Publicação
Evaluation of Small-Bowel Patency in Crohns Disease: Prospective Study with a Patency Capsule and Computed Tomography
| Resumo: | Background and Purpose: Patency capsule (PC) examination is usually performed - previously to capsule endoscopy - to evaluate small-bowel patency in patients with established Crohns disease (CD). The reported PC retention rate is significantly higher than expected. Our aims were to assess small-bowel patency, to determine the precise location of the retained PC in patients with CD, and to determine the false positive rate of evaluation with a radiofrequency identification tag (RFIT) scanner. Methods: This is a prospective single-center study including CD patients with clinical indication for small-bowel capsule endoscopy. PillCam® PC examination was performed on all patients to assess smallbowel patency. On all patients with a positive identification of the PC using an RFIT scanner, 30 h after ingestion, an abdominal CT was performed in order to identify its precise location. Results: Fifty-four patients were included. The PC retention rate, according to evaluation with the RFIT scanner, was 20% (in 11 patients) 30 h after ingestion. These patients were then submitted to abdominal CT, which revealed that there was small-bowel retention in 5 cases (9%). Higher CRP levels, penetrating disease, and a history of abdominal surgery were associated with an increased risk of PC retention (p = 0.007, p = 0.011, and p = 0.033, respectively). On multivariate analysis, there was an independent association between small-bowel PC retention and CRP levels > 5 mg/dL (OR = 15.5; p = 0.03). Discussion: The small-bowel PC retention rate (9%) was considerably lower than those found in previous reports. Our results show that, with this protocol, the false-positive cases of RFIT scans or plain abdominal Xrays may be avoided. This may contribute to more extensive application of capsule endoscopy without the risk of smallbowel retention. |
|---|---|
| Autores principais: | Silva,Marco |
| Outros Autores: | Cardoso,Hélder; Cunha,Rui; Peixoto,Armando; Gaspar,Rui; Gomes,Sara; Santos,Ana Luísa; Lopes,Susana; Macedo,Guilherme |
| Assunto: | Inflammatory bowel disease Diagnosis and imaging Small-bowel endoscopy Capsule endoscopy Gastrointestinal radiology |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Fundação para a Ciência e Tecnologia |
| Idioma: | inglês |
| Origem: | SciELO Portugal |
| _version_ | 1868441987995140096 |
|---|---|
| author | Silva,Marco |
| author2 | Cardoso,Hélder Cunha,Rui Peixoto,Armando Gaspar,Rui Gomes,Sara Santos,Ana Luísa Lopes,Susana Macedo,Guilherme |
| author2_role | author author author author author author author author |
| author_facet | Silva,Marco Cardoso,Hélder Cunha,Rui Peixoto,Armando Gaspar,Rui Gomes,Sara Santos,Ana Luísa Lopes,Susana Macedo,Guilherme |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Silva,Marco\"},{\"Person.name\":\"Cardoso,Hélder\"},{\"Person.name\":\"Cunha,Rui\"},{\"Person.name\":\"Peixoto,Armando\"},{\"Person.name\":\"Gaspar,Rui\"},{\"Person.name\":\"Gomes,Sara\"},{\"Person.name\":\"Santos,Ana Luísa\"},{\"Person.name\":\"Lopes,Susana\"},{\"Person.name\":\"Macedo,Guilherme\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Silva,Marco Cardoso,Hélder Cunha,Rui Peixoto,Armando Gaspar,Rui Gomes,Sara Santos,Ana Luísa Lopes,Susana Macedo,Guilherme |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Inflammatory bowel disease Diagnosis and imaging Small-bowel endoscopy Capsule endoscopy Gastrointestinal radiology |
| datacite.titles.title.fl_str_mv | Evaluation of Small-Bowel Patency in Crohns Disease: Prospective Study with a Patency Capsule and Computed Tomography |
| dc.creator.none.fl_str_mv | Silva,Marco Cardoso,Hélder Cunha,Rui Peixoto,Armando Gaspar,Rui Gomes,Sara Santos,Ana Luísa Lopes,Susana Macedo,Guilherme |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452019000600003 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Sociedade Portuguesa de Gastrenterologia |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | GE-Portuguese Journal of Gastroenterology v.26 n.6 2019 |
| dc.subject.none.fl_str_mv | Inflammatory bowel disease Diagnosis and imaging Small-bowel endoscopy Capsule endoscopy Gastrointestinal radiology |
| dc.title.fl_str_mv | Evaluation of Small-Bowel Patency in Crohns Disease: Prospective Study with a Patency Capsule and Computed Tomography |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Background and Purpose: Patency capsule (PC) examination is usually performed - previously to capsule endoscopy - to evaluate small-bowel patency in patients with established Crohns disease (CD). The reported PC retention rate is significantly higher than expected. Our aims were to assess small-bowel patency, to determine the precise location of the retained PC in patients with CD, and to determine the false positive rate of evaluation with a radiofrequency identification tag (RFIT) scanner. Methods: This is a prospective single-center study including CD patients with clinical indication for small-bowel capsule endoscopy. PillCam® PC examination was performed on all patients to assess smallbowel patency. On all patients with a positive identification of the PC using an RFIT scanner, 30 h after ingestion, an abdominal CT was performed in order to identify its precise location. Results: Fifty-four patients were included. The PC retention rate, according to evaluation with the RFIT scanner, was 20% (in 11 patients) 30 h after ingestion. These patients were then submitted to abdominal CT, which revealed that there was small-bowel retention in 5 cases (9%). Higher CRP levels, penetrating disease, and a history of abdominal surgery were associated with an increased risk of PC retention (p = 0.007, p = 0.011, and p = 0.033, respectively). On multivariate analysis, there was an independent association between small-bowel PC retention and CRP levels > 5 mg/dL (OR = 15.5; p = 0.03). Discussion: The small-bowel PC retention rate (9%) was considerably lower than those found in previous reports. Our results show that, with this protocol, the false-positive cases of RFIT scans or plain abdominal Xrays may be avoided. This may contribute to more extensive application of capsule endoscopy without the risk of smallbowel retention. |
