: Are They a Real Threat to the Patient? |
| title_full_unstemmed | Proton Pump Inhibitors: Are They a Real Threat to the Patient? |
| title_short | Proton Pump Inhibitors: Are They a Real Threat to the Patient? |
| title_sort | Proton Pump Inhibitors: Are They a Real Threat to the Patient? |
| topic | Proton pump inhibitors Safety Adverse effects |
| topic_facet | Proton pump inhibitors Safety Adverse effects |
| url | http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452018000500006 |
| visible | 1 |