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| eu_rights_str_mv | openAccess |
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| identifier.url.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452019000600003 |
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| institution | Fundação para a Ciência e Tecnologia |
| instname_str | Fundação para a Ciência e Tecnologia |
| language | eng |
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| organization_str_mv | urn:organizationAcronym:scielo |
| person_str_mv | Silva,Marco Cardoso,Hélder Cunha,Rui Peixoto,Armando Gaspar,Rui Gomes,Sara Santos,Ana Luísa Lopes,Susana Macedo,Guilherme |
| publishDate | 2019 |
| publisher.none.fl_str_mv | Sociedade Portuguesa de Gastrenterologia |
| reponame_str | SciELO Portugal |
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| spelling | Evaluation of Small-Bowel Patency in Crohns Disease: Prospective Study with a Patency Capsule and Computed TomographySilva,MarcoCardoso,HélderCunha,RuiPeixoto,ArmandoGaspar,RuiGomes,SaraSantos,Ana LuísaLopes,SusanaMacedo,GuilhermeInflammatory bowel diseaseDiagnosis and imagingSmall-bowel endoscopyCapsule endoscopyGastrointestinal radiologyopen accesshttp://purl.org/coar/access_right/c_abf2http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452019000600003URLhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452019000600003URLHasVersion2019-12-01Background and Purpose: Patency capsule (PC) examination is usually performed - previously to capsule endoscopy - to evaluate small-bowel patency in patients with established Crohns disease (CD). The reported PC retention rate is significantly higher than expected. Our aims were to assess small-bowel patency, to determine the precise location of the retained PC in patients with CD, and to determine the false positive rate of evaluation with a radiofrequency identification tag (RFIT) scanner. Methods: This is a prospective single-center study including CD patients with clinical indication for small-bowel capsule endoscopy. PillCam® PC examination was performed on all patients to assess smallbowel patency. On all patients with a positive identification of the PC using an RFIT scanner, 30 h after ingestion, an abdominal CT was performed in order to identify its precise location. Results: Fifty-four patients were included. The PC retention rate, according to evaluation with the RFIT scanner, was 20% (in 11 patients) 30 h after ingestion. These patients were then submitted to abdominal CT, which revealed that there was small-bowel retention in 5 cases (9%). Higher CRP levels, penetrating disease, and a history of abdominal surgery were associated with an increased risk of PC retention (p = 0.007, p = 0.011, and p = 0.033, respectively). On multivariate analysis, there was an independent association between small-bowel PC retention and CRP levels > 5 mg/dL (OR = 15.5; p = 0.03). Discussion: The small-bowel PC retention rate (9%) was considerably lower than those found in previous reports. Our results show that, with this protocol, the false-positive cases of RFIT scans or plain abdominal Xrays may be avoided. This may contribute to more extensive application of capsule endoscopy without the risk of smallbowel retention.Sociedade Portuguesa de GastrenterologiaGE-Portuguese Journal of Gastroenterology v.26 n.6 2019text/htmlengjournal articlehttp://purl.org/coar/resource_type/c_6501literature |
| spellingShingle | Evaluation of Small-Bowel Patency in Crohns Disease: Prospective Study with a Patency Capsule and Computed Tomography Silva,Marco Inflammatory bowel disease Diagnosis and imaging Small-bowel endoscopy Capsule endoscopy Gastrointestinal radiology |
| status | SINGLETON |
| subject.fl_str_mv | Inflammatory bowel disease Diagnosis and imaging Small-bowel endoscopy Capsule endoscopy Gastrointestinal radiology |
| title | Evaluation of Small-Bowel Patency in Crohns Disease: Prospective Study with a Patency Capsule and Computed Tomography |
| title_full | Evaluation of Small-Bowel Patency in Crohns Disease: Prospective Study with a Patency Capsule and Computed Tomography |
| title_fullStr | Evaluation of Small-Bowel Patency in Crohns Disease: Prospective Study with a Patency Capsule and Computed Tomography |
| title_full_unstemmed | Evaluation of Small-Bowel Patency in Crohns Disease: Prospective Study with a Patency Capsule and Computed Tomography |
| title_short | Evaluation of Small-Bowel Patency in Crohns Disease: Prospective Study with a Patency Capsule and Computed Tomography |
| title_sort | Evaluation of Small-Bowel Patency in Crohns Disease: Prospective Study with a Patency Capsule and Computed Tomography |
| topic | Inflammatory bowel disease Diagnosis and imaging Small-bowel endoscopy Capsule endoscopy Gastrointestinal radiology |
| topic_facet | Inflammatory bowel disease Diagnosis and imaging Small-bowel endoscopy Capsule endoscopy Gastrointestinal radiology |
| url | http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452019000600003 |
| visible | 1 |